Effects of intracameral cefuroxime on corneal endothelial cell counts and its morphology after cataract surgery

Kourosh Shahraki, Mohammad Naeim Amini Fard, Farkhondeh Shahri, Rama Pourmatin, Tafgeh Mohammadi, Paria Ghasemi Boroumand, Kianoush Shahraki, Kourosh Shahraki, Mohammad Naeim Amini Fard, Farkhondeh Shahri, Rama Pourmatin, Tafgeh Mohammadi, Paria Ghasemi Boroumand, Kianoush Shahraki

Abstract

Background: Endophthalmitis is one of the most important complications after cataract surgery and in case event can cause many symptoms, such as severe decrease in eyesight and/or even the loss of vision. Employing methods to reduce this problem is very important. The aim of this study was to evaluate the effect of intracameral cefuroxime after cataract surgery on corneal endothelial cell counts and its morphology.

Methods: In this study, 32 eyes of 30 patients underwent endothelial cell count and morphology assessment by ConfoScan III device before and 1 month after cataract surgery. All patients undertaken cataract surgery by one surgeon and by one method. Intracameral cefuroxime (1 mg/0.1 ml) was used as prophylaxis of postoperative endophthalmitis at the end of operation.

Results: In this study, the rate of corneal endothelial cell loss 1 month after cataract surgery was 8.4%, and the rate of endothelial cells polymegathism before and after cataract surgery did not differ statistically. During the follow-up period, there were no cases of endophthalmitis or other complications.

Conclusion: With regard to the importance of the intracameral cefuroxime in a reduction in the rate of endophthalmitis after cataract surgery and that harmful effects on the endothelial cells were not seen, this method can be considered as a suitable method for endophthalmitis prophylaxis.

Keywords: cataract; cefuroxime; corneal; endophthalmitis; endothelium; genetic; polymorphism.

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Source: PubMed

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