Effects of Combined Endurance and Resistance Training in Women With Multiple Sclerosis: A Randomized Controlled Study

Luca Correale, Cosme Franklim Buzzachera, Giulia Liberali, Erwan Codrons, Giulia Mallucci, Matteo Vandoni, Cristina Montomoli, Roberto Bergamaschi, Luca Correale, Cosme Franklim Buzzachera, Giulia Liberali, Erwan Codrons, Giulia Mallucci, Matteo Vandoni, Cristina Montomoli, Roberto Bergamaschi

Abstract

Purpose: To test the hypothesis that combined resistance and endurance training would improve muscle strength, fatigue, depression, and quality of life in persons with MS. Methods: Twenty-seven women with MS were randomly assigned to either control (CON, n = 13) or the experimental (EXP, n = 14) group. The participants in the EXP group trained twice a week for 12 weeks, followed by 12 weeks of detraining. Both CON and EXP groups were tested before and after 12 weeks of the intervention period, as well as 12 weeks after training cessation (follow-up), where measures of muscle strength, fatigue, depression, and quality of life were evaluated. Results: There were significant changes in maximal voluntary isometric contraction (MVIC), 1RM leg extension, and 1RM chest press following the intervention period in the EXP group (P < 0.05), but not in the CON group (P > 0.05). These changes persisted after 12 weeks of detraining. Similar findings were found for fatigue, depression, and physical and mental composites of quality of life. Conclusion: These results suggest that combined exercise training, at a minimum, prevents the disease-related deterioration of muscular performance and quality of life and well-being in persons with MS.

Keywords: aerobic training; multiple sclerosis; muscle strength; strength training; training adaptation.

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Copyright © 2021 Correale, Buzzachera, Liberali, Codrons, Mallucci, Vandoni, Montomoli and Bergamaschi.

Figures

Figure 1
Figure 1
Schematic overview of study timeline.
Figure 2
Figure 2
Mean and individual change scores in maximal voluntary isometric contraction (mvic;top left), 1rm leg extension (top right), 1rm chest press (bottom left), and 1rm seated row (bottom right) after combined endurance and resistance training for both control (con; n = 9) and experimental (exp; n = 9) groups. The values are post- minus pretraining (means ±sem). There were no significant differences between groups.
Figure 3
Figure 3
Mean and individual change scores in perceived fatigue (top left), depressive symptoms (top right), and both mental-(bottom left) and physical-(bottom right) composites of health-related quality of life after combined endurance and resistance training for both control (con; n = 9) and experimental (exp; n = 9) groups. The values are post- minus pretraining (means ±sem). There were no significant differences between groups.

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