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- Klinische proef NCT00626405
Bevacizumab and Temozolomide or Bevacizumab and Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Carboplatin in Treating Patients With Stage IV Malignant Melanoma That Cannot Be Removed by Surgery
A Randomized Phase II Trial of Temozolomide (TMZ) and Bevacizumab or ABI-007 (ABX)/Carboplatin (CBDCA) and Bevacizumab in Patients With Unresectable Stage IV Malignant Melanoma
RATIONALE: Drugs used in chemotherapy, such as temozolomide, paclitaxel albumin-stabilized nanoparticle formulation, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether bevacizumab is more effective when given together with temozolomide or paclitaxel albumin-stabilized nanoparticle formulation and carboplatin in killing malignant melanoma cells.
PURPOSE: This randomized phase II trial is studying the side effects of giving temozolomide together with bevacizumab and to see how well it works compared with giving bevacizumab together with paclitaxel albumin-stabilized nanoparticle formulation and carboplatin in treating patients with stage IV malignant melanoma that cannot be removed by surgery.
Studie Overzicht
Toestand
Conditie
Gedetailleerde beschrijving
OBJECTIVES:
Primary
- To assess the anti-tumor activity, in terms of the percentage of patients who are treated with these regimens and who are progression-free at 6 months.
- To assess the safety profile of each treatment regimen.
Secondary
- To estimate the response rate in patients treated with these regimens.
- To estimate the distribution of progression-free survival time and overall survival time of patients treated with these regimens.
Tertiary
- To examine the impact of therapy on angiogenesis and immune homeostasis.
OUTLINE: Patients are stratified according to ECOG performance status (0 vs 1) and location of metastatic disease (M1a [skin or subcutaneous tissue or lymph node only] vs M1b [lung] vs M1c [other visceral sites]) and randomized to 1 of 2 treatment arms.
- Arm I: Patients receive oral temozolomide on days 1-5 and bevacizumab IV over 30-90 minutes on days 1 and 15. (closed to accrual 8/21/09)
- Arm II: Patients receive bevacizumab IV over 30-90 minutes on days 1 and 15, paclitaxel albumin-stabilized nanoparticle formulation IV over 30 minutes on days 1, 8, and 15, and carboplatin IV over 30 minutes on day 1.
In both arms, treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.
Patients undergo blood sample collection periodically for VEGF plasma levels and analysis of changes in immune homeostasis.
Beginning at study entry, patients are followed up every 3 months for 2 years and then every 6 months for up to 3 years.
Studietype
Inschrijving (Werkelijk)
Fase
- Fase 2
Contacten en locaties
Studie Locaties
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Alaska
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Anchorage, Alaska, Verenigde Staten, 99508
- Providence Cancer Center
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Arizona
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Scottsdale, Arizona, Verenigde Staten, 85259-5499
- Mayo Clinic Scottsdale
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Colorado
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Aurora, Colorado, Verenigde Staten, 80012
- Aurora Presbyterian Hospital
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Boulder, Colorado, Verenigde Staten, 80301-9019
- Boulder Community Hospital
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Colorado Springs, Colorado, Verenigde Staten, 80933
- Penrose Cancer Center at Penrose Hospital
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Denver, Colorado, Verenigde Staten, 80210
- Porter Adventist Hospital
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Denver, Colorado, Verenigde Staten, 80220
- Rose Medical Center
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Denver, Colorado, Verenigde Staten, 80218
- Presbyterian - St. Luke's Medical Center
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Denver, Colorado, Verenigde Staten, 80204
- St. Anthony Central Hospital
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Denver, Colorado, Verenigde Staten, 80218
- St. Joseph Hospital
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Denver, Colorado, Verenigde Staten, 80224-2522
- CCOP - Colorado Cancer Research Program
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Englewood, Colorado, Verenigde Staten, 80110
- Swedish Medical Center
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Fort Collins, Colorado, Verenigde Staten, 80528
- Front Range Cancer Specialists
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Grand Junction, Colorado, Verenigde Staten, 81502
- St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
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Greeley, Colorado, Verenigde Staten, 80631
- North Colorado Medical Center
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Lone Tree, Colorado, Verenigde Staten, 80124
- Sky Ridge Medical Center
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Longmont, Colorado, Verenigde Staten, 80501
- Hope Cancer Care Center at Longmont United Hospital
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Loveland, Colorado, Verenigde Staten, 80539
- McKee Medical Center
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Pueblo, Colorado, Verenigde Staten, 81004
- St. Mary - Corwin Regional Medical Center
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Thornton, Colorado, Verenigde Staten, 80229
- North Suburban Medical Center
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Wheat Ridge, Colorado, Verenigde Staten, 80033
- Exempla Lutheran Medical Center
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Florida
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Jacksonville, Florida, Verenigde Staten, 32224
- Mayo Clinic - Jacksonville
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Illinois
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Bloomington, Illinois, Verenigde Staten, 61701
- Illinois CancerCare - Bloomington
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Bloomington, Illinois, Verenigde Staten, 61701
- St. Joseph Medical Center
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Canton, Illinois, Verenigde Staten, 61520
- Illinois CancerCare - Canton
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Canton, Illinois, Verenigde Staten, 61520
- Graham Hospital
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Carthage, Illinois, Verenigde Staten, 62321
- Illinois CancerCare - Carthage
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Eureka, Illinois, Verenigde Staten, 61530
- Illinois CancerCare - Eureka
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Eureka, Illinois, Verenigde Staten, 61530
- Eureka Community Hospital
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Galesburg, Illinois, Verenigde Staten, 61401
- Galesburg Cottage Hospital
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Galesburg, Illinois, Verenigde Staten, 61401
- Galesburg Clinic, PC
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Havana, Illinois, Verenigde Staten, 62644
- Mason District Hospital
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Havana, Illinois, Verenigde Staten, 62644
- Illinois CancerCare - Havana
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Kewanee, Illinois, Verenigde Staten, 61443
- Illinois CancerCare - Kewanee Clinic
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Macomb, Illinois, Verenigde Staten, 61455
- Illinois CancerCare - Macomb
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Macomb, Illinois, Verenigde Staten, 61455
- Mcdonough District Hospital
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Moline, Illinois, Verenigde Staten, 61265
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Moline, Illinois, Verenigde Staten, 61265
- Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
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Monmouth, Illinois, Verenigde Staten, 61462
- Illinois CancerCare - Monmouth
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Monmouth, Illinois, Verenigde Staten, 61462
- OSF Holy Family Medical Center
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Normal, Illinois, Verenigde Staten, 61761
- Bromenn Regional Medical Center
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Normal, Illinois, Verenigde Staten, 61761
- Community Cancer Center
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Normal, Illinois, Verenigde Staten, 61761
- Illinois CancerCare - Community Cancer Center
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Ottawa, Illinois, Verenigde Staten, 61350
- Community Hospital of Ottawa
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Ottawa, Illinois, Verenigde Staten, 61350
- Oncology Hematology Associates of Central Illinois, PC - Ottawa
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Pekin, Illinois, Verenigde Staten, 61554
- Cancer Treatment Center at Pekin Hospital
-
Pekin, Illinois, Verenigde Staten, 61603
- Illinois CancerCare - Pekin
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Peoria, Illinois, Verenigde Staten, 61636
- Methodist Medical Center of Illinois
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Peoria, Illinois, Verenigde Staten, 61614
- Proctor Hospital
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Peoria, Illinois, Verenigde Staten, 61637
- OSF St. Francis Medical Center
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Peoria, Illinois, Verenigde Staten, 61615
- CCOP - Illinois Oncology Research Association
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Peoria, Illinois, Verenigde Staten, 61615
- Oncology Hematology Associates of Central Illinois, PC - Peoria
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Peru, Illinois, Verenigde Staten, 61354
- Illinois CancerCare - Peru
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Peru, Illinois, Verenigde Staten, 61354
- Illinois Valley Community Hospital
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Princeton, Illinois, Verenigde Staten, 61356
- Perry Memorial Hospital
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Princeton, Illinois, Verenigde Staten, 61356
- Illinois CancerCare - Princeton
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Spring Valley, Illinois, Verenigde Staten, 61362
- Illinois CancerCare - Spring Valley
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Spring Valley, Illinois, Verenigde Staten, 61362
- St. Margaret's Hospital
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Indiana
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Beech Grove, Indiana, Verenigde Staten, 46107
- St. Francis Hospital and Health Centers - Beech Grove Campus
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Elkhart, Indiana, Verenigde Staten, 46515
- Elkhart General Hospital
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Kokomo, Indiana, Verenigde Staten, 46904
- Howard Community Hospital
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La Porte, Indiana, Verenigde Staten, 46350
- Center for Cancer Therapy at LaPorte Hospital and Health Services
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Richmond, Indiana, Verenigde Staten, 47374
- Reid Hospital & Health Care Services
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South Bend, Indiana, Verenigde Staten, 46601
- Memorial Hospital of South Bend
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South Bend, Indiana, Verenigde Staten, 46601
- CCOP - Northern Indiana CR Consortium
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South Bend, Indiana, Verenigde Staten, 46617
- Saint Joseph Regional Medical Center
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South Bend, Indiana, Verenigde Staten, 46617
- South Bend Clinic
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Iowa
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Ames, Iowa, Verenigde Staten, 50010
- McFarland Clinic, PC
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Bettendorf, Iowa, Verenigde Staten, 52722
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Cedar Rapids, Iowa, Verenigde Staten, 52403
- Cedar Rapids Oncology Associates
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Cedar Rapids, Iowa, Verenigde Staten, 52403
- Mercy Regional Cancer Center at Mercy Medical Center
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Clive, Iowa, Verenigde Staten, 50325
- Medical Oncology and Hematology Associates - West Des Moines
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Des Moines, Iowa, Verenigde Staten, 50309
- CCOP - Iowa Oncology Research Association
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Des Moines, Iowa, Verenigde Staten, 50309
- John Stoddard Cancer Center at Iowa Methodist Medical Center
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Des Moines, Iowa, Verenigde Staten, 50309
- Medical Oncology and Hematology Associates at John Stoddard Cancer Center
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Des Moines, Iowa, Verenigde Staten, 50314
- Medical Oncology and Hematology Associates at Mercy Cancer Center
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Des Moines, Iowa, Verenigde Staten, 50314
- Mercy Cancer Center at Mercy Medical Center - Des Moines
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Des Moines, Iowa, Verenigde Staten, 50316
- John Stoddard Cancer Center at Iowa Lutheran Hospital
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Des Moines, Iowa, Verenigde Staten, 50307
- Mercy Capitol Hospital
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Mason City, Iowa, Verenigde Staten, 50401
- Mercy Cancer Center at Mercy Medical Center - North Iowa
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Ottumwa, Iowa, Verenigde Staten, 52501
- McCreery Cancer Center at Ottumwa Regional
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Sioux City, Iowa, Verenigde Staten, 51101
- Siouxland Hematology-Oncology Associates, LLP
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Sioux City, Iowa, Verenigde Staten, 51104
- St. Luke's Regional Medical Center
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Sioux City, Iowa, Verenigde Staten, 51104
- Mercy Medical Center - Sioux City
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Kansas
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Anthony, Kansas, Verenigde Staten, 67003
- Hospital District Sixth of Harper County
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Chanute, Kansas, Verenigde Staten, 66720
- Cancer Center of Kansas, PA - Chanute
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Dodge City, Kansas, Verenigde Staten, 67801
- Cancer Center of Kansas, PA - Dodge City
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El Dorado, Kansas, Verenigde Staten, 67042
- Cancer Center of Kansas, PA - El Dorado
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Fort Scott, Kansas, Verenigde Staten, 66701
- Cancer Center of Kansas - Fort Scott
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Independence, Kansas, Verenigde Staten, 67301
- Cancer Center of Kansas-Independence
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Kingman, Kansas, Verenigde Staten, 67068
- Cancer Center of Kansas, PA - Kingman
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Lawrence, Kansas, Verenigde Staten, 66044
- Lawrence Memorial Hospital
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Liberal, Kansas, Verenigde Staten, 67901
- Southwest Medical Center
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Newton, Kansas, Verenigde Staten, 67114
- Cancer Center of Kansas, PA - Newton
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Parsons, Kansas, Verenigde Staten, 67357
- Cancer Center of Kansas, PA - Parsons
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Pratt, Kansas, Verenigde Staten, 67124
- Cancer Center of Kansas, PA - Pratt
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Salina, Kansas, Verenigde Staten, 67042
- Cancer Center of Kansas, PA - Salina
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Wellington, Kansas, Verenigde Staten, 67152
- Cancer Center of Kansas, PA - Wellington
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Wichita, Kansas, Verenigde Staten, 67208
- Cancer Center of Kansas, PA - Medical Arts Tower
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Wichita, Kansas, Verenigde Staten, 67214
- Cancer Center of Kansas, PA - Wichita
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Wichita, Kansas, Verenigde Staten, 67214
- CCOP - Wichita
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Wichita, Kansas, Verenigde Staten, 67214
- Via Christi Cancer Center at Via Christi Regional Medical Center
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Wichita, Kansas, Verenigde Staten, 67208
- Associates in Womens Health, PA - North Review
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Winfield, Kansas, Verenigde Staten, 67156
- Cancer Center of Kansas, PA - Winfield
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Michigan
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Adrian, Michigan, Verenigde Staten, 49221
- Hickman Cancer Center at Bixby Medical Center
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Ann Arbor, Michigan, Verenigde Staten, 48106-0995
- Saint Joseph Mercy Cancer Center
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Ann Arbor, Michigan, Verenigde Staten, 48106
- CCOP - Michigan Cancer Research Consortium
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Battle Creek, Michigan, Verenigde Staten, 49017
- Battle Creek Health System Cancer Care Center
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Big Rapids, Michigan, Verenigde Staten, 49307
- Mecosta County Medical Center
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Dearborn, Michigan, Verenigde Staten, 48123-2500
- Oakwood Cancer Center at Oakwood Hospital and Medical Center
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Escanaba, Michigan, Verenigde Staten, 49431
- Green Bay Oncology, Limited - Escanaba
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Flint, Michigan, Verenigde Staten, 48503
- Hurley Medical Center
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Flint, Michigan, Verenigde Staten, 48503
- Genesys Hurley Cancer Institute
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Grand Rapids, Michigan, Verenigde Staten, 49503
- Butterworth Hospital at Spectrum Health
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Grand Rapids, Michigan, Verenigde Staten, 49503
- CCOP - Grand Rapids
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Grand Rapids, Michigan, Verenigde Staten, 49503
- Lacks Cancer Center at Saint Mary's Health Care
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Grosse Pointe Woods, Michigan, Verenigde Staten, 48236
- Van Elslander Cancer Center at St. John Hospital and Medical Center
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Iron Mountain, Michigan, Verenigde Staten, 49801
- Dickinson County Healthcare System
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Jackson, Michigan, Verenigde Staten, 49201
- Foote Memorial Hospital
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Lambertville, Michigan, Verenigde Staten, 48144
- Haematology-Oncology Associates of Ohio and Michigan, PC
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Lansing, Michigan, Verenigde Staten, 48912-1811
- Sparrow Regional Cancer Center
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Livonia, Michigan, Verenigde Staten, 48154
- St. Mary Mercy Hospital
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Monroe, Michigan, Verenigde Staten, 48162
- Community Cancer Center of Monroe
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Monroe, Michigan, Verenigde Staten, 48162
- Mercy Memorial Hospital - Monroe
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Muskegon, Michigan, Verenigde Staten, 49443
- Mercy General Health Partners
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Pontiac, Michigan, Verenigde Staten, 48341-2985
- St. Joseph Mercy Oakland
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Port Huron, Michigan, Verenigde Staten, 48060
- Mercy Regional Cancer Center at Mercy Hospital
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Saginaw, Michigan, Verenigde Staten, 48601
- Seton Cancer Institute at Saint Mary's - Saginaw
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Saint Joseph, Michigan, Verenigde Staten, 49085
- Lakeland Regional Cancer Care Center - St. Joseph
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Traverse City, Michigan, Verenigde Staten, 49684
- Munson Medical Center
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Warren, Michigan, Verenigde Staten, 48093
- St. John Macomb Hospital
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Wyoming, Michigan, Verenigde Staten, 49519
- Metro Health Hospital
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Minnesota
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Alexandria, Minnesota, Verenigde Staten, 56308
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Bemidji, Minnesota, Verenigde Staten, 56601
- MeritCare Bemidji
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Burnsville, Minnesota, Verenigde Staten, 55337
- Fairview Ridges Hospital
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Coon Rapids, Minnesota, Verenigde Staten, 55433
- Mercy and Unity Cancer Center at Mercy Hospital
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Duluth, Minnesota, Verenigde Staten, 55805
- CCOP - Duluth
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Duluth, Minnesota, Verenigde Staten, 55805-1983
- Duluth Clinic Cancer Center - Duluth
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Duluth, Minnesota, Verenigde Staten, 55805
- Miller - Dwan Medical Center
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Edina, Minnesota, Verenigde Staten, 55435
- Fairview Southdale Hospital
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Fridley, Minnesota, Verenigde Staten, 55432
- Mercy and Unity Cancer Center at Unity Hospital
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Hutchinson, Minnesota, Verenigde Staten, 55350
- Hutchinson Area Health Care
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Maplewood, Minnesota, Verenigde Staten, 55109
- Minnesota Oncology Hematology, PA - Maplewood
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Maplewood, Minnesota, Verenigde Staten, 55109
- HealthEast Cancer Care at St. John's Hospital
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Minneapolis, Minnesota, Verenigde Staten, 55407
- Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
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Minneapolis, Minnesota, Verenigde Staten, 55415
- Hennepin County Medical Center - Minneapolis
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Robbinsdale, Minnesota, Verenigde Staten, 55422-2900
- Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center
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Rochester, Minnesota, Verenigde Staten, 55905
- Mayo Clinic Cancer Center
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Saint Cloud, Minnesota, Verenigde Staten, 56303
- CentraCare Clinic - River Campus
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Saint Cloud, Minnesota, Verenigde Staten, 56303
- Coborn Cancer Center
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Saint Louis Park, Minnesota, Verenigde Staten, 55416
- CCOP - Metro-Minnesota
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Saint Louis Park, Minnesota, Verenigde Staten, 55416
- Park Nicollet Cancer Center
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Saint Paul, Minnesota, Verenigde Staten, 55102
- United Hospital
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Saint Paul, Minnesota, Verenigde Staten, 55101
- Regions Hospital Cancer Care Center
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Shakopee, Minnesota, Verenigde Staten, 55379
- St. Francis Cancer Center at St. Francis Medical Center
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Waconia, Minnesota, Verenigde Staten, 55387
- Ridgeview Medical Center
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Woodbury, Minnesota, Verenigde Staten, 55125
- Minnesota Oncology Hematology, PA - Woodbury
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Missouri
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Saint Louis, Missouri, Verenigde Staten, 63131
- Missouri Baptist Cancer Center
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Saint Louis, Missouri, Verenigde Staten, 63141
- Arch Medical Services, Incorporated at Center for Cancer Care and Research
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Springfield, Missouri, Verenigde Staten, 65802
- CCOP - Cancer Research for the Ozarks
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Springfield, Missouri, Verenigde Staten, 65804
- St. John's Regional Health Center
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Springfield, Missouri, Verenigde Staten, 65807
- Hulston Cancer Center at Cox Medical Center South
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Montana
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Billings, Montana, Verenigde Staten, 59101
- CCOP - Montana Cancer Consortium
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Billings, Montana, Verenigde Staten, 59101
- Hematology-Oncology Centers of the Northern Rockies - Billings
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Billings, Montana, Verenigde Staten, 59101
- Northern Rockies Radiation Oncology Center
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Billings, Montana, Verenigde Staten, 59101
- St. Vincent Healthcare Cancer Care Services
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Billings, Montana, Verenigde Staten, 59107-7000
- Billings Clinic - Downtown
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Bozeman, Montana, Verenigde Staten, 59715
- Bozeman Deaconess Cancer Center
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Butte, Montana, Verenigde Staten, 59701
- St. James Healthcare Cancer Care
-
Great Falls, Montana, Verenigde Staten, 59405
- Great Falls Clinic - Main Facility
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Great Falls, Montana, Verenigde Staten, 59405
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Havre, Montana, Verenigde Staten, 59501
- Northern Montana Hospital
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Helena, Montana, Verenigde Staten, 59601
- St. Peter's Hospital
-
Kalispell, Montana, Verenigde Staten, 59901
- Kalispell Regional Medical Center
-
Kalispell, Montana, Verenigde Staten, 59901
- Glacier Oncology, PLLC
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Kalispell, Montana, Verenigde Staten, 59901
- Kalispell Medical Oncology at KRMC
-
Missoula, Montana, Verenigde Staten, 59801
- Community Medical Center
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Missoula, Montana, Verenigde Staten, 59804
- Guardian Oncology and Center for Wellness
-
Missoula, Montana, Verenigde Staten, 59807-7877
- Montana Cancer Specialists at Montana Cancer Center
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Missoula, Montana, Verenigde Staten, 59807
- Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
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Nebraska
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Lincoln, Nebraska, Verenigde Staten, 68510
- Cancer Resource Center - Lincoln
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Omaha, Nebraska, Verenigde Staten, 68106
- CCOP - Missouri Valley Cancer Consortium
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Omaha, Nebraska, Verenigde Staten, 68122
- Immanuel Medical Center
-
Omaha, Nebraska, Verenigde Staten, 68124
- Alegant Health Cancer Center at Bergan Mercy Medical Center
-
Omaha, Nebraska, Verenigde Staten, 68131-2197
- Creighton University Medical Center
-
-
North Carolina
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Rutherfordton, North Carolina, Verenigde Staten, 28139
- Rutherford Hospital
-
-
North Dakota
-
Bismarck, North Dakota, Verenigde Staten, 58501
- Bismarck Cancer Center
-
Bismarck, North Dakota, Verenigde Staten, 58501
- Medcenter One Hospital Cancer Care Center
-
Bismarck, North Dakota, Verenigde Staten, 58501
- Mid Dakota Clinic, PC
-
Bismarck, North Dakota, Verenigde Staten, 58502
- St. Alexius Medical Center Cancer Center
-
Fargo, North Dakota, Verenigde Staten, 58122
- CCOP - MeritCare Hospital
-
Fargo, North Dakota, Verenigde Staten, 58122
- MeritCare Broadway
-
Grand Forks, North Dakota, Verenigde Staten, 58201
- Altru Cancer Center at Altru Hospital
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Ohio
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Bellefontaine, Ohio, Verenigde Staten, 43311
- Mary Rutan Hospital
-
Bowling Green, Ohio, Verenigde Staten, 43402
- Wood County Oncology Center
-
Chillicothe, Ohio, Verenigde Staten, 45601
- Adena Regional Medical Center
-
Clyde, Ohio, Verenigde Staten, 43410
- North Coast Cancer Care - Clyde
-
Columbus, Ohio, Verenigde Staten, 43214-3998
- Riverside Methodist Hospital Cancer Care
-
Columbus, Ohio, Verenigde Staten, 43222
- Mount Carmel Health - West Hospital
-
Columbus, Ohio, Verenigde Staten, 43215
- CCOP - Columbus
-
Columbus, Ohio, Verenigde Staten, 43215
- Grant Medical Center Cancer Care
-
Columbus, Ohio, Verenigde Staten, 43228
- Doctors Hospital at Ohio Health
-
Dayton, Ohio, Verenigde Staten, 45405
- Grandview Hospital
-
Dayton, Ohio, Verenigde Staten, 45406
- Good Samaritan Hospital
-
Dayton, Ohio, Verenigde Staten, 45409
- David L. Rike Cancer Center at Miami Valley Hospital
-
Dayton, Ohio, Verenigde Staten, 45415
- Samaritan North Cancer Care Center
-
Dayton, Ohio, Verenigde Staten, 45420
- CCOP - Dayton
-
Delaware, Ohio, Verenigde Staten, 43015
- Grady Memorial Hospital
-
Elyria, Ohio, Verenigde Staten, 44035
- Hematology Oncology Center
-
Findlay, Ohio, Verenigde Staten, 45840
- Blanchard Valley Medical Associates
-
Franklin, Ohio, Verenigde Staten, 45005-1066
- Middletown Regional Hospital
-
Greenville, Ohio, Verenigde Staten, 45331
- Wayne Hospital
-
Kettering, Ohio, Verenigde Staten, 45429
- Charles F. Kettering Memorial Hospital
-
Lancaster, Ohio, Verenigde Staten, 43130
- Fairfield Medical Center
-
Lima, Ohio, Verenigde Staten, 45804
- Lima Memorial Hospital
-
Marietta, Ohio, Verenigde Staten, 45750
- Strecker Cancer Center at Marietta Memorial Hospital
-
Maumee, Ohio, Verenigde Staten, 43537
- St. Luke's Hospital
-
Maumee, Ohio, Verenigde Staten, 43537-1839
- Northwest Ohio Oncology Center
-
Newark, Ohio, Verenigde Staten, 43055
- Licking Memorial Cancer Care Program at Licking Memorial Hospital
-
Oregon, Ohio, Verenigde Staten, 43616
- St. Charles Mercy Hospital
-
Oregon, Ohio, Verenigde Staten, 43616
- Toledo Clinic - Oregon
-
Sandusky, Ohio, Verenigde Staten, 44870
- North Coast Cancer Care, Incorporated
-
Springfield, Ohio, Verenigde Staten, 45505
- Community Hospital of Springfield and Clark County
-
Springfield, Ohio, Verenigde Staten, 45504
- Mercy Medical Center
-
Sylvania, Ohio, Verenigde Staten, 43560
- Flower Hospital Cancer Center
-
Tiffin, Ohio, Verenigde Staten, 44883
- Mercy Hospital of Tiffin
-
Toledo, Ohio, Verenigde Staten, 43608
- St. Vincent Mercy Medical Center
-
Toledo, Ohio, Verenigde Staten, 43606
- Toledo Hospital
-
Toledo, Ohio, Verenigde Staten, 43614
- Medical University of Ohio Cancer Center
-
Toledo, Ohio, Verenigde Staten, 43617
- CCOP - Toledo Community Hospital
-
Toledo, Ohio, Verenigde Staten, 43623
- Toledo Clinic, Incorporated - Main Clinic
-
Toledo, Ohio, Verenigde Staten, 43623
- St. Anne Mercy Hospital
-
Troy, Ohio, Verenigde Staten, 45373-1300
- UVMC Cancer Care Center at Upper Valley Medical Center
-
Wauseon, Ohio, Verenigde Staten, 43567
- Fulton County Health Center
-
Westerville, Ohio, Verenigde Staten, 43081
- Mount Carmel St. Ann's Cancer Center
-
Wilmington, Ohio, Verenigde Staten, 45177
- Clinton Memorial Hospital
-
Xenia, Ohio, Verenigde Staten, 45385
- Ruth G. McMillan Cancer Center at Greene Memorial Hospital
-
Zanesville, Ohio, Verenigde Staten, 43701
- Genesis - Good Samaritan Hospital
-
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Pennsylvania
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Allentown, Pennsylvania, Verenigde Staten, 18105
- Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
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Danville, Pennsylvania, Verenigde Staten, 17822-0001
- Geisinger Cancer Institute at Geisinger Health
-
Hazleton, Pennsylvania, Verenigde Staten, 18201
- Geisinger Hazleton Cancer Center
-
State College, Pennsylvania, Verenigde Staten, 16801
- Geisinger Medical Group - Scenery Park
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Wilkes-Barre, Pennsylvania, Verenigde Staten, 18711
- Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
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South Carolina
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Anderson, South Carolina, Verenigde Staten, 29621
- AnMed Cancer Center
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Spartanburg, South Carolina, Verenigde Staten, 29303
- CCOP - Upstate Carolina
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Spartanburg, South Carolina, Verenigde Staten, 29303
- Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
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South Dakota
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Rapid City, South Dakota, Verenigde Staten, 57701
- Rapid City Regional Hospital
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Sioux Falls, South Dakota, Verenigde Staten, 57105
- Medical X-Ray Center, PC
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Sioux Falls, South Dakota, Verenigde Staten, 57117-5039
- Sanford Cancer Center at Sanford USD Medical Center
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Virginia
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Fredericksburg, Virginia, Verenigde Staten, 22401
- Fredericksburg Oncology, Incorporated
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Wisconsin
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Green Bay, Wisconsin, Verenigde Staten, 54307-3508
- St. Vincent Hospital Regional Cancer Center
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Green Bay, Wisconsin, Verenigde Staten, 54301-3526
- Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
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Green Bay, Wisconsin, Verenigde Staten, 54303
- Green Bay Oncology, Limited at St. Mary's Hospital
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Green Bay, Wisconsin, Verenigde Staten, 54303
- St. Mary's Hospital Medical Center - Green Bay
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Marinette, Wisconsin, Verenigde Staten, 54143
- Bay Area Cancer Care Center at Bay Area Medical Center
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Oconto Falls, Wisconsin, Verenigde Staten, 54154
- Green Bay Oncology, Limited - Oconto Falls
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Sturgeon Bay, Wisconsin, Verenigde Staten, 54235
- Green Bay Oncology, Limited - Sturgeon Bay
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Wyoming
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Casper, Wyoming, Verenigde Staten, 82609
- Rocky Mountain Oncology
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Sheridan, Wyoming, Verenigde Staten, 82801
- Welch Cancer Center at Sheridan Memorial Hospital
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Deelname Criteria
Geschiktheidscriteria
Leeftijden die in aanmerking komen voor studie
Accepteert gezonde vrijwilligers
Geslachten die in aanmerking komen voor studie
Beschrijving
Histologic confirmed diagnosis of malignant melanoma
- Stage IV disease
- Not amenable tosurgery
Measurable disease with at least one lesion whose longest diameter canbe measured as ≥ 20 mm by CT or MRI scans OR ≥ 10 mm by spiral CT
- No disease that is measurable by physical examination only
- No brain metastases per MRI or CT
- No radiographically documented invasion of adjacent organs(duodenum, stomach, etc.) or tumor invading major blood vessels
- ECOG performance status 0-1
- Life expectancy ≥ 4 months
- ANC ≥ 1,500/mm³
- Platelet count ≥ 100,000/mm³
- Hemoglobin ≥ 9 g/dL (transfusion allowed)
- Creatinine ≤ 1.5 times upper limit of normal (ULN)
- Total bilirubin ≤ 1.5 mg/dL (unless Gilbert syndrome)
- AST ≤ 2.5 times ULN
- Alkaline phosphatase ≤ 2.5 times ULN
- Urine protein:creatinine ratio < 1.0 at screening ORproteinuria < 2+ by urine dipstick or protein ≤ 1 g by 24-hour urine collection
- Negative serum pregnancy test
- Not pregnant or nursing
- Fertile patients must use effective contraception
- Active infection requiring parenteral antibiotics
- Poorly controlled high blood pressure (≥ 150 mm Hg systolic and/or100 mm Hg diastolic) despite treatment
- NYHA class II-IV congestive heart failure
- Serious cardiac arrhythmia requiring medication
- Myocardial infarction or unstable angina within the past 6 months
- Clinically significant peripheral vascular disease
- Deep venous thrombosis or pulmonary embolus within the past year
- Active bleeding or pathological conditions that carry high risk of bleeding (e.g., known esophageal varices)
- Serious, non-healing wound (including wounds healing by secondary intention), ulcer or bone fracture
- Abdominal fistula, gastrointestinal perforation, or intraabdominal abscess within the past 6 months
- History of CNS disease (e.g., primary brain tumor, vascular abnormalities, etc.)
- Clinically significant stroke or TIA within the past 6 months
- Seizures not controlled with standardmedical therapy
- Peripheral neuropathy ≥ grade 2
- History of other malignancy within the past 5 years except basal cell or squamous cell carcinoma of the skin treatable with local resection only or carcinoma in situ of the cervix
- Significant traumatic injury within the past 4 weeks
- History of hypertensive crisis or hypertensive encephalopathy
- Active or recent (≤ 30 days) history of hemoptysis (≥ ½ teaspoon of bright red blood per episode)
- Known hypersensitivity to any of the components of bevacizumab
- Known to be HIV positive
- Current or known history of hepatitis
- Prior adjuvant chemotherapy and/or immunotherapy for this cancer allowed
- No prior treatment with agents disrupting VEGF activity (i.e., bevacizumab,VEGF-trap, anti-VEGFR Mab)
- No ongoing need for full-dose oral or parenteral anticoagulation
- No ongoing anti-platelet treatment other than low-dose aspirin(i.e., aspirin 81 mg daily)
- No other investigational agents within the past 4 weeks
- No major surgical procedure or open biopsy within the past 4 weeks
- No fine needle aspirations or core biopsies within the past 7 days
- No prior chemotherapy in the metastatic setting
- No prior treatment with sunitinib malate or sorafenib
- No prior treatment with any taxane-based chemotherapy
- Patients who have had > 25% of their functional bone marrow irradiated are not eligible for this trial
- No adjuvant radiation therapy within the past 4 weeks
- More than 2 weeks since prior and no concurrent palliative radiation therapy
- No concurrent major surgical procedure
- No concurrent participation in another clinical study for procedures or agents that treat the same primary study malignancy
Studie plan
Hoe is de studie opgezet?
Ontwerpdetails
- Primair doel: Behandeling
- Toewijzing: Gerandomiseerd
- Interventioneel model: Parallelle opdracht
- Masker: Dubbele
Wapens en interventies
Deelnemersgroep / Arm |
Interventie / Behandeling |
---|---|
Experimenteel: Arm I
Patients receive oral temozolomide on days 1-5 and bevacizumab IV over 30-90 minutes on days 1 and 15.
|
Given IV over 30-90 minutes
Oral temozolomide on days 1-5
|
Experimenteel: Arm II
Patients receive bevacizumab IV over 30-90 minutes on days 1 and 15, paclitaxel albumin-stabilized nanoparticle formulation IV over 30 minutes on days 1, 8, and 15, and carboplatin IV over 30 minutes on day 1.
|
Given IV over 30-90 minutes
Given IV over 30 minutes
Given IV over 30 minutes
|
Wat meet het onderzoek?
Primaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
---|---|---|
Progression-free Survival at 6 Months
Tijdsspanne: at 6 months
|
The primary endpoint is the 6 month post registration Progression-free survival (PFS) rate.
Progression-free survival time is defined as the time from registration to documentation of disease progression using the RECIST criteria.
Patients who died without documentation of disease progression will be considered to have progressed at death unless there is sufficient documented evidence to conclude no progression occurred prior to death.
All patients, who meet the eligibility criteria, sign a consent form, and start treatment will be included in the evaluation of the 6 month PFS rate.
|
at 6 months
|
Secundaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
---|---|---|
Tumor Response Rate, Calculated as a Percentage Along With it's 95% Confidence Interval
Tijdsspanne: Up to 5 years
|
A confirmed tumor response is defined to be a Complete Response or Partial Response noted > as the objective status on 2 consecutive evaluations at least 8 > weeks apart. The proportion of tumor responses will be > estimated by the number of confirmed tumor responses divided > by the total number of evaluable patients. > Complete Response (CR): Disappearance of all target lesions > Partial Response (PR): At least a 30% decrease in the sum of the LD of target lesions taking as reference the baseline sum LD. > Progression (PD): At least a 20% increase in the sum of target lesions taking as reference the smallest sum LD recorded since the treatment started or the appearance of one or more new lesions. > Stable Disease (SD): Neither sufficient shrinkage to Qualify for PR nor sufficient increase to Qualify for PD taking as reference the smallest sum LD. responses will be calculated assuming that the number of > confirmed tumor responses follows a binomial distribution. |
Up to 5 years
|
Overall Survival
Tijdsspanne: Up to 5 years
|
Overall survival time is defined as the time from registration to death due to any cause.
The distribution of survival time will be estimated using the method of Kaplan-Meier.
|
Up to 5 years
|
Medewerkers en onderzoekers
Medewerkers
Publicaties en nuttige links
Studie record data
Bestudeer belangrijke data
Studie start
Primaire voltooiing (Werkelijk)
Studie voltooiing (Werkelijk)
Studieregistratiedata
Eerst ingediend
Eerst ingediend dat voldeed aan de QC-criteria
Eerst geplaatst (Schatting)
Updates van studierecords
Laatste update geplaatst (Werkelijk)
Laatste update ingediend die voldeed aan QC-criteria
Laatst geverifieerd
Meer informatie
Termen gerelateerd aan deze studie
Trefwoorden
Aanvullende relevante MeSH-voorwaarden
- Neoplasmata per histologisch type
- Neoplasmata
- Neuro-ectodermale tumoren
- Neoplasmata, kiemcellen en embryonaal
- Neoplasmata, zenuwweefsel
- Neuro-endocriene tumoren
- Nevi en melanomen
- Melanoma
- Fysiologische effecten van medicijnen
- Moleculaire mechanismen van farmacologische werking
- Antineoplastische middelen
- Tubuline-modulatoren
- Antimitotische middelen
- Mitose modulatoren
- Antineoplastische middelen, alkylering
- Alkyleringsmiddelen
- Antineoplastische middelen, fytogeen
- Antineoplastische middelen, immunologisch
- Angiogenese-remmers
- Angiogenese modulerende middelen
- Groei stoffen
- Groeiremmers
- Carboplatine
- Paclitaxel
- Temozolomide
- Bevacizumab
- Albumine-gebonden paclitaxel
Andere studie-ID-nummers
- NCCTG-N0775
- NCI-2009-00667 (Register-ID: CTRP (Clinical Trials Reporting System))
- CDR0000587708 (Register-ID: PDQ (Physician Data Query))
Deze informatie is zonder wijzigingen rechtstreeks van de website clinicaltrials.gov gehaald. Als u verzoeken heeft om uw onderzoeksgegevens te wijzigen, te verwijderen of bij te werken, neem dan contact op met register@clinicaltrials.gov. Zodra er een wijziging wordt doorgevoerd op clinicaltrials.gov, wordt deze ook automatisch bijgewerkt op onze website .
Klinische onderzoeken op Melanoom (Huid)
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Utah State UniversityActief, niet wervendOntvelling (skin-picking) stoornisVerenigde Staten
-
Ritamaria Di LorenzoVoltooidSKIN ADAPTOGEN EN SEBUM BALANCE EFFICIËNTIEItalië
-
Northwestern UniversityUniversity of Wisconsin, StoutVoltooidPerceptie van Skin of Color Clinics bij Afro-AmerikanenVerenigde Staten
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Karolinska InstitutetRegion StockholmVoltooidTrichotillomanie | Ontvelling (skin-picking) stoornisZweden
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National Taiwan University HospitalOnbekend
-
The Netherlands Cancer InstituteOnbekendStadium IV huidmelanoom | Oog; MelanomaNederland
-
University of AarhusDanish Cancer Society; AmbuFlexVoltooidMelanoma | Kwaliteit van het levenDenemarken
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Herlev HospitalVoltooidMelanoma | HuidkankerDenemarken
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Herlev HospitalVoltooidGeïntegreerde basiswetenschap binnen het instructieontwerp van patroonherkenningstraining (AISC-ISF)Melanoma | HuidkankerDenemarken
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University Medical Center GroningenWervingMelanoma | Hoofd- en nekneoplasmata | MSI-H-kankerNederland
Klinische onderzoeken op bevacizumab
-
National Cancer Institute (NCI)Actief, niet wervendRecidiverend eileidercarcinoom | Recidiverend ovariumcarcinoom | Recidiverend primair peritoneaal carcinoom | Ovarieel heldercellig cystadenocarcinoom | Ovarieel endometrioïde adenocarcinoom | Ovarieel sereus cystadenocarcinoom | Endometrium Clear Cell Adenocarcinoom | Endometrium sereus adenocarcinoom en andere voorwaardenVerenigde Staten
-
National Cancer Institute (NCI)VoltooidCervicaal adenocarcinoom | Cervicaal adenosquameus carcinoom | Cervicaal plaveiselcelcarcinoom, niet anders gespecificeerd | Stadium IVA Baarmoederhalskanker AJCC v6 en v7 | Recidiverend cervicaal carcinoom | Stadium IV Baarmoederhalskanker AJCC v6 en v7 | Stadium IVB Baarmoederhalskanker AJCC...Verenigde Staten
-
National Cancer Institute (NCI)NRG OncologyVoltooidBevacizumab met of zonder trebananib bij de behandeling van patiënten met terugkerende hersentumorenGlioblastoom | Gliosarcoom | Recidiverend glioblastoom | Oligodendroglioom | Gigantisch celglioblastoom | Terugkerend hersenneoplasmaVerenigde Staten, Canada
-
M.D. Anderson Cancer CenterWervingStadium IB Hepatocellulair carcinoom AJCC v8 | Stadium II hepatocellulair carcinoom AJCC v8 | Resectabel hepatocellulair carcinoom | Stadium I hepatocellulair carcinoom AJCC v8 | Stadium IA Hepatocellulair carcinoom AJCC v8Verenigde Staten
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Roswell Park Cancer InstituteNational Cancer Institute (NCI)WervingRecidiverend eileidercarcinoom | Recidiverend ovariumcarcinoom | Recidiverend primair peritoneaal carcinoom | Ovarieel endometrioïde adenocarcinoom | Ovarieel heldercellig adenocarcinoom | Eileider Clear Cell Adenocarcinoom | Endometrioïde adenocarcinoom van de eileider | Eileider Sereus Adenocarcinoom en andere voorwaardenVerenigde Staten
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National Cancer Institute (NCI)Actief, niet wervendOvarieel endometrioïde adenocarcinoom | Primair peritoneaal hooggradig sereus adenocarcinoom | Endometrioïde adenocarcinoom van de eileider | Platina-resistent eileidercarcinoom | Platina-resistent primair peritoneaal carcinoom | Hoogwaardig sereus adenocarcinoom van de eierstokken | Platina-resistent... en andere voorwaardenVerenigde Staten, Canada
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Northwestern UniversityNational Cancer Institute (NCI); Ipsen BiopharmaceuticalsVoltooidRecidiverend eileidercarcinoom | Recidiverend ovariumcarcinoom | Recidiverend primair peritoneaal carcinoom | Platina-resistent eileidercarcinoom | Platina-resistent primair peritoneaal carcinoom | Platina-resistent ovariumcarcinoom | Refractair ovariumcarcinoom | Refractair eileidercarcinoom | Refractair...Verenigde Staten
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National Cancer Institute (NCI)Actief, niet wervendStadium IV huidmelanoom AJCC v6 en v7 | Stadium IIIC Cutaan Melanoom AJCC v7 | Inoperabel melanoomVerenigde Staten
-
National Cancer Institute (NCI)Actief, niet wervendRecidiverend glioblastoomVerenigde Staten
-
Roswell Park Cancer InstituteNational Cancer Institute (NCI); Merck Sharp & Dohme LLC; Celldex TherapeuticsWervingRecidiverend eileidercarcinoom | Recidiverend ovariumcarcinoom | Recidiverend primair peritoneaal carcinoom | Recidiverend endometrium sereus adenocarcinoom | Ovarieel heldercellig adenocarcinoom | Recidiverend platinaresistent ovariumcarcinoom | Platinagevoelig ovariumcarcinoom | Recidiverend endometrioïde... en andere voorwaardenVerenigde Staten