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Hidden Hearing Loss in Older Adults

9 juni 2026 bijgewerkt door: Ying Chen, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Hidden Hearing Loss in Older Adults: Mechanisms of Speech-in-noise Perception Deficits and Associated Central Compensation

The goal of this observational study is to investigate whether speech-in-noise perception deficits in older adults aged 60 years or older with objectively normal hearing thresholds are due to impaired ability of processing temporal cues in speech signals. The study further aims to examine whether cognitive and cortical mechanisms provide compensatory support for speech perception in challenging listening environments.

Studie Overzicht

Toestand

Werving

Conditie

Gedetailleerde beschrijving

This observational study aims to investigate the peripheral auditory mechanisms underlying speech-in-noise perception deficits in older adults with hidden hearing loss, as well as the potential central compensatory mechanisms involved. The study will recruit community-dwelling adults aged 60 years and older who has objectively normal hearing thresholds on pure-tone audiometry but self-report difficulties understanding speech in noisy or complex listening environments.

The investigators hypothesize that speech-in-noise perception deficits in these individuals are associated with impaired ability of processing temporal cues in speech signals under challenging listening conditions. The investigators further hypothesize that cortical mechanisms involved in speech-in-noise processing may be recruited to facilitate speech understanding, although the extent of such compensation in the aging brain may vary across individuals.

The study will collect demographic, lifestyle, and health-related information. Participants will undergo comprehensive audiological assessments, neurophysiological testing, behavioral evaluations, and neuroimaging examinations. These measures will be used to characterize the ability of the peripheral auditory system to process temporal acoustic information and to investigate potential central compensatory mechanisms associated with speech perception in complex listening environments.

Studietype

Observationeel

Inschrijving (Geschat)

200

Contacten en locaties

In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.

Studiecontact

Studie Locaties

  • China
    • Shanghai Municipality
      • Shanghai, Shanghai Municipality, China, 200011
        • Werving
        • Department of Otorhinolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University School of Medicine, Shanghai, China
        • Contact:

Deelname Criteria

Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.

Geschiktheidscriteria

Leeftijden die in aanmerking komen voor studie

  • Volwassen
  • Oudere volwassene

Accepteert gezonde vrijwilligers

Nee

Bemonsteringsmethode

Niet-waarschijnlijkheidssteekproef

Studie Bevolking

Community-dwelling adults aged 60 years and older residing in Shanghai, who has objectively normal hearing thresholds on pure-tone audiometry but self-report difficulties understanding speech in noisy or complex listening environments.

Beschrijving

Inclusion Criteria:

  1. Aged 60 years or older;
  2. Bilateral pure-tone average hearing thresholds across 0.5, 1, 2, and 4 kHz ≤ 25 dB HL;
  3. Self-reported hearing difficulties identified during previous hearing screening;
  4. Fluent in Mandarin Chinese;
  5. No history of otologic disease, ear trauma, ototoxic medication history, or long-term noise exposure;
  6. No known neurological or psychiatric disorders, or other major medical conditions that may affect nervous system function.

Exclusion Criteria:

  1. Unable to comply with or complete the study assessments;
  2. Mini-Mental State Examination (MMSE) score < 24 during previous health screening;
  3. Refuse to participate in the study

Studie plan

Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.

Hoe is de studie opgezet?

Ontwerpdetails

Cohorten en interventies

Groep / Cohort
older adults with hidden hearing loss
adults aged 60 years and older who has objectively normal hearing thresholds on pure-tone audiometry but self-report difficulties understanding speech in noisy or complex listening environments.

Wat meet het onderzoek?

Primaire uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
Conventional pure-tone audiometry (PTA) with extended high-frequency (0.25-16 kHz)
Tijdsspanne: Participants will complete all study assessments within one month of enrollment.
This measure reflects the overall audibility of the individual. Together with the other measures listed under the primary outcome measure, it provides a comprehensive assessment of participants' peripheral auditory function.
Participants will complete all study assessments within one month of enrollment.
Gap Detection Test (GDT)
Tijdsspanne: Participants will complete all study assessments within one month of enrollment.
This behavioral test assesses an individual's ability to detect brief silent gaps in an auditory signal, reflecting temporal resolution within the auditory system
Participants will complete all study assessments within one month of enrollment.
Distortion Product Otoacoustic Emissions (DPOAEs)
Tijdsspanne: Participants will complete all study assessments within one month of enrollment.
This objective measure evaluates cochlear outer hair cell. Together with the other measures listed under the primary outcome measure, it provides a comprehensive assessment of participants' peripheral auditory function.
Participants will complete all study assessments within one month of enrollment.
Electrocochleography
Tijdsspanne: Participants will complete all study assessments within one month of enrollment.
This objective measure assesses cochlear and auditory nerve function. Together with the other measures listed under the primary outcome measure, it provides a comprehensive assessment of participants' peripheral auditory function.
Participants will complete all study assessments within one month of enrollment.
Auditory Brainstem Response (ABR)
Tijdsspanne: Participants will complete all study assessments within one month of enrollment.
This objective measure assesses auditory nerve and brainstem function. Together with the other measures listed under the primary outcome measure, it provides a comprehensive assessment of participants' peripheral auditory function.
Participants will complete all study assessments within one month of enrollment.
Frequency-Following Response (FFR)
Tijdsspanne: Participants will complete all study assessments within one month of enrollment.
This objective measure assesses the neural encoding of sound by recording phase-locked neural responses to auditory stimuli. It reflects the ability of the auditory system to encode and resolve temporal information.
Participants will complete all study assessments within one month of enrollment.
Central neural activity during Memory task measured by fMRI
Tijdsspanne: Participants will complete all study assessments within one month of enrollment
Participants will complete all study assessments within one month of enrollment
Central neural activity during listening task measured by fMRI
Tijdsspanne: Participants will complete all study assessments within one month of enrollment.
Participants will complete all study assessments within one month of enrollment.

Secundaire uitkomstmaten

Uitkomstmaat
Tijdsspanne
Depressive symptoms assessed using the Patient Health Questionnaire-9 (PHQ-9)
Tijdsspanne: Participants will complete all study assessments within one month of enrollment
Participants will complete all study assessments within one month of enrollment
Anxiety symptoms assessed using the Generalized Anxiety Disorder-7 (GAD-7)
Tijdsspanne: Participants will complete all study assessments within one month of enrollment.
Participants will complete all study assessments within one month of enrollment.
Cognitive function assessed using Digit Span test.
Tijdsspanne: Participants will complete all study assessments within one month of enrollment.
Participants will complete all study assessments within one month of enrollment.

Medewerkers en onderzoekers

Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.

Sponsor

Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Studie record data

Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.

Bestudeer belangrijke data

Studie start (Geschat)

15 juni 2026

Primaire voltooiing (Geschat)

1 mei 2027

Studie voltooiing (Geschat)

30 mei 2027

Studieregistratiedata

Eerst ingediend

3 juni 2026

Eerst ingediend dat voldeed aan de QC-criteria

9 juni 2026

Eerst geplaatst (Werkelijk)

12 juni 2026

Updates van studierecords

Laatste update geplaatst (Werkelijk)

12 juni 2026

Laatste update ingediend die voldeed aan QC-criteria

9 juni 2026

Laatst geverifieerd

1 juni 2026

Meer informatie

Termen gerelateerd aan deze studie

Trefwoorden

Aanvullende relevante MeSH-voorwaarden

Andere studie-ID-nummers

  • SH9H-2026-T21-2

Plan Individuele Deelnemersgegevens (IPD)

Bent u van plan om gegevens van individuele deelnemers (IPD) te delen?

JA

Beschrijving IPD-plan

IPD used in the results publication will be shared.

IPD-tijdsbestek voor delen

IPD and supporting information will be available for 5 years following publication.

IPD delen Ondersteunend informatietype

  • LEERPROTOCOOL
  • SAP
  • ICF

Informatie over medicijnen en apparaten, studiedocumenten

Bestudeert een door de Amerikaanse FDA gereguleerd geneesmiddel

Nee

Bestudeert een door de Amerikaanse FDA gereguleerd apparaatproduct

Nee

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