Is COPD a Risk Factor for Cardiovascular Disease?
Is Chronic Obstructive Pulmonary Disease a Risk Factor for Cardiovascular Disease?
Studieoversikt
Status
Forhold
Detaljert beskrivelse
Patients with chronic obstructive pulmonary disease (COPD) suffer from significant cardiovascular morbidity and mortality. Coronary artery disease has often been linked causally to COPD, but the exact pathophysiological mechanisms underpinning this association remain speculative. A retrospective case-control study matching COPD patients and controls one to one for smoking history and conventional cardiovascular risk factors will be performed to study the association between COPD and cardiovascular outcomes. Filling in this knowledge gap may contribute to the understanding of the interplay between COPD and cardiovascular disease.
The objective of this retrospective case-control study is to determine whether COPD might be a risk factor for coronary atherosclerosis, impaired left ventricular ejection fraction, and major adverse cardiovascular events independent of conventional cardiovascular risk factors.
Studietype
Registrering (Faktiske)
Kontakter og plasseringer
Studiesteder
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Zurich, Sveits, 8091
- University Hospital Zurich, Pulmonary Division
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Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
- Barn
- Voksen
- Eldre voksen
Tar imot friske frivillige
Kjønn som er kvalifisert for studier
Prøvetakingsmetode
Studiepopulasjon
Beskrivelse
Inclusion Criteria:
- SPECT-CT imaging due to preoperative assessment between 01.01.2007 and 31.07.2013.
- Coronary artery calcium score and left ventricular ejection fraction data available.
- History of smoking (smoker or ex-smoker).
- COPD group: Documented chronic obstructive pulmonary disease (post-bronchodilator FEV1/FVC < 0.7).
- Control group: Exclusion of chronic obstructive pulmonary disease (post-bronchodilator FEV1/FVC > 0.7).
Exclusion Criteria:
- Known coronary artery disease or coronary symptoms (angina pectoris) at the time of the SPECT-CT investigation.
- Known congenital or structural heart disease.
- Previous heart transplantation.
Studieplan
Hvordan er studiet utformet?
Designdetaljer
Kohorter og intervensjoner
Gruppe / Kohort |
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Chronic obstructive pulmonary disease
Approximately 100 participants with documented chronic obstructive pulmonary disease (post-bronchodilator Forced expiratory volume in 1 second (FEV1)/Forced vital capacity (FVC) < 0.7).
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Control
Approximately 100 participants with exclusion of chronic obstructive pulmonary disease (post-bronchodilator Forced expiratory volume in 1 second (FEV1)/Forced vital capacity (FVC) > 0.7).
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Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
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Coronary calcium score in cardiac computed tomography
Tidsramme: Up to one month
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Retrospective assessment of SPECT-CT imaging data at the University Hospital Zurich.
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Up to one month
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Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
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Left ventricular ejection fraction in single-photon emission computed tomography
Tidsramme: Up to one month
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Retrospective assessment of SPECT-CT imaging data at the University Hospital Zurich.
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Up to one month
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Major adverse cardiovascular events
Tidsramme: Up to three months
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Follow-up via telephone interview for major adverse cardiovascular events.
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Up to three months
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Samarbeidspartnere og etterforskere
Sponsor
Samarbeidspartnere
Etterforskere
- Hovedetterforsker: Malcolm Kohler, MD, Prof, University of Zurich
Studierekorddatoer
Studer hoveddatoer
Studiestart
Primær fullføring (Faktiske)
Studiet fullført (Faktiske)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Anslag)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Anslag)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- SNCTP000000995
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