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Brain Cognitive Network Abnormalities in Anemia Patients Using fNIRS (AN-CNA)

15. september 2026 oppdatert av: Institute of Hematology & Blood Diseases Hospital, China

Construction of Abnormal Projection Regions of Cognitive Neural Networks in Patients With Anemia Using Functional Near-Infrared Spectroscopy (fNIRS)

Anemia is a global public health concern and is closely linked to dysfunction of brain cognitive neural networks, a key mechanism underlying cognitive impairment. Such deficits-including declines in memory, learning, processing speed, and executive function-reduce daily living abilities and increase risks of falls and depression.

Functional near-infrared spectroscopy (fNIRS) enables real-time monitoring of oxygenated and deoxygenated hemoglobin fluctuations, reflecting brain network function. This study aims to identify affected neural network regions in anemic patients and visualize connectivity changes using heatmaps and arc-based mapping. The findings will support early detection of cognitive impairment and guide precise clinical interventions, ultimately informing individualized treatment strategies to enhance therapeutic outcomes and quality of life.

Studieoversikt

Status

Rekruttering

Forhold

Studietype

Observasjonsmessig

Registrering (Antatt)

323

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiekontakt

Navn: ZheXiang Kuang, MSN
Telefonnummer: 13920361752
E-post: kuangzhexiang@ihcams.ac.cn

Studer Kontakt Backup

Navn: Xiao Yu, Undergraduate
Telefonnummer: 18722218448
E-post: yuxiao@ihcams.ac.cn

Studiesteder

Kina
- Tianjin Municipality
  - Tianjin, Tianjin Municipality, Kina
    - Rekruttering
    - Regenerative Medicine Center
    - Ta kontakt med:
      
      Xiao Yu, Undergraduate
      
      Telefonnummer: 18722218448
      
      E-post: yuxiao@ihcams.ac.cn

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

Voksen
Eldre voksen

Tar imot friske frivillige

Nei

Prøvetakingsmetode

Ikke-sannsynlighetsprøve

Studiepopulasjon

Patients with anemia who were hospitalized for the first time during the period from 2026 to 2028.

Beskrivelse

Inclusion Criteria:

Diagnosis of anemia
First hospitalization
Male or female, aged 18-65 years
Willing and able to comply with the requirements for this study and written informed consent

Exclusion Criteria:

History of psychiatric illness
History of severe brain disease
Subjects that the investigator believes have other reasons that make them unsuitable for inclusion in this study

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

Hva måler studien?

Primære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Concentration changes in oxygenated hemoglobin (HbO) and de-oxygenated hemoglobin (HbR) Tidsramme: Patients will be assessed within 48 hours of admission.	Functional Near Infrared Spectroscopy (fNIRS) is a non-invasive brain imaging modality, that can be used to measure HbO and HbR concentrations.	Patients will be assessed within 48 hours of admission.
Cognitive Function Assessment Tidsramme: Patients will be assessed within 48 hours of admission.	Montreal Cognitive Assessment (MoCA) is used to assess cognitive function in patients, with higher total scores indicating better cognitive function. The total score range is 0 to 30.	Patients will be assessed within 48 hours of admission.

Sekundære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Anxiety symptoms Tidsramme: Patients will be assessed within 48 hours of admission.	Hamilton anxiety scale(HAMA) is used to examine anxiety in AIHA patients, with higher total scores indicate more severe anxiety symptoms. The total score range is 0-56.	Patients will be assessed within 48 hours of admission.
Depression symptoms Tidsramme: Patients will be assessed within 48 hours of admission.	Hamilton depression scale(HAMD) is used to examine depression in AIHA patients, with higher total scores indicate more severe depression symptoms. The total score range is 0-52.	Patients will be assessed within 48 hours of admission.
Sleep quality Tidsramme: Patients will be assessed within 48 hours of admission.	The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality, with a higher global score indicating poorer sleep quality. The global score range is 0-21.	Patients will be assessed within 48 hours of admission.
Physical fatigue Tidsramme: Patients will be assessed within 48 hours of admission.	It measured by the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) Scale. The total possible score is 0-52 points, with higher scores indicating less fatigue.	Patients will be assessed within 48 hours of admission.
Appetite condition Tidsramme: Patients will be assessed within 48 hours of admission.	Simplified Nutritional Appetite Questionnaire (SNAQ) is used to assess appetite in patients, with higher total scores indicating better appetite. The total score range is 4 to 20.	Patients will be assessed within 48 hours of admission.

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Institute of Hematology & Blood Diseases Hospital, China

Samarbeidspartnere

Tianjin University

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

11. oktober 2025

Primær fullføring (Antatt)

31. mars 2028

Studiet fullført (Antatt)

31. desember 2028

Datoer for studieregistrering

Først innsendt

5. mai 2026

Først innsendt som oppfylte QC-kriteriene