Effect of Preoperative Periodontal Treatment on Postoperative Infection and Mortality After Aortic and Mitral Valve Surgery (Perio-CVS)
31. mai 2026 oppdatert av: Mehmet Selim Yildiz, Istanbul University - Cerrahpasa
Effect of Preoperative Periodontal Treatment on Postoperative Infection and Mortality in Patients Undergoing Aortic and Mitral Valve Surgery: A Retrospective Study
This retrospective observational study aims to evaluate the effect of preoperative periodontal treatment on postoperative infection and mortality in patients undergoing aortic and mitral valve surgery.
Patient records between 2015 and 2024 analyzed. Demographic, clinical, and and radiographic findings, evaluated. Postoperative outcomes such as infection, antibiotic use, length of hospital and intensive care unit stay, and mortality assessed.
The findings of this study may contribute to understanding the role of periodontal health in improving postoperative outcomes in cardiac surgery patients.
Studieoversikt
Status
Fullført
Detaljert beskrivelse
Periodontitis is a chronic inflammatory disease that has been associated with various systemic conditions, including cardiovascular diseases and infective endocarditis. Oral pathogens and inflammatory mediators originating from periodontal tissues may enter the bloodstream and contribute to systemic inflammation and postoperative complications.
This retrospective observational study includes patients aged 18 years and older who underwent aortic and mitral valve surgery and received or not periodontal treatment within 15 days prior to surgery. Patient records from 2015 to 2024 has been reviewed. Inclusion and exclusion criteria has been applied to ensure data consistency and reliability.
Collected data included demographic characteristics, medical history, periodontal disease stages, DMFT scores, and radiographic findings. Postoperative variables such as infection status, antibiotic use, duration of hospitalization, intensive care unit stay, and mortality has been evaluated.
Statistical analyses performed using appropriate parametric and non-parametric tests. Multivariate regression models used to identify factors associated with postoperative infection and mortality.
The aim of this study is to determine whether preoperative periodontal treatment has a significant impact on postoperative outcomes in patients undergoing cardiac valve surgery.
Studietype
Observasjonsmessig
Registrering (Faktiske)
200
Kontakter og plasseringer
Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.
Studiesteder
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Bakirköy
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Istanbul, Bakirköy, Tyrkia (Türkiye), 34147
- Bakirköy Dr. Sadi Konuk Education and Research Hospital
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Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
- Voksen
- Eldre voksen
Tar imot friske frivillige
Nei
Prøvetakingsmetode
Ikke-sannsynlighetsprøve
Studiepopulasjon
This retrospective study population consists of adult patients who underwent cardiac valve surgery and had available preoperative panoramic radiographs and complete clinical records.
The study aims to evaluate the association between oral health status (DMFT index and radiographic periodontal condition) and postoperative clinical outcomes.
Beskrivelse
Inclusion Criteria:
- Adult patients (≥18 years) who underwent cardiac valve surgery
- Availability of preoperative panoramic radiographs
- Complete medical and dental records, including DMFT index and systemic clinical parameters
- Patients with documented postoperative clinical follow-up data
Exclusion Criteria:
- Patients under 18 years of age
- Patients with incomplete or missing medical or radiographic records
- Patients with a history of systemic conditions severely affecting bone metabolism (e.g., advanced malignancy, metabolic bone disease)
- Patients who received recent periodontal treatment prior to radiographic assessment
- Poor-quality radiographs that do not allow accurate evaluation
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
Kohorter og intervensjoner
Gruppe / Kohort |
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Elective Surgery Patients
This cohort includes patients who underwent elective aortic or mitral valve surgery and had complete medical and dental records available.
All patients received standard preoperative evaluation, and those with documented periodontal treatment within 15 days prior to surgery were included.
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Emergency Surgery Patients
This cohort consists of patients who underwent emergency aortic or mitral valve surgery.
Due to the urgent nature of the procedure, preoperative periodontal assessment and treatment not have been consistently performed.
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Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
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Radiographic Alveolar Bone Loss Percentage Assessed on Panoramic Radiographs
Tidsramme: Preoperative assessment (baseline)
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Radiographic periodontal bone loss have been assessed on panoramic radiographs by measuring the percentage of alveolar bone loss relative to root length.
Bone loss severity will be categorized according to the extent of radiographic alveolar bone loss.
Higher percentages indicate greater periodontal destruction and more severe periodontal disease.
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Preoperative assessment (baseline)
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Periodontal disease diagnosis (presence and severity)
Tidsramme: Preoperative assessment (baseline)
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Periodontal disease diagnosed based on radiographic findings and classified according to established periodontal disease criteria (e.g., mild, moderate, or severe periodontitis).
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Preoperative assessment (baseline)
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DMFT index (Decayed, Missing, Filled Teeth score)
Tidsramme: Preoperative assessment (baseline)
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The DMFT index calculated from radiographic and clinical records to quantify cumulative dental caries experience in each patient.
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Preoperative assessment (baseline)
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Postoperative infection-related clinical outcomes (fever duration)
Tidsramme: Measured within the first 7 postoperative days following cardiac surgery.
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The number of days with postoperative fever (≥37.5°C)
recorded from patient medical records and used as an indicator of postoperative infection.
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Measured within the first 7 postoperative days following cardiac surgery.
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Length of postoperative hospital stay (days)
Tidsramme: From the date of cardiac surgery until hospital discharge, assessed up to 30 days postoperatively.
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The duration of hospitalization has been recorded in days from the date of cardiac surgery until hospital discharge and compared according to preoperative oral and periodontal status.
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From the date of cardiac surgery until hospital discharge, assessed up to 30 days postoperatively.
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Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
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Duration of intensive care unit (ICU) stay (days)
Tidsramme: From admission to the intensive care unit following cardiac surgery until ICU discharge, assessed up to 30 days postoperatively.
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The number of days spent in the intensive care unit following cardiac surgery recorded and analyzed according to preoperative oral and periodontal health status.
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From admission to the intensive care unit following cardiac surgery until ICU discharge, assessed up to 30 days postoperatively.
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Time to initiation of oral feeding (days)
Tidsramme: From the date of cardiac surgery until initiation of oral feeding, assessed up to 30 days postoperatively.
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The number of days from cardiac surgery to the initiation of oral feeding recorded and evaluated as an indicator of postoperative recovery.
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From the date of cardiac surgery until initiation of oral feeding, assessed up to 30 days postoperatively.
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Postoperative C-Reactive Protein (CRP) Level
Tidsramme: Measured within the first 7 postoperative days following cardiac surgery.
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Serum C-reactive protein (CRP) concentration, measured in milligrams per liter (mg/L), obtained from medical records and analyzed as an indicator of postoperative systemic inflammatory response.
Higher values indicate a greater inflammatory response.
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Measured within the first 7 postoperative days following cardiac surgery.
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Postoperative White Blood Cell (WBC) Count
Tidsramme: Measured within the first 7 postoperative days following cardiac surgery.
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White blood cell count, measured in ×10⁹ cells/L, obtained from medical records and analyzed as an indicator of postoperative systemic inflammatory response.
Higher values indicate a greater inflammatory response.
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Measured within the first 7 postoperative days following cardiac surgery.
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Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Sponsor
Publikasjoner og nyttige lenker
Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.
Generelle publikasjoner
- Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol. 2015 Jan;15(1):30-44. doi: 10.1038/nri3785.
- Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP 3rd, Fleisher LA, Jneid H, Mack MJ, McLeod CJ, O'Gara PT, Rigolin VH, Sundt TM 3rd, Thompson A. 2017 AHA/ACC Focused Update of the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2017 Jul 11;70(2):252-289. doi: 10.1016/j.jacc.2017.03.011. Epub 2017 Mar 15. No abstract available.
- Nakano K, Nemoto H, Nomura R, Inaba H, Yoshioka H, Taniguchi K, Amano A, Ooshima T. Detection of oral bacteria in cardiovascular specimens. Oral Microbiol Immunol. 2009 Feb;24(1):64-8. doi: 10.1111/j.1399-302X.2008.00479.x.
- Sfyroeras GS, Roussas N, Saleptsis VG, Argyriou C, Giannoukas AD. Association between periodontal disease and stroke. J Vasc Surg. 2012 Apr;55(4):1178-84. doi: 10.1016/j.jvs.2011.10.008. Epub 2012 Jan 14.
- Saengtipbovorn S, Taneepanichskul S. Effectiveness of lifestyle change plus dental care (LCDC) program on improving glycemic and periodontal status in the elderly with type 2 diabetes. BMC Oral Health. 2014 Jun 16;14:72. doi: 10.1186/1472-6831-14-72.
- Bagyi K, Haczku A, Marton I, Szabo J, Gaspar A, Andrasi M, Varga I, Toth J, Klekner A. Role of pathogenic oral flora in postoperative pneumonia following brain surgery. BMC Infect Dis. 2009 Jun 29;9:104. doi: 10.1186/1471-2334-9-104.
Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart (Faktiske)
1. januar 2015
Primær fullføring (Faktiske)
1. desember 2024
Studiet fullført (Faktiske)
1. mai 2025
Datoer for studieregistrering
Først innsendt
19. mai 2026
Først innsendt som oppfylte QC-kriteriene
31. mai 2026
Først lagt ut (Faktiske)
4. juni 2026
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
4. juni 2026
Siste oppdatering sendt inn som oppfylte QC-kriteriene
31. mai 2026
Sist bekreftet
1. mai 2026
Mer informasjon
Begreper knyttet til denne studien
Nøkkelord
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- 2025/168
Plan for individuelle deltakerdata (IPD)
Planlegger du å dele individuelle deltakerdata (IPD)?
JA
IPD-planbeskrivelse
De-identified participant data including questionnaire responses and periodontal measurements will be available upon reasonable request after publication.
IPD-deling Støtteinformasjonstype
- STUDY_PROTOCOL
- ICF
- ANALYTIC_CODE
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Nei
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