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Effect of Preoperative Periodontal Treatment on Postoperative Infection and Mortality After Aortic and Mitral Valve Surgery (Perio-CVS)

31. maj 2026 opdateret af: Mehmet Selim Yildiz, Istanbul University - Cerrahpasa

Effect of Preoperative Periodontal Treatment on Postoperative Infection and Mortality in Patients Undergoing Aortic and Mitral Valve Surgery: A Retrospective Study

This retrospective observational study aims to evaluate the effect of preoperative periodontal treatment on postoperative infection and mortality in patients undergoing aortic and mitral valve surgery.

Patient records between 2015 and 2024 analyzed. Demographic, clinical, and and radiographic findings, evaluated. Postoperative outcomes such as infection, antibiotic use, length of hospital and intensive care unit stay, and mortality assessed.

The findings of this study may contribute to understanding the role of periodontal health in improving postoperative outcomes in cardiac surgery patients.

Studieoversigt

Status

Afsluttet

Betingelser

Detaljeret beskrivelse

Periodontitis is a chronic inflammatory disease that has been associated with various systemic conditions, including cardiovascular diseases and infective endocarditis. Oral pathogens and inflammatory mediators originating from periodontal tissues may enter the bloodstream and contribute to systemic inflammation and postoperative complications.

This retrospective observational study includes patients aged 18 years and older who underwent aortic and mitral valve surgery and received or not periodontal treatment within 15 days prior to surgery. Patient records from 2015 to 2024 has been reviewed. Inclusion and exclusion criteria has been applied to ensure data consistency and reliability.

Collected data included demographic characteristics, medical history, periodontal disease stages, DMFT scores, and radiographic findings. Postoperative variables such as infection status, antibiotic use, duration of hospitalization, intensive care unit stay, and mortality has been evaluated.

Statistical analyses performed using appropriate parametric and non-parametric tests. Multivariate regression models used to identify factors associated with postoperative infection and mortality.

The aim of this study is to determine whether preoperative periodontal treatment has a significant impact on postoperative outcomes in patients undergoing cardiac valve surgery.

Undersøgelsestype

Observationel

Tilmelding (Faktiske)

200

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Tyrkiet (Türkiye)
    • Bakirköy
      • Istanbul, Bakirköy, Tyrkiet (Türkiye), 34147
        • Bakirköy Dr. Sadi Konuk Education and Research Hospital

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Voksen
  • Ældre voksen

Tager imod sunde frivillige

Ingen

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

This retrospective study population consists of adult patients who underwent cardiac valve surgery and had available preoperative panoramic radiographs and complete clinical records. The study aims to evaluate the association between oral health status (DMFT index and radiographic periodontal condition) and postoperative clinical outcomes.

Beskrivelse

Inclusion Criteria:

  • Adult patients (≥18 years) who underwent cardiac valve surgery
  • Availability of preoperative panoramic radiographs
  • Complete medical and dental records, including DMFT index and systemic clinical parameters
  • Patients with documented postoperative clinical follow-up data

Exclusion Criteria:

  • Patients under 18 years of age
  • Patients with incomplete or missing medical or radiographic records
  • Patients with a history of systemic conditions severely affecting bone metabolism (e.g., advanced malignancy, metabolic bone disease)
  • Patients who received recent periodontal treatment prior to radiographic assessment
  • Poor-quality radiographs that do not allow accurate evaluation

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Kohorter og interventioner

Gruppe / kohorte
Elective Surgery Patients
This cohort includes patients who underwent elective aortic or mitral valve surgery and had complete medical and dental records available. All patients received standard preoperative evaluation, and those with documented periodontal treatment within 15 days prior to surgery were included.
Emergency Surgery Patients
This cohort consists of patients who underwent emergency aortic or mitral valve surgery. Due to the urgent nature of the procedure, preoperative periodontal assessment and treatment not have been consistently performed.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Radiographic Alveolar Bone Loss Percentage Assessed on Panoramic Radiographs
Tidsramme: Preoperative assessment (baseline)
Radiographic periodontal bone loss have been assessed on panoramic radiographs by measuring the percentage of alveolar bone loss relative to root length. Bone loss severity will be categorized according to the extent of radiographic alveolar bone loss. Higher percentages indicate greater periodontal destruction and more severe periodontal disease.
Preoperative assessment (baseline)
Periodontal disease diagnosis (presence and severity)
Tidsramme: Preoperative assessment (baseline)
Periodontal disease diagnosed based on radiographic findings and classified according to established periodontal disease criteria (e.g., mild, moderate, or severe periodontitis).
Preoperative assessment (baseline)
DMFT index (Decayed, Missing, Filled Teeth score)
Tidsramme: Preoperative assessment (baseline)
The DMFT index calculated from radiographic and clinical records to quantify cumulative dental caries experience in each patient.
Preoperative assessment (baseline)
Postoperative infection-related clinical outcomes (fever duration)
Tidsramme: Measured within the first 7 postoperative days following cardiac surgery.
The number of days with postoperative fever (≥37.5°C) recorded from patient medical records and used as an indicator of postoperative infection.
Measured within the first 7 postoperative days following cardiac surgery.
Length of postoperative hospital stay (days)
Tidsramme: From the date of cardiac surgery until hospital discharge, assessed up to 30 days postoperatively.
The duration of hospitalization has been recorded in days from the date of cardiac surgery until hospital discharge and compared according to preoperative oral and periodontal status.
From the date of cardiac surgery until hospital discharge, assessed up to 30 days postoperatively.

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Duration of intensive care unit (ICU) stay (days)
Tidsramme: From admission to the intensive care unit following cardiac surgery until ICU discharge, assessed up to 30 days postoperatively.
The number of days spent in the intensive care unit following cardiac surgery recorded and analyzed according to preoperative oral and periodontal health status.
From admission to the intensive care unit following cardiac surgery until ICU discharge, assessed up to 30 days postoperatively.
Time to initiation of oral feeding (days)
Tidsramme: From the date of cardiac surgery until initiation of oral feeding, assessed up to 30 days postoperatively.
The number of days from cardiac surgery to the initiation of oral feeding recorded and evaluated as an indicator of postoperative recovery.
From the date of cardiac surgery until initiation of oral feeding, assessed up to 30 days postoperatively.
Postoperative C-Reactive Protein (CRP) Level
Tidsramme: Measured within the first 7 postoperative days following cardiac surgery.
Serum C-reactive protein (CRP) concentration, measured in milligrams per liter (mg/L), obtained from medical records and analyzed as an indicator of postoperative systemic inflammatory response. Higher values indicate a greater inflammatory response.
Measured within the first 7 postoperative days following cardiac surgery.
Postoperative White Blood Cell (WBC) Count
Tidsramme: Measured within the first 7 postoperative days following cardiac surgery.
White blood cell count, measured in ×10⁹ cells/L, obtained from medical records and analyzed as an indicator of postoperative systemic inflammatory response. Higher values indicate a greater inflammatory response.
Measured within the first 7 postoperative days following cardiac surgery.

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Istanbul University - Cerrahpasa

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

1. januar 2015

Primær færdiggørelse (Faktiske)

1. december 2024

Studieafslutning (Faktiske)

1. maj 2025

Datoer for studieregistrering

Først indsendt

19. maj 2026

Først indsendt, der opfyldte QC-kriterier

31. maj 2026

Først opslået (Faktiske)

4. juni 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

4. juni 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

31. maj 2026

Sidst verificeret

1. maj 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • 2025/168

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

JA

IPD-planbeskrivelse

De-identified participant data including questionnaire responses and periodontal measurements will be available upon reasonable request after publication.

IPD-deling Understøttende informationstype

  • STUDY_PROTOCOL
  • ICF
  • ANALYTIC_CODE

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