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Effect of Preoperative Periodontal Treatment on Postoperative Infection and Mortality After Aortic and Mitral Valve Surgery (Perio-CVS)

31 mei 2026 bijgewerkt door: Mehmet Selim Yildiz, Istanbul University - Cerrahpasa

Effect of Preoperative Periodontal Treatment on Postoperative Infection and Mortality in Patients Undergoing Aortic and Mitral Valve Surgery: A Retrospective Study

This retrospective observational study aims to evaluate the effect of preoperative periodontal treatment on postoperative infection and mortality in patients undergoing aortic and mitral valve surgery.

Patient records between 2015 and 2024 analyzed. Demographic, clinical, and and radiographic findings, evaluated. Postoperative outcomes such as infection, antibiotic use, length of hospital and intensive care unit stay, and mortality assessed.

The findings of this study may contribute to understanding the role of periodontal health in improving postoperative outcomes in cardiac surgery patients.

Studie Overzicht

Toestand

Voltooid

Conditie

Gedetailleerde beschrijving

Periodontitis is a chronic inflammatory disease that has been associated with various systemic conditions, including cardiovascular diseases and infective endocarditis. Oral pathogens and inflammatory mediators originating from periodontal tissues may enter the bloodstream and contribute to systemic inflammation and postoperative complications.

This retrospective observational study includes patients aged 18 years and older who underwent aortic and mitral valve surgery and received or not periodontal treatment within 15 days prior to surgery. Patient records from 2015 to 2024 has been reviewed. Inclusion and exclusion criteria has been applied to ensure data consistency and reliability.

Collected data included demographic characteristics, medical history, periodontal disease stages, DMFT scores, and radiographic findings. Postoperative variables such as infection status, antibiotic use, duration of hospitalization, intensive care unit stay, and mortality has been evaluated.

Statistical analyses performed using appropriate parametric and non-parametric tests. Multivariate regression models used to identify factors associated with postoperative infection and mortality.

The aim of this study is to determine whether preoperative periodontal treatment has a significant impact on postoperative outcomes in patients undergoing cardiac valve surgery.

Studietype

Observationeel

Inschrijving (Werkelijk)

200

Contacten en locaties

In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.

Studie Locaties

  • Turkije (Türkiye)
    • Bakirköy
      • Istanbul, Bakirköy, Turkije (Türkiye), 34147
        • Bakirköy Dr. Sadi Konuk Education and Research Hospital

Deelname Criteria

Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.

Geschiktheidscriteria

Leeftijden die in aanmerking komen voor studie

  • Volwassen
  • Oudere volwassene

Accepteert gezonde vrijwilligers

Nee

Bemonsteringsmethode

Niet-waarschijnlijkheidssteekproef

Studie Bevolking

This retrospective study population consists of adult patients who underwent cardiac valve surgery and had available preoperative panoramic radiographs and complete clinical records. The study aims to evaluate the association between oral health status (DMFT index and radiographic periodontal condition) and postoperative clinical outcomes.

Beschrijving

Inclusion Criteria:

  • Adult patients (≥18 years) who underwent cardiac valve surgery
  • Availability of preoperative panoramic radiographs
  • Complete medical and dental records, including DMFT index and systemic clinical parameters
  • Patients with documented postoperative clinical follow-up data

Exclusion Criteria:

  • Patients under 18 years of age
  • Patients with incomplete or missing medical or radiographic records
  • Patients with a history of systemic conditions severely affecting bone metabolism (e.g., advanced malignancy, metabolic bone disease)
  • Patients who received recent periodontal treatment prior to radiographic assessment
  • Poor-quality radiographs that do not allow accurate evaluation

Studie plan

Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.

Hoe is de studie opgezet?

Ontwerpdetails

Cohorten en interventies

Groep / Cohort
Elective Surgery Patients
This cohort includes patients who underwent elective aortic or mitral valve surgery and had complete medical and dental records available. All patients received standard preoperative evaluation, and those with documented periodontal treatment within 15 days prior to surgery were included.
Emergency Surgery Patients
This cohort consists of patients who underwent emergency aortic or mitral valve surgery. Due to the urgent nature of the procedure, preoperative periodontal assessment and treatment not have been consistently performed.

Wat meet het onderzoek?

Primaire uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
Radiographic Alveolar Bone Loss Percentage Assessed on Panoramic Radiographs
Tijdsspanne: Preoperative assessment (baseline)
Radiographic periodontal bone loss have been assessed on panoramic radiographs by measuring the percentage of alveolar bone loss relative to root length. Bone loss severity will be categorized according to the extent of radiographic alveolar bone loss. Higher percentages indicate greater periodontal destruction and more severe periodontal disease.
Preoperative assessment (baseline)
Periodontal disease diagnosis (presence and severity)
Tijdsspanne: Preoperative assessment (baseline)
Periodontal disease diagnosed based on radiographic findings and classified according to established periodontal disease criteria (e.g., mild, moderate, or severe periodontitis).
Preoperative assessment (baseline)
DMFT index (Decayed, Missing, Filled Teeth score)
Tijdsspanne: Preoperative assessment (baseline)
The DMFT index calculated from radiographic and clinical records to quantify cumulative dental caries experience in each patient.
Preoperative assessment (baseline)
Postoperative infection-related clinical outcomes (fever duration)
Tijdsspanne: Measured within the first 7 postoperative days following cardiac surgery.
The number of days with postoperative fever (≥37.5°C) recorded from patient medical records and used as an indicator of postoperative infection.
Measured within the first 7 postoperative days following cardiac surgery.
Length of postoperative hospital stay (days)
Tijdsspanne: From the date of cardiac surgery until hospital discharge, assessed up to 30 days postoperatively.
The duration of hospitalization has been recorded in days from the date of cardiac surgery until hospital discharge and compared according to preoperative oral and periodontal status.
From the date of cardiac surgery until hospital discharge, assessed up to 30 days postoperatively.

Secundaire uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
Duration of intensive care unit (ICU) stay (days)
Tijdsspanne: From admission to the intensive care unit following cardiac surgery until ICU discharge, assessed up to 30 days postoperatively.
The number of days spent in the intensive care unit following cardiac surgery recorded and analyzed according to preoperative oral and periodontal health status.
From admission to the intensive care unit following cardiac surgery until ICU discharge, assessed up to 30 days postoperatively.
Time to initiation of oral feeding (days)
Tijdsspanne: From the date of cardiac surgery until initiation of oral feeding, assessed up to 30 days postoperatively.
The number of days from cardiac surgery to the initiation of oral feeding recorded and evaluated as an indicator of postoperative recovery.
From the date of cardiac surgery until initiation of oral feeding, assessed up to 30 days postoperatively.
Postoperative C-Reactive Protein (CRP) Level
Tijdsspanne: Measured within the first 7 postoperative days following cardiac surgery.
Serum C-reactive protein (CRP) concentration, measured in milligrams per liter (mg/L), obtained from medical records and analyzed as an indicator of postoperative systemic inflammatory response. Higher values indicate a greater inflammatory response.
Measured within the first 7 postoperative days following cardiac surgery.
Postoperative White Blood Cell (WBC) Count
Tijdsspanne: Measured within the first 7 postoperative days following cardiac surgery.
White blood cell count, measured in ×10⁹ cells/L, obtained from medical records and analyzed as an indicator of postoperative systemic inflammatory response. Higher values indicate a greater inflammatory response.
Measured within the first 7 postoperative days following cardiac surgery.

Medewerkers en onderzoekers

Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.

Sponsor

Istanbul University - Cerrahpasa

Publicaties en nuttige links

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Algemene publicaties

Studie record data

Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.

Bestudeer belangrijke data

Studie start (Werkelijk)

1 januari 2015

Primaire voltooiing (Werkelijk)

1 december 2024

Studie voltooiing (Werkelijk)

1 mei 2025

Studieregistratiedata

Eerst ingediend

19 mei 2026

Eerst ingediend dat voldeed aan de QC-criteria

31 mei 2026

Eerst geplaatst (Werkelijk)

4 juni 2026

Updates van studierecords

Laatste update geplaatst (Werkelijk)

4 juni 2026

Laatste update ingediend die voldeed aan QC-criteria

31 mei 2026

Laatst geverifieerd

1 mei 2026

Meer informatie

Termen gerelateerd aan deze studie

Trefwoorden

Aanvullende relevante MeSH-voorwaarden

Andere studie-ID-nummers

  • 2025/168

Plan Individuele Deelnemersgegevens (IPD)

Bent u van plan om gegevens van individuele deelnemers (IPD) te delen?

JA

Beschrijving IPD-plan

De-identified participant data including questionnaire responses and periodontal measurements will be available upon reasonable request after publication.

IPD delen Ondersteunend informatietype

  • LEERPROTOCOOL
  • ICF
  • ANALYTIC_CODE

Informatie over medicijnen en apparaten, studiedocumenten

Bestudeert een door de Amerikaanse FDA gereguleerd geneesmiddel

Nee

Bestudeert een door de Amerikaanse FDA gereguleerd apparaatproduct

Nee

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