Neurodevelopmental Rehabilitation for Toddlers With Complex Heart Defects
Visão geral do estudo
Status
Condições
Intervenção / Tratamento
Descrição detalhada
Neurodevelopmental deficits are a common morbidity among children who receive surgical treatment for complex congenital heart defects in infancy. Over 40% of children with complex heart defects will have neurodevelopmental deficits that persist throughout childhood even after a successful surgical procedure in infancy1. These deficits are typically related to basic motor perceptual motor or visual motor skills. Problems integrating what is seen (visual perceptions) with body movement (motor skills) makes it difficult for children to participate in peer play and limits their ability to succeed in school, thereby having a significant impact on the child's quality of life.
Traditional, therapist-delivered rehabilitation programmes to address these delays in neurodevelopment have not previously been attempted. It would be difficult to provide direct rehabilitation programmes to these patients given that their defects are rare and few patients are located within the same geographical area. Home-based, parent-delivered rehabilitation programmes have previously been shown to be effective at improving the motor skills of school-age children with complex heart defects5. Since a home-based parent delivered model would enable the participation of infants regardless of geographic location, the feasibility of using such a model for delivering neurodevelopmental rehabilitation should be investigated.
Tipo de estudo
Inscrição (Real)
Estágio
- Fase 2
Contactos e Locais
Locais de estudo
-
-
Ontario
-
Toronto, Ontario, Canadá, M5G 1X8
- The Hospital for Sick Children
-
-
Critérios de participação
Critérios de elegibilidade
Idades elegíveis para estudo
Aceita Voluntários Saudáveis
Gêneros Elegíveis para o Estudo
Descrição
Inclusion Criteria:
Families will be eligible to participate in this study if the child:
- Had the arterial switch operation (for transposition of the great arteries) or has had a Glenn procedure (for functional single ventricle).
- Is medically stable for normal infant activities.
- Is between 12 and 24 months of age in January 2010.
Exclusion Criteria:
Families will be excluded from study participation if:
- The child has a recognized syndrome or other disability affecting neurodevelopment.
- The child has had a medical procedure in the 3 months preceding the baseline study assessment.
- The cardiologist responsible for the child's care refuses to allow the child's participation.
- The child performs substantially above age-appropriate developmental milestones during the initial assessment (in which case an intervention is unlikely to have a detectable additional benefit).
Plano de estudo
Como o estudo é projetado?
Detalhes do projeto
- Finalidade Principal: Cuidados de suporte
- Alocação: N / D
- Modelo Intervencional: Atribuição de grupo único
- Mascaramento: Nenhum (rótulo aberto)
Armas e Intervenções
Grupo de Participantes / Braço |
Intervenção / Tratamento |
|---|---|
|
Experimental: All Subjects
A total of 20 children and their parents will be recruited for this study.
Ten children will have had the Glenn procedure and 10 infants will have had the arterial switch operation.
|
Participation in the study will require the parent and child to attend two assessment visits in addition to completing a series of parent and infant activities on a daily basis throughout the 10-week intervention period.
The parent-led activities will include activities such as walking with the child, stacking blocks, rolling a ball to the child, hiding a toy under a blanket for the child to find, encouraging the child to kick a rattle while the child is lying on his/her back, or crawling or rolling in different directions.
|
O que o estudo está medindo?
Medidas de resultados primários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
|
Change from baseline in child's neurodevelopmental status at four months using the Peabody Development Motor Scales
Prazo: Baseline and four months
|
The Peabody Development Motor Scale has demonstrated validity and reliability for children from birth to 5 years of age.
Six subtests (reflexes, stationary, locomotion, object manipulation, grasping, visual-motor integration) yield gross, fine and total motor quotient scores.
|
Baseline and four months
|
Medidas de resultados secundários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
|
Parents opinion on the home-based neurodevelopmental rehabilitation programme
Prazo: at 4 months
|
During the final assessment, the researcher will interview the parent to obtain their perspective on delivering the study activities at home.
|
at 4 months
|
|
Research students experience and perception of guiding a home-based, parent-delivered rehabilitation programme
Prazo: at 4 months
|
Research students participating in this project will also be interviewed regarding their experiences and perceptions of guiding a home-based, parent-delivered rehabilitation programme.
|
at 4 months
|
Colaboradores e Investigadores
Patrocinador
Investigadores
- Investigador principal: Brian McCrindle, MD, The Hospital for Sick Children, Toronto Canada
Datas de registro do estudo
Datas Principais do Estudo
Início do estudo
Conclusão Primária (Real)
Conclusão do estudo (Real)
Datas de inscrição no estudo
Enviado pela primeira vez
Enviado pela primeira vez que atendeu aos critérios de CQ
Primeira postagem (Estimativa)
Atualizações de registro de estudo
Última Atualização Postada (Estimativa)
Última atualização enviada que atendeu aos critérios de controle de qualidade
Última verificação
Mais Informações
Termos relacionados a este estudo
Palavras-chave
Outros números de identificação do estudo
- 1000014278
Essas informações foram obtidas diretamente do site clinicaltrials.gov sem nenhuma alteração. Se você tiver alguma solicitação para alterar, remover ou atualizar os detalhes do seu estudo, entre em contato com register@clinicaltrials.gov. Assim que uma alteração for implementada em clinicaltrials.gov, ela também será atualizada automaticamente em nosso site .
Ensaios clínicos em Defeitos Cardíacos
-
Region SkaneInscrevendo-se por conviteInsuficiência Cardíaca Classe II da New York Heart Association (NYHA) | Insuficiência Cardíaca Classe III da New York Heart Association (NYHA)Suécia
-
Medical University of BialystokMedical University of Lodz; Poznan University of Medical Sciences; Nicolaus Copernicus... e outros colaboradoresRescindidoInsuficiência Cardíaca Sistólica | Insuficiência Cardíaca com Fração de Ejeção Reduzida | Insuficiência Cardíaca Classe IV da New York Heart Association | Insuficiência Cardíaca Classe III da New York Heart AssociationPolônia
-
University of WashingtonAmerican Heart AssociationConcluídoInsuficiência Cardíaca, Congestiva | Alteração Mitocondrial | Insuficiência Cardíaca Classe IV da New York Heart AssociationEstados Unidos
-
Portuguese Association of Interventional CardiologyMedtronicRecrutamentoEstenose Aórtica Sintomática Grave (Definida como Classe ≥ II da New York Heart Association (NYHA))Portugal
Ensaios clínicos em Home-based neurodevelopmental rehabilitation programme
-
Healthy.io Ltd.ConcluídoDoenças agudas e crônicas detectáveis na urinaEstados Unidos
-
Healthy.io Ltd.ConcluídoDiabetes | Infecção do trato urinário | Falência renalEstados Unidos
-
Healthy.io Ltd.ConcluídoDoenças agudas e crônicas detectáveis na urinaEstados Unidos