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ICU Delirium: a One-week Snapshot of Burden Across the Eastern UK Region

17 июля 2013 г. обновлено: Papworth Hospital NHS Foundation Trust

ICU delirium negatively impacts on patient outcomes, as well as on resources and clinical workflow of the ICU. Effective healthcare resource planning requires reliable (i.e., multicentre) data that can inform on both of these.

The purpose of this study was to determine the impact of ICU delirium in terms of both patients and beds. The study was carried out prospectively, over a one-week period, at adult ICUs comprising the Norfolk, Suffolk, and Cambridgeshire Critical Care Network (NSC CCN).

Обзор исследования

Статус

Завершенный

Условия

Бред

Подробное описание

Previous delirium prevalence research has been carried out at single sites and yielded highly variable results (between 3-87%). Reliable multisite data can be obtained cost-effectively using a point-prevalence ("snapshot") approach.

Purpose: to obtain reliable data informing on prevalence of ICU delirium, in terms of both patients and beds, across the eastern UK region.

Design and Setting: this one-week observational prospective cohort study was carried out between June 25, 2012 (start of ICU day shift) to July 01, 2012 (end of night shift). Nine ICUs comprising the Norfolk, Suffolk, and Cambridgeshire Critical Care Network (NSC CCN) took part. Cambridgeshire 2 Research Ethics Committee approved the study (REC reference: 10/H0308/116) and waived the need for informed consent.

Patients and procedure: All adults treated over the study week at participating ICUs were considered eligible for inclusion. Delirium screening was carried out by patients' direct care clinicians using the Confusion Assessment Method for the ICU (CAM-ICU). All sites used this tool as part of their routine clinical practice and had delirium management guidelines in place at the time of the study. Patients who screened positive for delirium were treated according to local hospital practice.

Тип исследования

Наблюдательный

Регистрация (Действительный)

225

Контакты и местонахождение

В этом разделе приведены контактные данные лиц, проводящих исследование, и информация о том, где проводится это исследование.

Места учебы

Соединенное Королевство
- Cambridgeshire
  - Cambridge, Cambridgeshire, Соединенное Королевство, CB23 5EF
    - Papworth Hospital NHS Foundation Trust

Критерии участия

Исследователи ищут людей, которые соответствуют определенному описанию, называемому критериям приемлемости. Некоторыми примерами этих критериев являются общее состояние здоровья человека или предшествующее лечение.

Критерии приемлемости

Возраст, подходящий для обучения

18 лет и старше (Взрослый, Пожилой взрослый)

Принимает здоровых добровольцев

Нет

Полы, имеющие право на обучение

Все

Метод выборки

Вероятностная выборка

Исследуемая популяция

Adult critically ill patients across eastern UK region

Описание

Inclusion Criteria:

Adult patients treated within study time frame on Intensive Care Units across Norfolk, Suffolk, and Cambridgshire, UK

Exclusion Criteria:

Учебный план

В этом разделе представлена подробная информация о плане исследования, в том числе о том, как планируется исследование и что оно измеряет.

Как устроено исследование?

Детали дизайна

Количество групп / когорт

Когорты и вмешательства

Группа / когорта
Adult critically ill patients All adult patients treated within study time frame on Intensive Care Units across Norfolk, Suffolk, and Cambridgshire, UK

Что измеряет исследование?

Первичные показатели результатов

Мера результата	Мера Описание	Временное ограничение
Delirium prevalence Временное ограничение: June 25, 2012 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)	Number of patients with at least one recorded delirium-positive result, over total number of patients recorded over study time frame. Delirium screening will be carried out using the CAM-ICU by local direct care clinicians in accordance with region-wide clinical delirium-screening guidelines.	June 25, 2012 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)

Вторичные показатели результатов

Мера результата	Мера Описание	Временное ограничение
Proportion of patient-days with delirium Временное ограничение: June 25, 2012 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)	Number of patient-days with at least one recorded delirium-positive result over total patient-days recorded.	June 25, 2012 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)
Median delirium duration Временное ограничение: June 25, 2012 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)	In delirium patients: median number of days recorded with delirium over study time frame.	June 25, 2012 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)
Median days to transition to delirium Временное ограничение: June 25, 2012 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)	In delirium patients admitted during study time frame: median number of days from ICU admission to first recorded delirium day.	June 25, 2012 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)
Patient age, by delirium status Временное ограничение: June 25 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)	In delirium patients versus patients with no recorded delirium-positive result over study time frame: median age.	June 25 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)
Patient gender, by delirium status Временное ограничение: June 25 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)	In delirium patients versus patients with no recorded delirium-positive result over study time frame: number of males over total patients in each group.	June 25 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)
Admission type, by delirium status Временное ограничение: June 25 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)	In delirium patients versus patients with no recorded delirium-positive result over study time frame: number of (1) urgent/emergency and (2) elective admissions, over total patients in each group.	June 25 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)
Admission reason, by delirium status Временное ограничение: June 25 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)	In delirium patients versus patients with no recorded delirium-positive result over study time frame: number of (1) medical and (2) surgical admissions, over total patients in each group.	June 25 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)
Organ support, by delirium status Временное ограничение: June 25 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)	In delirium patients versus patients with no recorded delirium-positive result over study time frame: number receiving advanced and basic respiratory, advanced and basic cardiovascular, and renal support since ICU admission to end of study time frame, over total patients in each group.	June 25 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)
Mobilisation therapy, by delirium status Временное ограничение: June 25 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)	In delirium patients versus patients with no recorded delirium-positive result over study time frame: number receiving mobilisation therapy over study time frame, over total patients in each group.	June 25 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)
Median ICU days, by delirium status Временное ограничение: June 25 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)	In delirium patients versus patients with no recorded delirium-positive result over study time frame: median number of patient-days in ICU per patient, since admission to end of study time frame.	June 25 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)
Delirium screening compliance Временное ограничение: June 25 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)	Number of patient-days CAM-ICU administered (1) once or more and (2) twice or more, over total number of patient-days recorded over study time frame.	June 25 (start of ICU day shift) to July 1, 2012 (end of ICU night shift)

Соавторы и исследователи

Здесь вы найдете людей и организации, участвующие в этом исследовании.

Спонсор

Papworth Hospital NHS Foundation Trust

Соавторы

Norfolk, Suffolk, and Cambridgeshire Critical Care Network (NSC CCN)

Следователи

Главный следователь: Alain Vuylsteke, MD, Papworth Hospital NHS Foundation Trust

Даты записи исследования

Эти даты отслеживают ход отправки отчетов об исследованиях и сводных результатов на сайт ClinicalTrials.gov. Записи исследований и сообщаемые результаты проверяются Национальной медицинской библиотекой (NLM), чтобы убедиться, что они соответствуют определенным стандартам контроля качества, прежде чем публиковать их на общедоступном веб-сайте.

Изучение основных дат

Начало исследования

1 июня 2012 г.

Первичное завершение (Действительный)

1 июля 2012 г.

Завершение исследования (Действительный)