Safety and Pharmacokinetics Study of Redosing EXPAREL in Healthy Volunteers

Inclusion Criteria:

• Males or females ≥18 years of age.
• American Society of Anesthesiologists (ASA) physical status 1 or 2.
• Female subjects must be surgically sterile, at least 2 years postmenopausal, or using a medically acceptable method of birth control. If of childbearing potential, must have a documented negative pregnancy test within 24 hours before the first study drug administration.
• Able to provide informed consent, adhere to the study visit schedule, and complete all study assessments.

Exclusion Criteria:

• History of hypersensitivity or idiosyncratic reactions to amide-type local anesthetics.
• History of abnormal bleeding tendencies/clotting disorders.
• Regular use of anticoagulants (except for low dose aspirin for cardioprotection).
• Received any investigational drug within 30 days prior to study drug administration, and/or has planned administration of another investigational product or procedure during his/her participation in this study.
• Currently pregnant, nursing, or planning to become pregnant during the study or within 1 month after study drug administration.
• Subjects with significant medical conditions or laboratory results that, in the opinion of the Investigator, would constitute a contraindication to participation in the study, or cause inability to comply with the study requirements.
• Received bupivacaine or other local anesthetic within 7 days of first study drug administration.