Tackling Depression and Anxiety: A Working Memory Intervention
18 april 2014 uppdaterad av: Ingmar Franken, Erasmus Medical Center
Effects of Working Memory Training in a Depressed and Anxious Sample
Anxiety and depression are both associated with impairments in executive functions, including working memory (WM) which is needed to maintain and manipulate goal-relevant information.
Due to these WM impairments anxious and depressed individuals have difficulties inhibiting and shifting from irrelevant (negative) information and updating goal relevant information.
This study explored whether training WM decreases these impairments and reduces clinical symptoms and rumination.
Eighty-four individuals diagnosed with major depression and forty-nine individuals with an anxiety diagnosis executed WM or control tasks three times a week, during four weeks.
Before, after training and at a two months follow-up measurement depression and anxiety symptoms, WM capacity and rumination behaviour were assessed.
Training WM did only result in a reduction of anxiety symptoms in the depression group.
These findings are inconsistent with promising results of individual studies showing training WM result in an enlarged WM capacity and a decrease of psychopathological symptoms.
However, our results are in line with recent meta-analyses and reviews which show that WM training do not lead to generalized effects and therefore, doubt the clinical relevance of WM training programs.
Studieöversikt
Status
Avslutad
Betingelser
Intervention / Behandling
Studietyp
Interventionell
Inskrivning (Faktisk)
240
Fas
- Inte tillämpbar
Kontakter och platser
Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.
Studieorter
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Zuid Holland
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Rotterdam, Zuid Holland, Nederländerna, 3000 DR
- Erasmus University Rotterdam
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Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
16 år till 68 år (Barn, Vuxen, Äldre vuxen)
Tar emot friska volontärer
Nej
Kön som är behöriga för studier
Allt
Beskrivning
Inclusion Criteria:
- Major depression diagnosis
- Anxiety disorder diagnosis
Exclusion Criteria:
- Current psychosis
- Current substance dependency
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Behandling
- Tilldelning: Randomiserad
- Interventionsmodell: Parallellt uppdrag
- Maskning: Dubbel
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
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Experimentell: Arbetsminneträning
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The WM consisted of two tasks; the Number-letter task (Rogers & Monsell, 1995) and an Updating task.
The Number-letter task trains the ability to shift between task relevant stimuli.
Participants need to shift between four categories.
In the Updating task participants receive a set of three words in which they have to compare the two consecutive words on emotional valence (positive or negative) to train their updating skills.
Participants executed the training three times a week during four weeks.
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Placebo-jämförare: Placebo träning
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Both the WM and the placebo training consisted of two tasks; the Number-letter task (Rogers & Monsell, 1995) and an Updating task.
To prevent training WM the placebo training was a simplified version of the Number-letter task in which shifting was not required.
In the Updating task the placebo group only had to count the number of positive or negative words.
Participants executed the training three times a week during four weeks.
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Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
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Beck Depression Inventory Second Edition (BDI-II) score change between pre and post training and at follow-up measurement (2 months after post measurement)
Tidsram: Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)
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Depression is measured with the BDI-II
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Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)
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Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
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State-Trait Anxiety Inventory (STAI) scores change from pre to post training and to follow up measurement (2 months after post measurement)
Tidsram: Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)
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The STAI measures state, trait and total anxiety
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Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)
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Andra resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
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Ruminative Response Scale (RRS) score change between pre and post training and follow up (two months after post)
Tidsram: Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)
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The RRS measures rumination
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Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)
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Symmetry Span score change between pre and post training and at follow-up measurement (2 months after post measurement)
Tidsram: Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)
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The Symmetry Span measures working memory capacity
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Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)
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Internal shift task score change between pre and post training and at follow-up measurement (2 months after post measurement)
Tidsram: Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)
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The internal shift task measures working memory capacity
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Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)
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Samarbetspartners och utredare
Det är här du hittar personer och organisationer som är involverade i denna studie.
Sponsor
Utredare
- Huvudutredare: Elke Geraerts, PhD, Erasmus University Rotterdam
- Studierektor: Sabine Wanmaker, MSc, Erasmus University Rotterdam
Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart
1 april 2011
Primärt slutförande (Faktisk)
1 oktober 2011
Avslutad studie (Faktisk)
1 oktober 2011
Studieregistreringsdatum
Först inskickad
8 april 2014
Först inskickad som uppfyllde QC-kriterierna
18 april 2014
Första postat (Uppskatta)
22 april 2014
Uppdateringar av studier
Senaste uppdatering publicerad (Uppskatta)
22 april 2014
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
18 april 2014
Senast verifierad
1 april 2014
Mer information
Termer relaterade till denna studie
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- 1 (Mobile Health and Wellness Program)
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