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Dynamic Gait Analysis in Children With Mucopolysaccharidosis Type IVa

27 juli 2016 uppdaterad av: Saikat Santra, Birmingham Women's and Children's NHS Foundation Trust

Mucopolysaccharidosis Type IVa (MPS IVa, Morquio Disease) is a rare inherited lysosomal storage disorder caused by deficiency of the enzyme galactose-6-sulfatase.

Children with this disease accumulate a chemical called keratan sulphate, which stops their skeletons developing properly. They are very short in stature and many of their joints are unstable. Children with MPS IVa walk in a different way to other people due to a combination of lax ligaments and skeletal problems such as knock-knees.

Human walking involves the coordinated movements of all four limbs. As we walk, the arms swing oppositely to the legs. This movement pattern is very different in children with MPS IVa. This change seems to involve the whole musculoskeletal system and depends on the severity of the disease.

Recent studies in children with MPS IVa describing walking pattern have concentrated solely on the lower or upper limb respectively, and have not looked at the interaction of the upper and lower limbs during walking.

To our knowledge, the mechanics of walking in children with MPS IVa has not been investigated using a dynamic gait analysis tool (using cameras, sensors and electrodes to track the movements of different parts of the body during walking) and we aim to characterise this in a small number of children with MPS IVa and also examine the effects of splinting the wrist upon the walking pattern to see if this simple intervention makes it easier or more difficult for children with MPS IVa to walk.

Studieöversikt

Status

Indragen

Betingelser

Studietyp

Observationell

Kontakter och platser

Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.

Studieorter

  • Storbritannien
    • West Midlands
      • Birmingham, West Midlands, Storbritannien, B4 6NH
        • Birmingham Children's Hospital NHS Foundation Trust

Deltagandekriterier

Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.

Urvalskriterier

Åldrar som är berättigade till studier

6 år till 18 år (Barn, Vuxen)

Tar emot friska volontärer

Nej

Kön som är behöriga för studier

Allt

Testmetod

Icke-sannolikhetsprov

Studera befolkning

Children With Mucopolysaccharidosis Type IVa

Beskrivning

Inclusion Criteria:

  • Confirmed diagnosis of MPS IVa (documented history of reduced leucocyte GALNS enzyme activity relative to the normal range of the laboratory performing the assay AND/OR molecular analysis showing two pathogenic mutations in the GALNS gene)
  • Willing and able to provide written assent and parent/legal guardian able to provide written informed consent after the nature of the study has been explained and prior to any research-related procedures
  • Between 6 and 18 years of age inclusive
  • Willing to perform all study procedures as far as physically possible

Exclusion Criteria:

  • Inability to comply with Gait Analysis protocol (e.g. nonambulant)
  • Recent orthopaedic surgery that investigator deems might impact on Gait Analysis
  • Use of any investigational product or investigational medical device other than BMN110 within 30 days prior to recruitment, or requirement for any investigational agent other than BMN110 prior to completion of all scheduled study assessments
  • Concurrent disease or condition that would interfere with study participation or safety
  • Any condition that, in the view of the Principal or Subinvestigators, places the subject at high risk of not completing the study procedures

Studieplan

Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.

Hur är studien utformad?

Designdetaljer

Kohorter och interventioner

Grupp / Kohort
Children With Mucopolysaccharidosis Type IVa

Vad mäter studien?

Primära resultatmått

Resultatmått
Åtgärdsbeskrivning
Tidsram
Evidence of abnormal walking pattern and surface EMG activity as assessed by Dynamic Gait Analysis
Tidsram: Within 6 months of recruitment
Assessment of head, trunk and joint positions during walking using a 12 camera Vicon motion analysis system. Surface EMG analysis using a 16 channel wireless surface electromyographic (sEMG) system. Assessment of lower limb joint moments and powers using Kistler 9281 and AMTI OPT 400600 force plates.
Within 6 months of recruitment

Sekundära resultatmått

Resultatmått
Åtgärdsbeskrivning
Tidsram
Change in gait pattern over one year
Tidsram: 12 months after first analysis
Comparison of two gait analysis studies taken 12 months apart
12 months after first analysis
Effect on gait pattern of using wrist splints
Tidsram: Within 6 months of recruitment
Assessment of repeat gait analysis measurements done at first visit whilst wearing wrist splints
Within 6 months of recruitment
Effect on gait pattern of lower limb surgery
Tidsram: Within 3 and 6 months of any lower limb surgery
Further gait analysis studies will be done if a child undergoes any lower limb orthopaedic surgery during the study period and compared with pre-surgery analyses
Within 3 and 6 months of any lower limb surgery

Samarbetspartners och utredare

Det är här du hittar personer och organisationer som är involverade i denna studie.

Sponsor

Birmingham Women's and Children's NHS Foundation Trust

Samarbetspartners

BioMarin Pharmaceutical

Studieavstämningsdatum

Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.

Studera stora datum

Studiestart

1 juli 2016

Primärt slutförande (Faktisk)

1 juli 2016

Avslutad studie (Faktisk)

1 juli 2016

Studieregistreringsdatum

Först inskickad

28 maj 2014

Först inskickad som uppfyllde QC-kriterierna

29 maj 2014

Första postat (Uppskatta)

3 juni 2014

Uppdateringar av studier

Senaste uppdatering publicerad (Uppskatta)

28 juli 2016

Senaste inskickade uppdateringen som uppfyllde QC-kriterierna

27 juli 2016

Senast verifierad

1 juli 2016

Mer information

Termer relaterade till denna studie

Nyckelord

Ytterligare relevanta MeSH-villkor

Andra studie-ID-nummer

  • 14/WM/0120

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