Oxytocin's Effects on Real Time-fMRI Neurofeedback Training of Anterior Insula Activity
Effects of Intransal Oxytocin on Real-time fMRI Neurofeedback Training of Anterior Insula Activity Using an Interoceptive Strategy
Studieöversikt
Status
Betingelser
Intervention / Behandling
Detaljerad beskrivning
A randomized, double-blind, placebo-controlled between-subject design is employed in this study. A total of 80 healthy male participants are recruited and randomly assigned to two groups (oxytocin-OT vs. placebo-PLC). Participants self-administer either intranasal spray of oxytocin or placebo (24 IU). Both groups receive continuous real-time neurofeedback from the left anterior insula. Comparisons between the two groups are conducted to determine whether OT facilitates the neurofeedback effects.
The neurofeedback training task consists of 4 training sessions with real-time feedback and 1 transfer session without feedback. Each session comprises 5 regulation blocks and 5 rest blocks. At the end of each block, participants are presented with pain-related images and asked to rate their level of pain empathy, which was used to determine the effects of neurofeedback training at the behavioral level. A heartbeat detection task is performed pre- and post-training to measure interoceptive accuracy changes induced by neurofeedback training. A functional localizer task (heartbeat counting task) before training was used to localise the anterior insula. Neurofeedback training effects at the neural level were measured by anterior insula activity during training. Personality traits of subjects are assessed using validated Chinese version questionnaires, including the Toronto Alexithymia Scale (TAS), Multidimensional Assessment of Interoceptive Awareness (MAIA), Bermond-Vorst Alexithymia Questionnaire (BVAQ), Interoceptive Confusion Questionnaire (ICQ), Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), Autism Spectrum Quotient (ASQ), Interpersonal Reactivity Index (IRI), and Cognitive Flexibility Inventory (CFI). Participants are required to complete the Positive and Negative Affect Schedule (PANAS) once each before OT treatment, after OT treatment (before the neurofeedback training task), and after the neurofeedback training task to measure mood changes.
Studietyp
Inskrivning (Beräknad)
Fas
- Inte tillämpbar
Kontakter och platser
Studiekontakt
- Namn: Shuxia Yao, Dr
- Telefonnummer: 18111297596
- E-post: yaoshuxia@uestc.edu.cn
Studieorter
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Sichuan
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Chengdu, Sichuan, Kina, 611731
- Rekrytering
- University of Electronic Science and Technology of China
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Kontakt:
- Shuxia Yao, Dr
- Telefonnummer: 18111297596
- E-post: yaoshuxia@uestc.edu.cn
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-
Deltagandekriterier
Urvalskriterier
Åldrar som är berättigade till studier
- Vuxen
Tar emot friska volontärer
Beskrivning
Inclusion Criteria:
- Healthy subjects without any past or present psychiatric or neurological disorders.
Exclusion Criteria:
- History of brain injury medical or mental illness.
- Contraindication to MRI scanning (e.g., metal implants, claustrophobia or other --conditions that make them inappropriate for MRI scanning).
Studieplan
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Grundläggande vetenskap
- Tilldelning: Randomiserad
- Interventionsmodell: Parallellt uppdrag
- Maskning: Dubbel
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
|---|---|
|
Experimentell: Oxytocin
A single dose of 24 international units of oxytocin will be administered with 3 puffs of treatment to each nostril.
|
Each subject will be assigned to intranasally administered 24-IU of oxytocin.
|
|
Placebo-jämförare: Placebo
A single dose of 24 international units of placebo will be administered with 3 puffs of treatment to each nostril.
|
Each subject will be assigned to intranasally administered 24-IU of placebo.
|
Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Neural aktivitet i den främre insulan baserad på blodsyrenivåberoende (BOLD) signal
Tidsram: 1 timme
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Den främre insulans aktivitet som inducerades under regleringsblocket jämfört med baslinjeblocket.
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1 timme
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Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Interoceptiv noggrannhet
Tidsram: 10 minuter
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1/N Σ(1-(|faktiska hjärtslag--rapporterade hjärtslag|) / faktiska hjärtslag).
N anger antalet inspelningsblock.
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10 minuter
|
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Pain empathy rating scores
Tidsram: 1 hour
|
Subjects are required to rate their empathic feelings towards painful pictures on a Likert Scale ranging from 1-9 (1 = not at all and 9 = very painful) after each regulation/baseline block.
|
1 hour
|
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Confidence rating scores of interoceptive sensitivity
Tidsram: 1 hour
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Subjects are asked to rate to what extent they can feel their heartbeat using a Likert Scale ranging from 1-9 (1 = very low and 9 = very high).
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1 hour
|
|
Functional connectivity of the anterior insula
Tidsram: 1 hour
|
Differences of functional connectivity of the anterior insula during neurofeedback training
|
1 hour
|
Samarbetspartners och utredare
Studieavstämningsdatum
Studera stora datum
Studiestart (Beräknad)
Primärt slutförande (Beräknad)
Avslutad studie (Beräknad)
Studieregistreringsdatum
Först inskickad
Först inskickad som uppfyllde QC-kriterierna
Första postat (Faktisk)
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
Senast verifierad
Mer information
Termer relaterade till denna studie
Andra studie-ID-nummer
- UESTC-neuSCAN-108
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