Prevalence and Risk Factors for Chronic Post-Surgical Pain Following Video-Assisted Thoracic Surgery : The EVATHO Prospective Bicentric Cohort Study. (EVATHO)
29 juni 2026 uppdaterad av: University Hospital, Montpellier
Study of the Prevalence of Chronic Postoperative Pain After Video-Assisted Thoracic Surgery: A Bicentric Cohort Study
Chronic post-surgical pain (CPSP) remains a common complication after thoracic surgery and may significantly impair patients' quality of life. Although the widespread adoption of video-assisted thoracic surgery (VATS) has reduced surgical trauma and improved postoperative recovery, a substantial proportion of patients still develop persistent pain.
The EVATHO study is a multicenter prospective observational cohort designed to determine the prevalence of CPSP three months after VATS and to identify perioperative factors associated with its development. Adult patients undergoing thoracic surgery by VATS at Montpellier and Nice University Hospitals will be prospectively enrolled.
Pain intensity, neuropathic pain characteristics, anxiety, depression, quality of life, and analgesic consumption will be assessed using validated questionnaires during the perioperative period and at 1 and 3 months after surgery. The results of this study may help identify patients at increased risk of CPSP and improve perioperative pain management strategies following thoracic surgery.
Studieöversikt
Status
Har inte rekryterat ännu
Studietyp
Observationell
Inskrivning (Beräknad)
400
Kontakter och platser
Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.
Studiekontakt
- Namn: Benjamin Bourdois, MD
- Telefonnummer: +33467335958
- E-post: b-bourdois@chu-montpellier.fr
Studera Kontakt Backup
- Namn: Sophie Bringuier, MD
- Telefonnummer: +33467335958
Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
- Vuxen
- Äldre vuxen
Tar emot friska volontärer
Ja
Testmetod
Icke-sannolikhetsprov
Studera befolkning
Adult patients undergoing video-assisted thoracic surgery (VATS) for pulmonary resection, pleural procedures, chest wall surgery, or lung biopsy at Montpellier and Nice University Hospitals.
Beskrivning
Inclusion Criteria:
- Adult patients undergoing video-assisted thoracic surgery (VATS) for thoracic surgery
Exclusion Criteria:
- Age <18 years
- Adults under legal protection or unable to provide informed non-opposition
- Patients unable to understand or complete the study questionnaires
- Patients not affiliated with a French health insurance scheme.
- Adults under legal protection, including judicial safeguard, guardianship, or curatorship.
- Participation in another clinical study involving an ongoing exclusion period.
- Pregnant or breastfeeding women.
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Number of participants with chronic post-surgical pain
Tidsram: 3 months after surgery.
|
Chronic post-surgical pain defined as a Brief Pain Inventory (BPI) average pain score greater than 3 at the 3-month postoperative follow-up.
|
3 months after surgery.
|
Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Postoperative pain at 1 month after VATS
Tidsram: 1 month after thoracic surgery
|
Post-surgical pain defined as a Brief Pain Inventory (BPI) average pain score greater than 3 at the 1-month postoperative follow-up.
|
1 month after thoracic surgery
|
|
Visual Analogue Scale (VAS) pain score
Tidsram: Preoperative assessment, postoperative day 1, postoperative day 2, 1 month, and 3 months after surgery.
|
Pain intensity measured using the Visual Analogue Scale (VAS), with scores ranging from 0 (no pain) to 10 (worst imaginable pain).
|
Preoperative assessment, postoperative day 1, postoperative day 2, 1 month, and 3 months after surgery.
|
|
Cumulative postoperative opioid consumption.
Tidsram: Postoperative day 1, postoperative day 2, 1 month, and 3 months after surgery.
|
Total opioid consumption during the postoperative period as morphine milligram equivalents
|
Postoperative day 1, postoperative day 2, 1 month, and 3 months after surgery.
|
|
Douleur Neuropathie 4 (DN4) score
Tidsram: Preoperative assessment, postoperative day 1, postoperative day 2, 1 month, and 3 months after surgery.
|
Neuropathic pain measured using the Douleur Neuropathique 4 (DN4) questionnaire.
Scores range from 0 to 10, with scores greater than or equal to 4 indicating neuropathic pain.
|
Preoperative assessment, postoperative day 1, postoperative day 2, 1 month, and 3 months after surgery.
|
|
Hospitalier Anxiety and depression Scale (HADS) anxiety score
Tidsram: Preoperative assessment, 1 month, and 3 months after surgery.
|
Anxiety measured using the hospital Anxiety and Depression Scale (HADS-A).
Scores range from 0 to 21, with scores greater than or equal to 11 indicating clinically significant anxiety.
|
Preoperative assessment, 1 month, and 3 months after surgery.
|
|
Hospital Anxiety and Depression Scale (HADS) depression score
Tidsram: Preoperative assessment, 1 month, and 3 months after surgery
|
Depression measured using the Hospital Anxiety and Depression Scale (HADS-D).
Scores range from 0 to 21, with scores greater than or equal to 11 indicating clinically significant depression.
|
Preoperative assessment, 1 month, and 3 months after surgery
|
|
Brief Pain Inventory (BPI) pain interference score
Tidsram: 1 month and 3 months after surgery.
|
Pain interference with daily activities measured using the Brief Pain Inventory (BPI) interference subscale
|
1 month and 3 months after surgery.
|
|
Short Form-12 Physical component summary score
Tidsram: Preoperative assessment, 1 month, and 3 months after surgery.
|
Physical health-related quality of life measured using the Physical Component Summary (PCS) score of the Short Form-12 (SF-12) questionnaire.
|
Preoperative assessment, 1 month, and 3 months after surgery.
|
|
Short form-12 Mental Component Summary score
Tidsram: Preoperative assessment, 1 month and 3 months after surgery
|
Mental health-related quality of life measured using the Mental Component Summary (MCS) score of the Short Form-12 (SF-12) questionnaire.
|
Preoperative assessment, 1 month and 3 months after surgery
|
Samarbetspartners och utredare
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Sponsor
Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart (Beräknad)
1 augusti 2026
Primärt slutförande (Beräknad)
1 april 2028
Avslutad studie (Beräknad)
1 augusti 2028
Studieregistreringsdatum
Först inskickad
21 juni 2026
Först inskickad som uppfyllde QC-kriterierna
29 juni 2026
Första postat (Faktisk)
7 juli 2026
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
7 juli 2026
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
29 juni 2026
Senast verifierad
1 juni 2026
Mer information
Termer relaterade till denna studie
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- RECHMPL 25_0555
Plan för individuella deltagardata (IPD)
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NEJ
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Nej
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