DNA Array Analysis of Patients With Cervical Cancer
A Pilot Study of Early Changes in DNA Array Expression Following Chemo-Radiation Treatment of Cervical Cancer
研究概览
详细说明
Patients in this study are already scheduled to begin radiation therapy. Researchers will get tumor cells by taking two biopsies of the cervix. The first biopsy of the cervical tumor will be done before any treatment is given. The second biopsy will be performed about 48 hours after the radiation treatment has begun. They will then study the cells in the lab with a new technique for studying gene expression called DNA array, as well as human papillomavirus (HPV) analysis, quantification of apoptosis levels, hematoxylin and eosin staining, and storage of tissue for future research.
The patterns of gene expression in the biopsies will be compared with the success of radiation treatments.
Some of the material will also be stored and used in the future for other research projects.
This is an investigational study. A total of 18 patients will take part in this study. All will be enrolled at UTMDACC.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Texas
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Houston、Texas、美国、77030
- University of Texas MD Anderson Cancer Center
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参与标准
资格标准
适合学习的年龄
- 孩子
- 成人
- 年长者
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Newly diagnosed cervical cancer: clinical Stage IB -IIIB
- Invasive pure squamous cell carcinoma
- Planned treatment with concurrent cisplatinum/5-fluorouracil chemotherapy and pelvic radiation
Exclusion Criteria:
1. Previous cervical cancer treatment including but not limited to transvaginal cone irradiation
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
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Cervical cancer tumor biopsy + radiation therapy
Cervical cancer tumor biopsy + radiation therapy.
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Biopsies of the cervical tumor performed first before any treatment is given, and the second about 48 hours after radiation treatment has began.
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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The goal of this clinical research study is to find out if the expression of certain genes is linked with the response of cervical cancer to radiation.
大体时间：8 Years
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8 Years
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次要结果测量
结果测量 |
大体时间 |
|---|---|
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Researchers will study a large number of genes located in tumor material to learn this information.
大体时间：8 Years
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8 Years
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合作者和调查者
出版物和有用的链接
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.