Neurovascular Coupling in Patients With Open Angle Glaucoma
A variety of studies demonstrate that ocular blood flow is altered in glaucoma. Various animal and human studies have shown an increase in retinal and optic nerve head blood flow in response to diffuse luminance flicker. Based on studies with ERG, this effect has been attributed to augmented activity in the retinal ganglion cells and associated axons indicating a coupling mechanism between neuronal activity and retinal blood flow. Whereas a variety of studies have confirmed these effects, the knowledge about this coupling in the retina of patients with glaucoma is sparse.
Recently the investigators could show that flicker induced vasodilatation is blunted in patients with open angle glaucoma. However, the investigators results are limited by the fact that only data about retinal vessel diameters, not blood flow per se, are available. The further development of the investigators current flicker stimulation technique now allows us to determine blood flow velocity during flicker stimulation. Thus, in the current study, the investigators set out to determine whether this blood flow response is impaired in patients with glaucoma as compared to those in healthy volunteers and whether this is related to altered neural activity.
The study objective was, to investigate whether the blood flow response to flicker stimulation is altered in patients with glaucoma.
研究概览
研究类型
注册 (预期的)
联系人和位置
学习地点
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Vienna、奥地利、1090
- Department of Clinical Pharmacology, Meical University of Vienna, Austria
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Men and women aged between 20 and 80 years.
- Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant.
- Inclusion criteria of patients are open angle glaucoma.
- Men and women will be included in equal parts. A pregnancy test will be performed at screening.
- Ametropia of less than 3 diopters and anisometropia of less than 1 diopter.
Exclusion Criteria:
- Treatment with vasoactive drugs.
- Presence of intraocular pathology other than open angle glaucoma.
- Presence of ocular hypertension or PEX (pseudoexfoliation) glaucoma
- History or family history of epilepsy.
- Pregnancy.
- Diabetes mellitus.
学习计划
研究是如何设计的？
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
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a
15 male and 15 female patients with glaucoma
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non-invasive haemodynamic measurements of retinal vessel diameters, laser Doppler flowmetry and laser Doppler velocimetry
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b
30 sex matched healthy volunteers
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non-invasive haemodynamic measurements of retinal vessel diameters, laser Doppler flowmetry and laser Doppler velocimetry
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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Retinal blood velocity (laser Doppler velocimetry)
大体时间：measurements done only once on the studyday
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measurements done only once on the studyday
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Retinal arterial and venous diameter (Retinal vessel analyzer)
大体时间：measurements done only once on the studyday
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measurements done only once on the studyday
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Optic nerve head blood flow (laser Doppler flowmetry)
大体时间：measurements done only once on the studyday
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measurements done only once on the studyday
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Latency and amplitude (pattern ERG)
大体时间：measurements done only once on the studyday
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measurements done only once on the studyday
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次要结果测量
结果测量 |
大体时间 |
|---|---|
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Mean arterial pressure
大体时间：measurements done only once on the studyday
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measurements done only once on the studyday
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合作者和调查者
调查人员
- 首席研究员：Gabriele Fuchsjäger Mayrl, MD、Department of Clinical Pharmacology, Meical University of Vienna
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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