Neurovascular Coupling in Patients With Open Angle Glaucoma
A variety of studies demonstrate that ocular blood flow is altered in glaucoma. Various animal and human studies have shown an increase in retinal and optic nerve head blood flow in response to diffuse luminance flicker. Based on studies with ERG, this effect has been attributed to augmented activity in the retinal ganglion cells and associated axons indicating a coupling mechanism between neuronal activity and retinal blood flow. Whereas a variety of studies have confirmed these effects, the knowledge about this coupling in the retina of patients with glaucoma is sparse.
Recently the investigators could show that flicker induced vasodilatation is blunted in patients with open angle glaucoma. However, the investigators results are limited by the fact that only data about retinal vessel diameters, not blood flow per se, are available. The further development of the investigators current flicker stimulation technique now allows us to determine blood flow velocity during flicker stimulation. Thus, in the current study, the investigators set out to determine whether this blood flow response is impaired in patients with glaucoma as compared to those in healthy volunteers and whether this is related to altered neural activity.
The study objective was, to investigate whether the blood flow response to flicker stimulation is altered in patients with glaucoma.
調査の概要
研究の種類
入学 (予想される)
連絡先と場所
研究場所
-
-
-
Vienna、オーストリア、1090
- Department of Clinical Pharmacology, Meical University of Vienna, Austria
-
-
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Men and women aged between 20 and 80 years.
- Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant.
- Inclusion criteria of patients are open angle glaucoma.
- Men and women will be included in equal parts. A pregnancy test will be performed at screening.
- Ametropia of less than 3 diopters and anisometropia of less than 1 diopter.
Exclusion Criteria:
- Treatment with vasoactive drugs.
- Presence of intraocular pathology other than open angle glaucoma.
- Presence of ocular hypertension or PEX (pseudoexfoliation) glaucoma
- History or family history of epilepsy.
- Pregnancy.
- Diabetes mellitus.
研究計画
研究はどのように設計されていますか？
コホートと介入
グループ/コホート |
介入・治療 |
|---|---|
|
a
15 male and 15 female patients with glaucoma
|
non-invasive haemodynamic measurements of retinal vessel diameters, laser Doppler flowmetry and laser Doppler velocimetry
|
|
b
30 sex matched healthy volunteers
|
non-invasive haemodynamic measurements of retinal vessel diameters, laser Doppler flowmetry and laser Doppler velocimetry
|
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
時間枠 |
|---|---|
|
Retinal blood velocity (laser Doppler velocimetry)
時間枠：measurements done only once on the studyday
|
measurements done only once on the studyday
|
|
Retinal arterial and venous diameter (Retinal vessel analyzer)
時間枠：measurements done only once on the studyday
|
measurements done only once on the studyday
|
|
Optic nerve head blood flow (laser Doppler flowmetry)
時間枠：measurements done only once on the studyday
|
measurements done only once on the studyday
|
|
Latency and amplitude (pattern ERG)
時間枠：measurements done only once on the studyday
|
measurements done only once on the studyday
|
二次結果の測定
結果測定 |
時間枠 |
|---|---|
|
Mean arterial pressure
時間枠：measurements done only once on the studyday
|
measurements done only once on the studyday
|
協力者と研究者
捜査官
- 主任研究者：Gabriele Fuchsjäger Mayrl, MD、Department of Clinical Pharmacology, Meical University of Vienna
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。