The Feasibility of Dexmedetomidine for Awake Fiberoptic Nasal Intubation
Interventional Study of Dexmedetomidine for Sedating Anticipated Difficult Airway Patients Undergoing Awake Fiberoptic Nasal Intubation
研究概览
详细说明
Case number: 60, ASA I-III oral cancer patients with limited mouth opening
Patients will be randomly allocated into three groups, Dex group received dexmedetomidine (1.0 mcg/kg) infusion, Control group received saline, and Propofol group received 1% Propofol administrated usng effect-site TCI.
Main outcome was evaluated by grading scores presenting conditions for nasal intubation, post-intubation and satisfaction.
Other analysed parameters included airway obstruction, hemodynamic changes, treatment for hemodynamics response, consumption time for intubation, amnesia level, and postoperative adverse events. All outcome measurements were classified by scoring systems.
研究类型
注册 (预期的)
阶段
- 阶段2
- 第三阶段
联系人和位置
学习地点
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Kaohsiung、台湾、807
- 招聘中
- Kaohsiung Medical University Chung-Ho Hospital
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接触：
- Koung-Shing Chu, Master
- 电话号码：7035 886-7-3121101
- 邮箱：cks0708@ms.kmuh.org.tw
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Head and neck cancer patients with limited mouth opening
- Undergoing awake fiberoptic nasal intubation for elective surgery
Exclusion Criteria:
- a history of severe bradycardia
- any type of A-V block in EKG
- heart failure
- liver cirrhosis
- thrombocytopenia
- coagulopathy
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：单组作业
- 屏蔽：四人间
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：1 dex group
received dexmedetomidine (1.0 mcg/kg) infusion
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dexmedetomidine 1.0 mcg/kg infusion for 10minutes
其他名称：
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安慰剂比较：2 control group
received 0.9% saline
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0.9% Normal Saline 0.25ml/kg infusion for 10minues
其他名称：
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有源比较器：3 Propofol group
received 1% propofol using effect-site TCI(Base Primea, Fresenius, France)
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Propofol: The initial target = 3 μg/ml. The TCI is adjusted by 0.5μg/ml according to patient comfort during the procedure. The Orchestra® Base Primea(Fresenius, Brezins, France) offers a Target Controlled Infusion (TCI) target controlled infusion.
其他名称：
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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grading scores presenting conditions for nasal intubation
大体时间：before and after intubation
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before and after intubation
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合作者和调查者
调查人员
- 研究主任：Koung-Shing Chu, Master、Kaohsiung Medical University
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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