Study of Bone Disease in Older HIV-infected Adults
A Pilot Study on the Immunopathogenesis of Bone Disease in Older HIV-infected Adults
This study will look to see if there are changes in the blood cells that are associated with bone disease and sort out effects that are due to the HIV virus itself, the medications and see if faster aging occurs in the cells of HIV infected persons. Bone disease will be measured by a special X-ray called a DEXA scan. A DEXA scan is used by doctors to see if someone has normal bone mass for their age or if there is thinning of the bones.
The purposes of this study are:
- to learn how common bone disease is in HIV infected patients over the age of 50 years that receive their care at the CORE Center
- to see what are the common causes of bone disease in older HIV infected persons
- to see if there are differences in blood cells and levels of cytokines in patients who do or do not have bone disease, as this may help researchers determine the cause of bone disease.
研究概览
研究类型
注册 (实际的)
联系人和位置
学习地点
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Illinois
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Chicago、Illinois、美国、60612
- Ruth M Rothstein CORE Center
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
100 HIV-infected adults, age 50 years or older, on HAART with undetectable viral loads, who are randomly sampled from 6 strata defined by ethnicity (Black:White:Hispanic; 2:1:1) and sex (male:female; 1:1).
100 HIV+ adults, age ≥ 50 yr (50 ♂, 50 ♀; 50 AA, 25 W, 25 H).
描述
Inclusion Criteria:
- HIV-1 infection documented by ELISA and confirmed by western blot
- Treatment with antiretroviral drugs for at least 12 months
- Age 50-70 years
- CD4 count > 350 cells/mm3 for at least 6 months
- HIV-RNA undetectable (< 75 copies/ml for at least 6 months)
Exclusion Criteria:
- Known bone disease (primary or metastatic malignancy, osteomalacia)
- Treatment for bone disease (bisphosphonates, calcitonin, strontium, sodium fluoride, synthetic PTH, or high-dose vitamin D [> 800 IU daily]).
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
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HIV older than 50 years
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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Assess the associations between outcome (bone density) and predictors (markers of inflammation and immune activation) using continuous variables
大体时间：6 months
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6 months
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合作者和调查者
调查人员
- 首席研究员：Oluwatoyin Adeyemi, MD、Ruth M. Rothstein CORE Center
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.