Upper Airways in Pregnancy: Evaluation by the Acoustic Reflection Method (MAVAG)
It is well known that airway management can be difficult during pregnancy. Increased risks for difficult intubation in pregnant women have been often reported. Thus, pregnancy is regarded as a period of high anesthesiologic risk.
Generalized weight gain is a well known factor influencing the upper airway in pregnant women. However, the modifications of the airway itself are less well documented.
The acoustic reflection method is based on the analysis of the reflection of a single transient planar wave allowing the analysis of the longitudinal cross-sectional area profile of the examined cavity. It is a noninvasive and harmless method.
The aim of the study is to evaluate by acoustic reflection method the physiological modifications of the upper airways during pregnancy.
Women enrolled in the study will undergo an acoustic recording during the first, second, and third trimester of pregnancy, as well as two days and one month after delivery. Forty pregnant women will be included in this monocentric, prospective, open labelled study.
Moreover, a single acoustic recording will be performed in 10 other pregnant women undergoing an MRI for obstetrical purpose. The estimated caliber of the upper airways by MRI and acoustic method will be compared.
研究概览
研究类型
注册 (实际的)
联系人和位置
学习地点
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Paris、法国、75012
- Hôpîtal d'Enfants Armand Trousseau
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Paris、法国、75012
- Armand Trousseau University Hospital
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Pregnant women who attend the routine ultrasound control in our institution before 14 weeks of pregnancy will be invited to participate in the study.
Women are eligible for the study if they are:
- healthy (no previous disease, hypertension, nor obesity),
- 18 years or more
- with a singleton live fetus at the routine ultrasound scan
- with a normal pregnancy.
Exclusion Criteria:
- Pregnancy complications
- Multiple pregnancy
- High risk for preterm labor
- Underlying diseases that could interfere with the results (such as pre-existing upper airway problems) and participation.
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
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Physiological modifications
Pregnant women who attend the routine ultrasound control in our institution before 14 weeks of pregnancy
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An acoustic reflection device gives the longitudinal cross-sectional area profile along airways.
It is based on the analysis of a planar acoustic wave propagating in a rigid duct connected to airway.
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MRI and acoustic
Women undergoing an MRI for obstetrical purpose
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An acoustic reflection device gives the longitudinal cross-sectional area profile along airways.
It is based on the analysis of a planar acoustic wave propagating in a rigid duct connected to airway.
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Physiological modifications during pregnancy and acoustic reflection method
大体时间:6 months
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Main aim: to evaluate by acoustic reflection method the physiological modifications of the upper airways during pregnancy. Women enrolled in the study will undergo an acoustic recording during:
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6 months
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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MRI and acoustic reflection method
大体时间:6 months
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Secondary aim: a single acoustic recording will be proposed to 10 pregnant women undergoing an MRI for obstetrical purpose. The estimated caliber of the upper airways by MRI and acoustic method will be compared. |
6 months
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合作者和调查者
调查人员
- 研究主任:Brigitte Fauroux, MD, PhD、Assistance Publique - Hôpitaux de Paris
- 首席研究员:Nicolas LEBOULANGER, MD、Assistance Publique - Hôpitaux de Paris
出版物和有用的链接
一般刊物
- Kodali BS, Chandrasekhar S, Bulich LN, Topulos GP, Datta S. Airway changes during labor and delivery. Anesthesiology. 2008 Mar;108(3):357-62. doi: 10.1097/ALN.0b013e31816452d3.
- Louis B, Fodil R, Jaber S, Pigeot J, Jarreau PH, Lofaso F, Isabey D. Dual assessment of airway area profile and respiratory input impedance from a single transient wave. J Appl Physiol (1985). 2001 Feb;90(2):630-7. doi: 10.1152/jappl.2001.90.2.630.
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- MAVAG
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