Upper Airways in Pregnancy: Evaluation by the Acoustic Reflection Method (MAVAG)
It is well known that airway management can be difficult during pregnancy. Increased risks for difficult intubation in pregnant women have been often reported. Thus, pregnancy is regarded as a period of high anesthesiologic risk.
Generalized weight gain is a well known factor influencing the upper airway in pregnant women. However, the modifications of the airway itself are less well documented.
The acoustic reflection method is based on the analysis of the reflection of a single transient planar wave allowing the analysis of the longitudinal cross-sectional area profile of the examined cavity. It is a noninvasive and harmless method.
The aim of the study is to evaluate by acoustic reflection method the physiological modifications of the upper airways during pregnancy.
Women enrolled in the study will undergo an acoustic recording during the first, second, and third trimester of pregnancy, as well as two days and one month after delivery. Forty pregnant women will be included in this monocentric, prospective, open labelled study.
Moreover, a single acoustic recording will be performed in 10 other pregnant women undergoing an MRI for obstetrical purpose. The estimated caliber of the upper airways by MRI and acoustic method will be compared.
Studieoversigt
Undersøgelsestype
Tilmelding (Faktiske)
Kontakter og lokationer
Studiesteder
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Paris, Frankrig, 75012
- Hôpîtal d'Enfants Armand Trousseau
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Paris, Frankrig, 75012
- Armand Trousseau University Hospital
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Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Prøveudtagningsmetode
Studiebefolkning
Beskrivelse
Inclusion Criteria:
- Pregnant women who attend the routine ultrasound control in our institution before 14 weeks of pregnancy will be invited to participate in the study.
Women are eligible for the study if they are:
- healthy (no previous disease, hypertension, nor obesity),
- 18 years or more
- with a singleton live fetus at the routine ultrasound scan
- with a normal pregnancy.
Exclusion Criteria:
- Pregnancy complications
- Multiple pregnancy
- High risk for preterm labor
- Underlying diseases that could interfere with the results (such as pre-existing upper airway problems) and participation.
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Kohorter og interventioner
Gruppe / kohorte |
Intervention / Behandling |
|---|---|
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Physiological modifications
Pregnant women who attend the routine ultrasound control in our institution before 14 weeks of pregnancy
|
An acoustic reflection device gives the longitudinal cross-sectional area profile along airways.
It is based on the analysis of a planar acoustic wave propagating in a rigid duct connected to airway.
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MRI and acoustic
Women undergoing an MRI for obstetrical purpose
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An acoustic reflection device gives the longitudinal cross-sectional area profile along airways.
It is based on the analysis of a planar acoustic wave propagating in a rigid duct connected to airway.
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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Physiological modifications during pregnancy and acoustic reflection method
Tidsramme: 6 months
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Main aim: to evaluate by acoustic reflection method the physiological modifications of the upper airways during pregnancy. Women enrolled in the study will undergo an acoustic recording during:
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6 months
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Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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MRI and acoustic reflection method
Tidsramme: 6 months
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Secondary aim: a single acoustic recording will be proposed to 10 pregnant women undergoing an MRI for obstetrical purpose. The estimated caliber of the upper airways by MRI and acoustic method will be compared. |
6 months
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Samarbejdspartnere og efterforskere
Samarbejdspartnere
Efterforskere
- Studieleder: Brigitte Fauroux, MD, PhD, Assistance Publique - Hopitaux de Paris
- Ledende efterforsker: Nicolas LEBOULANGER, MD, Assistance Publique - Hopitaux de Paris
Publikationer og nyttige links
Generelle publikationer
- Kodali BS, Chandrasekhar S, Bulich LN, Topulos GP, Datta S. Airway changes during labor and delivery. Anesthesiology. 2008 Mar;108(3):357-62. doi: 10.1097/ALN.0b013e31816452d3.
- Louis B, Fodil R, Jaber S, Pigeot J, Jarreau PH, Lofaso F, Isabey D. Dual assessment of airway area profile and respiratory input impedance from a single transient wave. J Appl Physiol (1985). 2001 Feb;90(2):630-7. doi: 10.1152/jappl.2001.90.2.630.
Datoer for undersøgelser
Studer store datoer
Studiestart
Primær færdiggørelse (Faktiske)
Studieafslutning (Faktiske)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Skøn)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Andre undersøgelses-id-numre
- MAVAG
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