Procedures of Locoregional Analgesia and Quality of Life in Palliative Care Units (TALViSoP)
Procedures of Locoregional Analgesia and Quality of Life in Palliative Care
Number of patients in mobile palliative care units have pain of both nociceptive and neuropathic origin. In certain cases, procedures of locoregional analgesia can be helpful.
The Purpose of this study is to evaluate the impact of techniques of locoregional analgesia in a palliative population
研究概览
详细说明
Cancer pain is a serious problem in the palliative population. In particular, pain due to compression or invasion of nerve tissue by metastasis is frequent and often unresponsive to oral drug therapy and even to epidural administration of opioids. In such refractory pain in a palliative setting, one modality that could be helpful is the use of technics of locoregional analgesia. Currently, they are routinely used for the management of acute postoperative pain and become to be more widely used for cancer surgery. For example, intrapleural intercostal nerve blocks after major lung resection or preincisional paravertebral blocks after breast surgery have been shown to improve pain control. However, locoregional analgesia is only occasionally used in chronic cancer pain.
The procedures used are epidural analgesia, rachianesthesia, or continuous nerve blocks. L-bupivacaine will be used. The procedure will be performed only if the injection test is positive.
The patients will be evaluated before and after the procedure, the patient being his/her own control. Evaluations will take place immediately before the procedure, then at 48 hours, 1 week and 1 month after the procedure.
研究类型
注册 (预期的)
阶段
- 不适用
联系人和位置
学习地点
-
-
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Bordeaux、法国
- Centre Hospitalier Universitaire - Hôpital Saint André
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Châteauroux、法国
- Centre Hospitalier de Chateauroux
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Guéret、法国
- Centre Hospitalier de Guéret
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Liomges、法国
- CHU Limoges
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Saint Leonard de Noblat、法国
- Centre Hospitalier Local
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Tulle、法国
- Centre Hospitalier de Tulle
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-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Patient ≥ 18 years-old, male or female, whatever his/her ethnic group
- Patient with untreatable cancer
- Patient hospitalized in a palliative care unit, with a life expectancy ≥ 1 week
- Pain unresponsive to conventional treatments
- Effectiveness of the injection test
- Signed informed consent
Exclusion Criteria:
- Patients > 18 years-old
- Patients with pain other than cancer pain
- Patient's refusal
- Coagulation disorders
- Local infection
- Known hypersensitivity to local analgesics
- Inefficacy of the injection test.
- Contraindication for analgesics
学习计划
研究是如何设计的？
设计细节
- 主要用途：支持治疗
- 分配：不适用
- 介入模型：单组作业
- 屏蔽：无（打开标签）
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Change in patients global quality of life
大体时间：1 week after first injection
|
To evaluate the change in patients global quality of life, assessed by the item 15 of the validated quality of life scale EORTC QLQ-C15 PAL.
Evaluations will take place before the procedure of locoregional analgesia and 1 week after.
|
1 week after first injection
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
change in patient's global quality of life
大体时间：2 days and 1 week after procedure
|
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2 days and 1 week after procedure
|
合作者和调查者
调查人员
- 学习椅：Gérard TERRIER, MD、CHU Limoges
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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