Optimal Flow Rate During Cardiopulmonary Bypass
Regardless of the development of cardiac surgery techniques and technologies, the question of an optimal extracorporeal circulation is still unanswered. There are globally accepted standards of perfusion, however, keep many of these procedures was not evidence-based review.
Generally accepted are flow rates during cardiopulmonary bypasses of 2.5 L/min/m2. This target was derived from the physiological conditions, but they are not the result of an adapted adjustment to the fundamentally non-physiological processes during extracorporeal circulation. Among other things, an increased metabolic demand during re-perfusion is not taken into account.
An increasing and optimizing of the standard flow rate of 0.5 L/min/m2 should be the aim of this investigation. Under optimal perfusion, the investigators are maintaining the microcirculation and organ protection in receipt of endothelial function and oxygen transport.
研究概览
研究类型
注册 (预期的)
阶段
- 不适用
联系人和位置
学习地点
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Frankfurt am Main、德国、60590
- 招聘中
- Johann Wolfgang Goethe University Hospital
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接触：
- Arndt H Kiessling, MD
- 电话号码：6705 +49696301
- 邮箱：arndt.kiessling@kgu.de
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副研究员：
- Arndt H Kiessling, MD
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副研究员：
- Eduard Manherz
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Extracorporeal circulation
- Age > 18
- Written consent
Exclusion Criteria:
- Emergency cases
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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其他：Flow rate
Comparison between a flow rate of 2.5/l/min/m2 versus 3.0/l/min/m2
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Different flow rate during cardiopulmonary bypass
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Microcirulation
大体时间：intraooperative
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measurement with O2C
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intraooperative
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合作者和调查者
出版物和有用的链接
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- CI001AZ-AHK
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