The Acute Effects of Oleic Acid Enriched-diets on Lipids, Insulin Sensitivity and Serum Inflammatory Markers
Objectives: To investigate the acute effects of olive oil, palm olein and lard on lipid profile, insulin sensitivity and inflammatory markers.
Hypothesis: Different dietary fats will alter lipid profile, insulin sensitivity and inflammatory markers postprandially.
研究概览
地位
条件
详细说明
A randomized, single blind, crossover design was undertaken to test meals enriched with palm olein vs olive oil vs lard. Volunteers were asked to participate in three postprandial challenges, separated by at least 3-days. Subjects were provided a low fat meal(<10g fat) the day before the intervention. Fasting blood was collected the next day and the subjects were instructed to consume test meals (50g high fat meal). Further venous blood was collected at 30 min, 1h, 2h, 3h and 4h postprandially.
Primary outcome variable: Triacylglycerol (TAG) Secondary outcome variables: Insulin sensitivity (glucose, insulin), non esterified fatty acids (NEFA), inflammatory markers
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
-
-
Selangor
-
Kajang、Selangor、马来西亚、43000
- Malaysian Palm Oil Board
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Age: 18-45 years
- BMI : 18.5-30 kg/m^2
- Healthy, men
Exclusion Criteria:
- medical history of cardiovascular disease, cancer, diabetes or chronic diseases
- BMI < 18.5 OR > 30 kg/m^2
- waist hip ratio > 0.9
- total cholesterol > 5.2 mmol/L
- triacylglycerol (TAG) > 2.2 mmol/L
- current use of antihypertensive or lipid lowering medication
学习计划
研究是如何设计的？
设计细节
- 主要用途：预防
- 分配：随机化
- 介入模型：交叉作业
- 屏蔽：单身的
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的：palm olein
|
|
|
实验性的：olive oil
|
|
|
实验性的：lard
|
研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
|
Triacylglycerol (TAG)
大体时间：4 h
|
4 h
|
次要结果测量
结果测量 |
大体时间 |
|---|---|
|
Insulin sensitivity (glucose, insulin), non-esterified fatty acids (NEFA), inflammatory markers
大体时间：4 h
|
4 h
|
合作者和调查者
调查人员
- 首席研究员：Teng Kim Tiu, Msc、Malaysia Palm Oil Board and University of Malaya
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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