The Acute Effects of Oleic Acid Enriched-diets on Lipids, Insulin Sensitivity and Serum Inflammatory Markers

May 14, 2010 updated by: Malaysia Palm Oil Board

Objectives: To investigate the acute effects of olive oil, palm olein and lard on lipid profile, insulin sensitivity and inflammatory markers.

Hypothesis: Different dietary fats will alter lipid profile, insulin sensitivity and inflammatory markers postprandially.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

A randomized, single blind, crossover design was undertaken to test meals enriched with palm olein vs olive oil vs lard. Volunteers were asked to participate in three postprandial challenges, separated by at least 3-days. Subjects were provided a low fat meal(<10g fat) the day before the intervention. Fasting blood was collected the next day and the subjects were instructed to consume test meals (50g high fat meal). Further venous blood was collected at 30 min, 1h, 2h, 3h and 4h postprandially.

Primary outcome variable: Triacylglycerol (TAG) Secondary outcome variables: Insulin sensitivity (glucose, insulin), non esterified fatty acids (NEFA), inflammatory markers

Study Type

Interventional

Enrollment (Actual)

10

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Malaysia
    • Selangor
      • Kajang, Selangor, Malaysia, 43000
        • Malaysian Palm Oil Board

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 45 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • Age: 18-45 years
  • BMI : 18.5-30 kg/m^2
  • Healthy, men

Exclusion Criteria:

  • medical history of cardiovascular disease, cancer, diabetes or chronic diseases
  • BMI < 18.5 OR > 30 kg/m^2
  • waist hip ratio > 0.9
  • total cholesterol > 5.2 mmol/L
  • triacylglycerol (TAG) > 2.2 mmol/L
  • current use of antihypertensive or lipid lowering medication

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: palm olein
Dietary supplement: The acute effects of dietary fat on lipid profile, insulin sensitivity and inflammatory markers
Experimental: olive oil
Dietary supplement: The acute effects of dietary fat on lipid profile, insulin sensitivity and inflammatory markers
Experimental: lard
Dietary supplement: The acute effects of dietary fat on lipid profile, insulin sensitivity and inflammatory markers

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Triacylglycerol (TAG)
Time Frame: 4 h
4 h

Secondary Outcome Measures

Outcome Measure
Time Frame
Insulin sensitivity (glucose, insulin), non-esterified fatty acids (NEFA), inflammatory markers
Time Frame: 4 h
4 h

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Malaysia Palm Oil Board

Collaborators

University of Malaya

Investigators

  • Principal Investigator: Teng Kim Tiu, Msc, Malaysia Palm Oil Board and University of Malaya

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

August 1, 2009

Primary Completion (Actual)

September 1, 2009

Study Completion (Actual)

September 1, 2009

Study Registration Dates

First Submitted

May 12, 2010

First Submitted That Met QC Criteria

May 14, 2010

First Posted (Estimate)

May 17, 2010

Study Record Updates

Last Update Posted (Estimate)

May 17, 2010

Last Update Submitted That Met QC Criteria

May 14, 2010

Last Verified

May 1, 2010

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • A001/09

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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