Functional and Clinical Benefits of PCI in Patients With CTO
Multimodality Imaging Evaluation of Functional and Clinical Benefits of Percutaneous Coronary Intervention in Patients With Chronic Total Occlusion Lesion
研究概览
详细说明
Noninvasive imaging modalities have shown high diagnostic accuracy in the detection of coronary artery lesions, and for the estimation of their hemodynamic relevance.Thus, noninvasive assessment of myocardial perfusion defects may be preferred for patients with chronic total occlusion (CTO).
In particular, myocardial perfusion is measured with single photon emission CT (SPECT).Multislice coronary CT angiography (CCTA) with dual-source scanners reveals the anatomic location of coronary artery disease (CAD). These two techniques assess distinct aspects of heart morphology and function parameters of the heart, and should therefore be regarded as complementary rather than competing methods.Taking this into consideration, decisions regarding whether invasive revascularization therapy is adequate or not and which strategy is the best for long-term survival cannot be supported by anatomic information alone. Therefore, noninvasive complementary imaging of structure and perfusion, in conjunction with three-dimensional (3D) image fusion, has emerged as a technique for reliable allocation of perfusion defects to their supplying coronary artery.
研究类型
注册 (预期的)
阶段
- 不适用
联系人和位置
学习地点
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Shaanxi
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Xi'an、Shaanxi、中国、710032
- 招聘中
- Fourth Military Medical University
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接触：
- Dongdong Sun, MD, PhD
- 电话号码：86 13572242509
- 邮箱：wintersun3@gmail.com
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Patients were eligible for enrolment in this study if coronary angiography showed a CTO (at least for 3 months and confirmed by angiography and/or history of earlier MI).
Exclusion Criteria:
- Hypersensitivity to iodinated contrast agent, cardiomyopathy, non-sinus rhythm, severe valvular heart disease, NYHA functional class IV heart failure at baseline, previous coronary bypass surgery, renal insufficiency, severe lung and liver disease or cancer.
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：非随机化
- 介入模型：并行分配
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：Group a
no severe cardiac perfusion defects
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PCI was performed using standard techniques for CTO.
其他名称：
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实验性的：Gooup b
reversible cardiac perfusion defects
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PCI was performed using standard techniques for CTO.
其他名称：
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实验性的：Group c
irreversible cardiac perfusion defects
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PCI was performed using standard techniques for CTO.
其他名称：
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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Left ventricular ejection fraction
大体时间：2year
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2year
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次要结果测量
结果测量 |
大体时间 |
|---|---|
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靶病变血运重建
大体时间：2年
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2年
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cardiac death
大体时间：2year
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2year
|
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Non-fatal myocardial infarction
大体时间：2 year
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2 year
|
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Angina pectoris score index
大体时间：2 year
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2 year
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Six-minute walk distance
大体时间：2 year
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2 year
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合作者和调查者
调查人员
- 首席研究员：Feng Cao, MD, PhD、Air Force Military Medical University, China
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- EFFECT
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生活质量的临床试验
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Swansea University完全的
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Yale-NUS College完全的
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Scripps Translational Science Institute完全的