Study of Individualized Physiotherapy for Airway Clearance in Cystic Fibrosis.

实验性的：Physiotherapy techniques

Cough Technique vs Forced Expiration Technique

其他：Physiotherapy

Physiotherapy for Airway Clearance

Expectorated sputum (gram)

Total amount of expectorated sputum (g) will be collected and weighed wet after each intervention for eight weeks, using a Mettler TOLEDO Weighing Balance (EL 202, accuracy: 0.01 g).

N of 1 trial design. Each trial consist of eight pairs (8 weeks) of treatment periods with two interventions each week (one with Cough Technique and one with Forced Expiration technique), 16 treatments for each participant. Outcome measure after each treatment.

Patient's experience, i.e. perceived utility value and preference of technique.

Utility value: Measured by self-reported questionnaire after completion of each intervention in week 8.

Preference: Measured by three self-reported questions after both interventions in week 8.

Physiological measurements

Oxygen saturation and heart rate measurements in the beginning and at the end of each intervention.

Pulmonary function tests (week 2): measurements before and after each intervention with spirometry.

Health related quality of life (HRQOL)

HRQOL measured by the Cystic Fibrosis Questionnaire Revised (CFQR-R), i.e. respiratory symptoms, in the beginning and at completion of the study.