Mechanisms of Infertility and Hormonal Changes in Patients With Chronic Kidney Disease
Studies of Infertility in Patients With Chronic Kidney Disease
Patients with chronic kidney disease (both men and women), especially those with terminal renal failure, manifest infertility. There has been demonstrated several hormonal changes in patients on dialysis. Increased levels of luteinizing hormone (LH) has been seen in men (12). In women the opposite has been reported. The number of spermatocytes is reduced and a disturbance in maturation has been observed.
This project is aimed to study the influence of uremic milieu on fertility in men and women. The hypopituitary/hypothalamus gland axis and hormonal levels will be studied.
研究概览
地位
条件
详细说明
Renal elimination of hormones and peptides. By using a human transplantation model the investigators will study changes in hormonal levels before and after a successful transplantation up to 12 months. Hormones: testosterone, SHBG (sex hormone binding globulin), LH (luteinizing hormone), FSH (follicle stimulating hormone), estradiol and inhibin B.
Analysis of sperm quality, concentration, motility, morphology and as well DNA-fragmentation index (DFI) in men with chronic kidney disease. In women the investigators will study the maturation of follicles via vaginal ultrasound. Controls are persons from a study at Dept of Reproductive Medicine.
研究类型
联系人和位置
学习地点
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Malmö、瑞典
- Dag Eckersten
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Malmö、瑞典
- SUS, Malmö, Sweden
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- GFR-levels
Exclusion Criteria:
- > 50 years old
学习计划
研究是如何设计的？
设计细节
- 观测模型：病例对照
- 时间观点：预期
队列和干预
团体/队列 |
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renal transplant patients
Patients undergoing transplantation
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dialysis patients
hemodialysis patients and peritoneal dialysis patients.
Before and after a dialysis session
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patients with renal insufficiency
outpatient patients with chronic kidney disease stage 2, 3 and 4
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Chronic kidney disease
outpatient cohort.
Those with mild renal insufficiency
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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concentration of sex hormone levels in plasma
大体时间：up to three years
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up to three years
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次要结果测量
结果测量 |
大体时间 |
|---|---|
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sperm motility
大体时间：up to three years
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up to three years
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合作者和调查者
调查人员
- 首席研究员：Anders Christensson, MD、Lund University
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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