A Study of MK-8109 (Vintafolide) Given Alone or With Chemotherapy in Participants With Advanced Cancers (MK-8109-001)
2015年2月9日 更新者:Endocyte
A Phase I Dose Escalation Study Evaluating Vintafolide (MK-8109) Chemotherapy Alone or in Combination in Adult Subjects With Advanced Cancers
This trial will be conducted in three parts.
Part A is a dose escalation trial followed by a dose confirmation trial in folate receptor (FR) 100% endometrial cancer participants.
The primary hypothesis of this trial is that administration of vintafolide in combination with carboplatin and paclitaxel is safe and tolerable.
Part B is a single dose, dose escalation, pharmacokinetic (PK), and QTc interval trial.
The primary objectives include determination of the maximum single tolerated dose of vintafolide and to evaluate the effect of this single maximum dose on the QTc interval.
Part C is a weekly dose escalation trial of vintafolide followed by a dose confirmation.
The primary hypothesis of this part is that weekly vintafolide has acceptable safety and tolerability in participants with advanced cancers.
研究概览
研究类型
介入性
注册 (实际的)
37
阶段
- 阶段1
参与标准
研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
18年 及以上 (成人、年长者)
接受健康志愿者
不
有资格学习的性别
全部
描述
Inclusion criteria for all participants:
- Histologically-confirmed metastatic or locally advanced solid tumor that has failed to respond to standard therapy, progressed despite standard therapy, or for which standard therapy does not exist or is unacceptable to the participant
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- At least one measurable metastatic or recurrent lesion
- No history of a previous malignancy with the exception of cervical intraepithelial neoplasia, basal cell carcinoma of the skin, or adequately treated localized prostate carcinoma; or has undergone potentially curative therapy with no evidence of disease for five years
- Adequate organ function
- Female participants of childbearing potential must be willing to use acceptable methods of birth control or abstain from heterosexual activity for the course of the study through 90 days after the last dose of study therapy
- Male participants must agree to use an adequate method of contraception for heterosexual activity starting with the first dose of study therapy through 90 days after the last dose of study therapy
Inclusion criteria for Part A:
- Tumor lesions characterized as folate receptor (FR) 100% as determined by an etarfolide Sequential Single Photon Emission Computed Tomography (SPECT) and CT scan
- Histologically-confirmed diagnosis of locally advanced or metastatic or recurrent endometrial cancer
Inclusion criteria for Parts B & C:
- Must have an etarfolatide SPECT/CT scan to determine FR status
Exclusion criteria for all participants:
- Part A & Part C if enrolled after completion of Part B: Chemotherapy, radiotherapy, or biological therapy (including monoclonal antibodies) within 4 weeks prior to drug administration, or not recovered from adverse events due to agents administered more than 4 weeks earlier
- Part B: Chemotherapy, radiotherapy, or biological therapy (including monoclonal antibodies) within 3 weeks prior to drug administration, or not recovered from adverse events due to agents administered more than 4 weeks earlier
- Currently participating or has participated in a study with an investigational compound or device within 28 days of initial dosing on this study
- Part A, dose escalation, Parts B and C: More than 3 prior cytotoxic regimens for metastatic disease.
- Part A, dose confirmation: Has received more than 2 prior cytotoxic regimens for metastatic disease.
- Primary central nervous system (CNS) tumor
- Active CNS metastases and/or carcinomatous meningitis.
- Known hypersensitivity to the components of the study therapy or its analogs
- Recent (i.e., ≤ 6 weeks) history of abdominal surgery or peritonitis
- Bowel occlusion or sub-occlusion
- Prior whole abdominal or whole pelvis radiation therapy or radiation therapy to >10% of the bone marrow at any time in the past or prior radiation therapy within the last 3 years to the breast / sternum, head, or neck
- Requires anti-folate therapy for the management of co-morbid conditions
- Known regular user (including "recreational use") of any illicit drugs or had a recent history (within the last year) of drug or alcohol abuse
- Pregnant or breastfeeding or expecting to conceive, or donate sperm within the span of the study
- Human Immunodeficiency Virus (HIV)-positive
- Active Hepatitis B or C
- Symptomatic ascites or pleural effusion.
- History of stem cell or bone marrow transplant
Exclusion Criteria for Part B:
- Permanent pacemaker
- Unable to refrain from use of all concomitant medications on Day 1
- Structural heart disease, history of myocardial infarction (MI), or unstable angina
- History of cardiac arrhythmia, congestive heart failure (CHF), sick sinus syndrome, second or third degree atrioventricular (AV) block
- History of risk factors for Torsades de Pointes such as CHF, uncorrected hypokalemia, family history of long QT syndrome
学习计划
本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。
研究是如何设计的?
设计细节
- 主要用途:治疗
- 分配:非随机化
- 介入模型:并行分配
- 屏蔽:无(打开标签)
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的:Part A: Vintafolide BIW
Vintafolide, intravenously (IV), on Days 1, 4, 8, and 11 of each 21-day cycle.
Carboplatin, IV, at a dose of area under the curve (AUC)5, administered on Day 1 of each 21-day cycle.
Paclitaxel, IV, at a dose of 175 mg/m^2, administered on Day 1 of each 21-day cycle
|
其他名称:
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实验性的:Part A: Vintafolide TIW
Vintafolide, intravenously (IV) on Days 1, 3, 5, 8, 10, and 12 of each 21-day cycle.
Carboplatin, IV, at a dose of area under the curve (AUC)5, administered on Day 1 of each 21-day cycle.
Paclitaxel, IV, at a dose of 175 mg/m^2, administered on Day 1 of each 21-day cycle
|
其他名称:
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实验性的:Parts B & C: Vintafolide Single Dose & Weekly (QW)
Single dose, dose escalation, vintafolide (Part B) followed by 2 week observation.
Those completing Part B will have the option to continue on to Part C (weekly dosing, dose finding, on Days 1, 8, and 15 in a 21-day cycle until disease progression or toxicity) unless they experience severe and/or persistent drug related toxicity.
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其他名称:
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研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
|---|---|
|
Parts A and C: Number of participants with dose-limiting toxicities (DLTs)
大体时间:Cycle 1 (21 days)
|
Cycle 1 (21 days)
|
|
Part B: Change from Baseline in QTc interval
大体时间:30 minutes pre-dose and up to 2 hours post-dose
|
30 minutes pre-dose and up to 2 hours post-dose
|
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Part C: Number of Participants Experiencing an Adverse Event (AE)
大体时间:Up to 18 weeks (six 3-week cycles)
|
Up to 18 weeks (six 3-week cycles)
|
次要结果测量
结果测量 |
大体时间 |
|---|---|
|
Number of participants whose best response is partial response (PR) or complete response (CR)
大体时间:Week 6
|
Week 6
|
|
Progression free survival
大体时间:Week 6
|
Week 6
|
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Disease control rate
大体时间:Week 6
|
Week 6
|
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Part B: Pharmacokinetics (PK) of vintafolide, including Area Under the Curve (AUC) and Maximum Concentration (Cmax)
大体时间:Day 1
|
Day 1
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Part B: PK of Vintafolide Metabolites, including AUC and Cmax
大体时间:Day 1
|
Day 1
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
赞助
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始
2012年12月1日
初级完成 (实际的)
2014年9月1日
研究完成 (实际的)
2014年9月1日
研究注册日期
首次提交
2012年9月17日
首先提交符合 QC 标准的
2012年9月17日
首次发布 (估计)
2012年9月20日
研究记录更新
最后更新发布 (估计)
2015年2月10日
上次提交的符合 QC 标准的更新
2015年2月9日
最后验证
2015年2月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.