Study About High Fat Meal and Postprandial Lipemia
Evaluating the Effect of Lipid Overload in Endothelial Function and Microvascular Reactivity in Young Obese Women
The hypothesis of the proposed project is that after a fat overload, the postprandial response is different in both groups, suggesting that the LPP will present the most significant damage in endothelial vasomotion in obese individuals, especially those with GI and T2DM. After the fat overload, we hypothesized that there will be a worsening of endothelial function and microvascular reactivity in OB/DM2 and OB group compared to C, but also find lower concentrations of incretins in OB/DM2 group compared to other groups.
These hypotheses may be confirmed by techniques for evaluating microvascular function, the use of DFT skin for vasomotion evaluation and finally analysis of analytes through metabolic and cardiovascular read by Multiplex kit.
研究概览
详细说明
Will be recruited 60 women aged 19-40 years, with a diagnosis of obesity (BMI ≥ 30 kg/m2) treated at the obesity clinic at the State University of Rio de Janeiro (UERJ)at Brazil.
Microcirculation parameters and blood tests will be assessed at baseline and after this, the women will receive a high-fat meal containing croissant, salami, whole milk and cheddar cheese. After 30, 60, 120 and 180 minutes this meal the microcirculation will be evaluated as well as blood collection.
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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Rio de janeiro、巴西、20550900
- Rio de Janeiro State University
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- all patients should have obesity class I (BMI between 30 and 35kg/m2);
- Submit diabetes mellitus without further treatment or be obese non-diabetic or glucose intolerant;
- Presenting the age between 19 to 40 years.
- Waist circumference> 80 cm (IDF)
Exclusion Criteria:
- Renal disease, coronary or peripheral vascular, hematologic or hepatic impairment;
- Presence of dyslipidemia;
- smokers;
- Significant loss of body weight six months prior to the study.
学习计划
研究是如何设计的？
设计细节
- 主要用途：诊断
- 分配：非随机化
- 介入模型：并行分配
- 屏蔽：单身的
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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其他：Obese Group
Obese group with fat overload intake.
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其他：Control Group
Control Group + fat overload intake
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其他：Glucose Intolerance
glucose intolerance + fat overload intake
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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Microvascular function
大体时间：up to 180 minutes after high fat meal
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up to 180 minutes after high fat meal
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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incretins hormones
大体时间：basal, 30, 60, 120,180 minutes after high fat meal
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We will assess incretins hormones by multiplex
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basal, 30, 60, 120,180 minutes after high fat meal
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合作者和调查者
出版物和有用的链接
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- Biovasc-02
- Biovasc002 (注册表标识符：Over load project)
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.