Variation of Aortic Compliance Related to Exercise Training With or Without Supervised Sessions (ACT)
Exercise Training in Patients With Cardiovascular Risk: Predictability of Aortic Compliance Normalization
Many conditions and cardiovascular diseases (including stroke) are better managed with regular exercise training. The expected effects are partial reversal of adverse effects on heart and blood vessel structure and function, improved glycemic, tension and weight control.
Physiologically, the aorta maintains low left ventricular after-load, promotes optimal sub-endocardial coronary blood flow, and transforms pulsatile into laminar blood flow. Increased aortic stiffness may ultimately contribute to left ventricular dysfunction. Regular exercise training is likely to decrease the pulse wave velocity (a measure of the aortic compliance). Some subjects seem more responsive than others, and they may not expect the same benefit of exercise training. To the best of our knowledge, this has not been explained yet.
研究概览
研究类型
注册 (预期的)
阶段
- 不适用
联系人和位置
学习地点
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Pointe à Pitre、瓜德罗普岛
- 招聘中
- CHU de Pointe à Pitre
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接触：
- Sophie ANTOINE-JONVILLE, Ph.D.
- 邮箱：s_antoine@ymail.com
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首席研究员：
- Cosmin ALECU, MD
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副研究员：
- Annie LANNUZEL, MD
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首席研究员：
- Anne BLANCHET, MD
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副研究员：
- Rachel BILLY-BRISSAC, MD
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首席研究员：
- Patrick FOUCAN, MD
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Fort de France、马提尼克岛
- 招聘中
- CHU de Fort de France
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接触：
- Armelle JEAN-ETIENNE, MD
- 邮箱：Armelle.Jean-Etienne@chu-fortdefrance.fr
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副研究员：
- Patrick RENE-CORAIL, MD
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副研究员：
- Jocelyn INAMO, MD
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副研究员：
- Stéphane OLINDO, MD
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- patients aged 50-69 years, with moderate or high cardiovascular risk
Exclusion Criteria:
- any physical or medical problem liable to limit the patient' ability to perform the cardiopulmonary exercise testing or the exercise training in safe conditions.
学习计划
研究是如何设计的？
设计细节
- 主要用途：支持治疗
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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有源比较器：Medical supervision
Exercise training with supervised sessions Classics training
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有源比较器：No medical supervision
Exercise training without supervised sessions Classics training
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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Pulse wave velocity
大体时间：With or without the exercise training
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With or without the exercise training
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次要结果测量
结果测量 |
大体时间 |
|---|---|
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Heart rate variability
大体时间：within 12 weeks after exercise training
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within 12 weeks after exercise training
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合作者和调查者
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.