Effect of Alveolar Minute Ventilation on Respiratory Gas Heat Content
研究概览
地位
条件
详细说明
研究类型
注册 (实际的)
联系人和位置
学习地点
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California
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Sacramento、California、美国、95817
- UC Davis Health System
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- age greater than 18 years
- scheduled for an elective surgical procedure with an anticipated duration of more than 2 hours requiring general anesthesia and positive pressure ventilation using an endotracheal tube
- patient status ASA 1, 2 or 3
- no significant cardio-vascular or respiratory disease
- supine surgical position
Exclusion Criteria:
- Adults unable to give primary consent
- age less than 18 years
- pregnancy
- prisoners
- pre-existing cardiac or pulmonary disease
- infusion of inotropic drugs
- positive end expiratory pressure (PEEP) requirements >8 cm H2O
- increased intra-abdominal pressure (e.g. planned surgical pneumoperitoneum or ascitis)
- intra-operative patient position other than supine
学习计划
研究是如何设计的？
设计细节
- 观测模型：队列
- 时间观点：预期
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
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6ml/kg
Enthalpy measured in patients receiving controlled positive pressure ventilation 6ml/kg Tidal volume. The VQm monitor samples the gas at a rate of 3 L/min, returning the analyzed gas to the circuit. As the exhaled gas passes through the analytical chamber, the temperature and humidity are measured essentially continuously (40Hz). These data are combined with pressure measurements to determine the exhaled gas volume and then the heat content (enthalpy) is calculated. |
controlled positive pressure ventilation 6ml/kg tidal volume
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9ml/kg
Enthalpy measured in patients receiving controlled positive pressure ventilation 9ml/kg Tidal volume. The VQm monitor samples the gas at a rate of 3 L/min, returning the analyzed gas to the circuit. As the exhaled gas passes through the analytical chamber, the temperature and humidity are measured essentially continuously (40Hz). These data are combined with pressure measurements to determine the exhaled gas volume and then the heat content (enthalpy) is calculated. |
controlled positive pressure ventilation 9ml/kg tidal volume
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Airway Enthalpy
大体时间：12 months
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This is a single site, prospective, non-blinded, non-randomized, non-interventional study designed to evaluate the effect of changes in alveolar minute ventilation on the measurement of respiratory heat loss (enthalpy) in Joules per minute.
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12 months
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合作者和调查者
调查人员
- 首席研究员：Neal Fleming, MD, PhD、Professor, Anesthesiology & Pain Medicine
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.
通气灌注不匹配的临床试验
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Tianjin Huanhu Hospital完全的