The Effect of Dietary Sugar Consumption on Sweet Taste Perception
2014年3月14日 更新者：Paul Wise、Monell Chemical Senses Center
The purpose of the study is to determine how reducing the amount of simple sugars in the diet affects sweet taste perception. Healthy adult subjects will be assigned to either follow their usual diet, or to replace sugar calories with fats or starch.
The investigators hypothesize that eating less sugar will:
- cause foods and drinks with a given amount of sugar to taste sweeter
- cause people to prefer lower levels of sugar in foods and drinks
研究概览
研究类型
介入性
注册 (实际的)
50
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习地点
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Pennsylvania
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Philadelphia、Pennsylvania、美国、19014
- Monell Chemical Senses Center
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参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
18年 至 60年 (成人)
接受健康志愿者
是的
有资格学习的性别
全部
描述
Inclusion Criteria:
- Good general heath (by self report)
- Consume at least 2 sugar-containing soft drinks/day on average)
- Able to control diet (select their own foods)
Exclusion Criteria:
- Major illness of any kind within the last six months, or any chronic illness
- Daily use of medication, except for birth control, vitamins, and aspirin
- Regularly consume non-nutritive sweeteners
- Pregnant women
- Gained or lost 10% or more of their body weight in the last 3 months
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
- 主要用途：基础科学
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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假比较器：No change in dietary sugar levels
Group met with a dietician as often as the control group to discuss diet, but the dietician gave them advice geared toward no change in dietary sugar levels
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Subjects in the control group will meet with a dietician and discuss diet records, but the dietician will not instruct the control subjects to reduce the number of calories from simple sugars in the diet
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实验性的：Low sugar group
Subjects met with a dietician who discussed diet records.
After the first month (baseline, regular diet), the dietician made suggestions geared toward reducing calories from simple sugars by 40%.
This will be achieved by replacing sugar calories with complex carbohydrates and fats, while maintaining energy balance (same number of calories as the baseline month).
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All subjects followed their usual diet during month 1.
For months 2-4: sham diet intervention for the control group, 40% reduction in sugar calories for the experimental group.
All subjects were allowed to chose any diet they wished during month 5.
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Change in Sweet Taste Intensity over Five Months
大体时间：Monthly (for five months)
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Subjects rated the sweetness of pudding and beverage samples that varied in sucrose concentration during each study month to determine how perception changes over time with diet manipulations
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Monthly (for five months)
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Change in Pleasantness Over Five Months
大体时间：Monthly (five month participation duration total)
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Subjects rated hedonic value (degree to which the sample was pleasant) for model pudding and beverages that differed in concentration of sucrose once each month over five months to determine how perception changed over time with the diet manipulation
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Monthly (five month participation duration total)
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Sucrose detection thresholds
大体时间：Every month (for five months)
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Test of the minimum concentration of sucrose solution that subjects can discriminate from water.
Forced-choice, ascending concentration method.
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Every month (for five months)
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Body mass index
大体时间：Every month (five months total)
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BMI, calculated based on weight and height.
This was measured both to balance treatment groups and to ensure that assigned diets maintained adequate energy balance (no change in BMI over the study was the ideal outcome for all groups)
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Every month (five months total)
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Diet records
大体时间：Every month (five month total)
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Subject reported in detail the types and quantities of the foods and beverages they ate.
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Every month (five month total)
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始
2010年10月1日
初级完成 (实际的)
2011年6月1日
研究注册日期
首次提交
2014年3月13日
首先提交符合 QC 标准的
2014年3月14日
首次发布 (估计)
2014年3月18日
研究记录更新
最后更新发布 (估计)
2014年3月18日
上次提交的符合 QC 标准的更新
2014年3月14日
最后验证
2014年3月1日
更多信息
与本研究相关的术语
其他研究编号
- IND039A01WISE
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.
Sham diet manipulation的临床试验
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Rush University Medical CenterUniversity of Chicago; National Institute on Aging (NIA); Advocate Hospital System招聘中
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University of CalgaryStewart Diabetes Education Fund完全的