此页面是自动翻译的,不保证翻译的准确性。请参阅 英文版 对于源文本。

Frailty Status and Quality of Life in Elderly

2015年1月6日 更新者:Siti Setiati、Indonesia University

A Cohort Study of Frailty Status Transition and Its Impact to Quality of Life in Outpatient Elderly

Frailty is a dynamic process from fit (robust) and pre-frail elderly. There is no previous study that determine the risk factors from fit to pre-frailty and pre-frailty to frailty in Indonesian elderly.

This study was aimed to define the risk factors of frailty transitional status and its correlation with quality of life in Indonesian elderly outpatients.

研究概览

地位

完全的

详细说明

Frailty is an age-associated, biological syndrome characterized by decreased biological reserves, due to dysregulation of several physiological systems, which puts an individual at risk when facing minor stressors, and is associated with poor outcomes (ie, disability, death, and hospitalization).

Frailty identifies a high-risk subgroup and off ers characteristics of great clinical importance: a higher reversibility at early stages than disability, and a higher predictive value than chronic disease for adverse outcomes at older ages. It is also the most common condition leading to death in community-dwelling older people.

However, there is current consensus that physical frailty is potentially reversible. It is hence useful to objectively detect frailty among frail elderly persons, as frailty indices serve a useful purpose for risk stratification, predicting need for institutional care and planning of services needed.

To date, there is no study or information about frailty status in Indonesia elderly. This study was aimed to define the risk factors of frailty transitional status and its correlation with quality of life in Indonesian elderly.

研究类型

观察性的

注册 (实际的)

269

参与标准

研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

60年 及以上 (成人、年长者)

接受健康志愿者

不

有资格学习的性别

全部

取样方法

非概率样本

研究人群

Fit or pre-frail elderly aged >= 60 years old who came to Comprehensive Geriatric Clinics, Cipto Mangunkusumo General Hospital, Jakarta, during March 2013-April 2014.

描述

Inclusion Criteria:

  1. Elderly aged >= 60 years old
  2. Fit (robust) or pre-frailty;
  3. Capable to understand and carry-out the instruction.

Exclusion Criteria:

  1. Unwilling to join the study;
  2. Abbreviated Mental Test (AMT) score < 8;
  3. Geriatric Depression Scale (GDS) score >= 10;
  4. Body mass index (BMI) <18,5 Kg/m2;
  5. Malnutrition (according to Mini Nutritional Assessment/MNA);
  6. Liver cirrhosis, severe liver dysfunction, or serum ALT levels >3 times upper normal limit;
  7. Acute illness during inclusion period, eg. pneumonia, pain due to acute arthritis (visual analog scale >6/10), stroke attack, crisis hypertension;
  8. Severe cardiac dysfunction: acute decompensated heart failure and/or chronic heart failure functional class III or IV (New York Heart Association classification);
  9. Severe pulmonary dysfunction: acute exacerbation of chronic obstructive lung disease stage III or IV (GOLD classification), and/or PaO2 levels < 60 mmHg.

学习计划

本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。

研究是如何设计的?

设计细节

  • 观测模型:队列
  • 时间观点:预期

研究衡量的是什么?

主要结果指标

结果测量
措施说明
大体时间
Change from baseline in frailty status at 24 months
大体时间:Baseline and at 24 months
Frailty status is divided into Fit (robust), Pre-frail, and Frailty.
Baseline and at 24 months

次要结果测量

结果测量
措施说明
大体时间
Change from baseline in mortality at 24 months
大体时间:at 24 months
Mortality: number of subjects died after 24 months observation.
at 24 months
Change from baseline in morbidities at 24 months
大体时间:Baseline and at 24 months
Morbidities: number of diseases in subjects (using Charlson Comorbidity Index)
Baseline and at 24 months

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

调查人员

  • 首席研究员:Siti Setiati, Prof, MD、Division of Geriatrics, Department of Internal Medicine, Universitas Indonesia-Cipto Mangunkusumo General Hospital, Jakarta
  • 学习椅:Purwita Laksmi, MD、Division of Geriatrics, Department of Internal Medicine, Universitas Indonesia-Cipto Mangunkusumo General Hospital, Jakarta
  • 学习椅:Rahmi Istanti, SKM, MARS、Division of Geriatrics, Department of Internal Medicine, Universitas Indonesia-Cipto Mangunkusumo General Hospital, Jakarta

出版物和有用的链接

负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始

2013年3月1日

初级完成 (实际的)

2014年4月1日

研究完成 (实际的)

2014年12月1日

研究注册日期

首次提交

2015年1月2日

首先提交符合 QC 标准的

2015年1月6日

首次发布 (估计)

2015年1月7日

研究记录更新

最后更新发布 (估计)

2015年1月7日

上次提交的符合 QC 标准的更新

2015年1月6日

最后验证

2015年1月1日

更多信息

与本研究相关的术语

此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.

订阅