Bariatric Surgery for the Treatment of Type 2 Diabetes - Clinical Effects and Underlying Mechanisms (Bariglykos)

Inclusion Criteria:

• Males and females aged 18-60 years
• Type 2 Diabetes Mellitus with duration of no more than 10 years, treated with 0-3 oral anti-diabetic drugs or Glucagon-like peptide-1 (GLP-1) analog.

Exclusion Criteria:

• Pregnant or planning to be pregnant during the study.
• Known or suspected history of significant drug abuse.
• History of alcohol abuse or excessive intake of alcohol as judged by investigator.
• History of severe allergy/hypersensitivity or ongoing allergy/hypersensitivity, as judged by the investigator
• Sleep apnea
• Any previous serious cardiovascular event, stroke , acute myocardial infarction.
• Diabetes complications : proliferative retinopathy, maculopathy, chronic renal failure stadium 3 with an Estimated Glomerular Filtration Rate (eGFR) <60, foot ulcers, symptomatic neuropathy
• Medications within 3 months : Insulin, Thiazolidinediones
• Any other condition with in the opinion of the investigator would render the patient unsuitable for inclusion in the study and /or for the patients safety
• Judgment by the investigator that the subject should not participate in the study if considers subject unlikely to comply with study procedures, restrictions and requirements.