Post-natal Depression and Chronic Stress (serene)
Chronic Stress Protection for Post-natal Depression Prevention: An Exploratory Study
The risk of emergence of a post natal depression is based on an interaction between a maternal psychic vulnerability and a chronic environmental context of stress. The PND appears as a relevant model for studying the mechanisms of chronic stress and vulnerability to psychological pathologies.
This study aim to follow a cohort of pregnant women to determine the predictive psychobiological factors of the emergence of postnatal depression
研究概览
地位
条件
详细说明
The prevalence of postnatal depression is high in civilian settings (20%). In mechanistic terms, the risk of emergence of a post natal depression is based on an interaction between a maternal psychic vulnerability and a chronic environmental context of stress. The post natal depression appears as a relevant model for studying the mechanisms of chronic stress and vulnerability to psychological pathologies.
- On the one hand, the repetition of stressors during pregnancy corresponds to a natural chronic stress model of several months and thus allows to study the biological cost of responses to repeated stresses, and the adaptive mechanisms leading to From functional drift to psychic dysfunction.
- On the other hand, isolated vulnerability factors characterize a mirroring psychological profile of a Mindfulness type of functioning. Mindfulness or full consciousness has been described as a state of consciousness which results from intentionally, at the present moment, without judging the experience that unfolds moment by moment. This psychological resource has been associated with resilient or even resilient psychic functioning.
This study aim to follow a cohort of pregnant women from the first trimester of pregnancies to 2 months after the delivery to determine the predictive psychobiological factors of the emergence of postnatal depression
研究类型
注册 (实际的)
联系人和位置
学习地点
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Not In US/Canada
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Brétigny-sur-Orge、Not In US/Canada、法国、91223
- Marion Trousselard
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Physiological pregnancy
- Follow-up of pregnancy in a participating maternity
- Female over 18 years
- Affiliated to a social security scheme
Exclusion Criteria:
- Multiple pregnancy
- Psychiatric, neurological, or endocrine or autoimmune diseases
- Hormonal or psychotropic treatments
学习计划
研究是如何设计的？
设计细节
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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post natal depression
大体时间：baseline at three 3 months of pregnancy and two months after labour delivery
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change in Edimbourg Post-Partum Depression scale at two months after labour delivery
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baseline at three 3 months of pregnancy and two months after labour delivery
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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allostatic load as a composite index including blood GABA, BDNF and 8iso-Prostaglandins and capillary cortisol + heart rate variability index
大体时间：baseline at three 3 months of pregnancy and two months after labour delivery
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change in allostatic load two months after labour delivery
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baseline at three 3 months of pregnancy and two months after labour delivery
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其他结果措施
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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psychological functioning as a composite index including well-being, and stress control
大体时间：baseline at three 3 months of pregnancy and two months after labour delivery
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change in psychological functioning two months after labour delivery
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baseline at three 3 months of pregnancy and two months after labour delivery
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合作者和调查者
出版物和有用的链接
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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