Healing Effects of Autologous Platelet Rich Plasma on Gastric Ulcer Caused by Endoscopic Submucosal Dissection
研究概览
详细说明
Background:In Korea, where the prevalence of gastric tumors is high, the use of ESD as a treatment for gastric cancer will continue to increase. Considering that there are no special measures to prevent side effects (bleeding, perforation, etc.) of this procedure, it is possible to reduce the large medical costs through the discovery of substances that can promote gastric mucosal healing. Platelet-rich plasma (PRP) has demonstrated efficacy in preclinical endoscopic resection models.
Aim: Evaluate the efficacy of PRP on participants submitted to ESD.
Material and Methods: The investigators have evaluated a prospective clinical study. The investigators have included 10 participants submitted to ESD. Patients were informed and accepted to participate with a written consent. Prior to endoscopy PRP was obtained from autologous blood with a commercial kit. Resection was performed with standard technique. Immediately after the procedure, autologous PRP is applied to the artificial gastric ulcer using endoscopic spray. Participants were followed-up after the procedure.
研究类型
注册 (实际的)
阶段
- 第三阶段
联系人和位置
学习地点
-
-
Jung-gu
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Daegu、Jung-gu、大韩民国、700-712
- KeimyungUniversity
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Endoscopic lesion submitted to endoscopic resection (ESD)
Exclusion Criteria:
- Ineligibility to endoscopic resection
- Patients who declined to participate in this study
- Patients who had hematologic diseases
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：单身的
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的：Apply platelet rich plasma to the artificial gastric ulcer
|
The experimental group was treated with PRP for artificial gastric ulcer after ESD.
其他名称：
|
|
安慰剂比较：Apply normal saline to the artificial gastric ulcer
|
The control group was treated with normal saline for artificial gastric ulcer after ESD.
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Recovery of artificial gastric ulcer
大体时间：2 weeks
|
Measure the ulcer size with an endoscopy.
|
2 weeks
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Recovery of artificial gastric ulcer
大体时间：4 weeks
|
Measure the ulcer size with an endoscopy.
|
4 weeks
|
|
Occurrence of postprocedure complication
大体时间：2 weeks
|
Postprocedure complications were investigated by patient examination and endoscopy.
|
2 weeks
|
|
Occurrence of postprocedure complication
大体时间：4 weeks
|
Postprocedure complications were investigated by patient examination and endoscopy.
|
4 weeks
|
合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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