Effects of Core Stability Training on Gait in Multiple Sclerosis Patients
2018年2月15日 更新者：Baris Cetin、Hacettepe University
Randomized Controlled Trial of Core Stability Training in Patients With Multiple Sclerosis: Biomechanical and Performance Based Analysis of Gait
Gait and mobility are among the functions frequently affected in Multiple Sclerosis (MS) and have a negative impact on quality of life.
Strength losses in lower limb muscles, ataxia, sensory problems and fatigue are the most important reasons of walking problems in patients with MS.
In addition to loss of strength and tonus problems, especially biomechanical disorders can be seen on foot and this problem affects gatin and balance negatively.
The stabilizing muscles, defined as the "core" region and enveloping the body like a corset, are active in the context of postural preparation prior to lower extremity movements and stabilize for the limb movements to be performed.
The aim of this study was to investigate the effects of spinal stabilization exercises on walking performance, fatigue, plantar pressure distribution, balance, muscle strength and quality of life in patients with Multiple Sclerosis.
研究概览
研究类型
介入性
注册 (实际的)
68
阶段
- 不适用
参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
18年 及以上 (成人、年长者)
接受健康志愿者
不
有资格学习的性别
全部
描述
Inclusion Criteria:
- Older than 18 years old
- EDSS score is between 3-5,5
- Patients who did not take corticosteroid therapy within three months
- Patients who get at least 24 points from the Mini Mental Test were included in the study.
Exclusion Criteria:
- Patients who had an acute MS attack or had an attack within the last three months.
- An orthopedic or systemic problem that would prevent participation in exercises
- Patients who were using walking orthoses or walking aids were not included in the study.
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的：Study group
Spinal stabilization exercises in addition to home exercise program
|
Study group : In addition to home program spinal stabilization exercises
|
|
有源比较器：Control Group
Home exercise program
|
Home exercise program
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
6 Minutes Walk Test
大体时间：Change from Baseline 6 Minutes Walking Distance at 6 weeks.
|
Maximum Walking Distance in 6 Minutes
|
Change from Baseline 6 Minutes Walking Distance at 6 weeks.
|
|
Modified Borg Scale
大体时间：Change from Baseline Fatigue Score at 6 weeks.
|
Evaluating fatigue between the scores of 0 and 10. "0" means no fatigue at all.
"10" means maximal fatigue.
|
Change from Baseline Fatigue Score at 6 weeks.
|
|
Plantar Pressure Distribution
大体时间：Change from baseline peak pressure and contact area values at 6 weeks
|
Peak pressure values of 10 subregions under the foot
|
Change from baseline peak pressure and contact area values at 6 weeks
|
|
Plantar Pressure Distribution
大体时间：Change from baseline peak pressure and contact area values at 6 weeks
|
Contact area values of 10 subregions under the foot
|
Change from baseline peak pressure and contact area values at 6 weeks
|
|
Multiple Sclerosis Quality of Life Scale
大体时间：Change from baseline mental and physical quality of life scores at 6 weeks
|
Quality of life assessment with 54 questions about mental and physical health in daily life activities.
|
Change from baseline mental and physical quality of life scores at 6 weeks
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Muscle strength with hand held dynamometer
大体时间：Change from baseline muscle strength at 6 weeks
|
Hip Flexors Muscle Strength
|
Change from baseline muscle strength at 6 weeks
|
|
Muscle strength with hand held dynamometer
大体时间：Change from baseline muscle strength at 6 weeks
|
Hip Abductors Muscle Strength
|
Change from baseline muscle strength at 6 weeks
|
|
Muscle strength with hand held dynamometer
大体时间：Change from baseline muscle strength at 6 weeks
|
Knee Flexors Muscle Strength
|
Change from baseline muscle strength at 6 weeks
|
|
Muscle strength with hand held dynamometer
大体时间：Change from baseline muscle strength at 6 weeks
|
Knee Extensors Muscle Strength
|
Change from baseline muscle strength at 6 weeks
|
|
Muscle strength with hand held dynamometer
大体时间：Change from baseline muscle strength at 6 weeks
|
Ankle Dorsiflexors Muscle Strength
|
Change from baseline muscle strength at 6 weeks
|
|
MiniBESTest
大体时间：Change from baseline MiniBESTest scores at 6 weeks
|
Static and dynamic balance evaluation.
This test includes 14 items and maximum score is 28.
28 points means best balance status.
|
Change from baseline MiniBESTest scores at 6 weeks
|
|
Dynamic Gait Index
大体时间：Change from baseline Dynamic Gait Index scores at 6 weeks
|
Dynamic balance evaluation especially walking balance.
This test includes 8 items and maximum score is 24.
Maximum score means best dynamic balance status.
|
Change from baseline Dynamic Gait Index scores at 6 weeks
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
一般刊物
- Bethoux F. Gait disorders in multiple sclerosis. Continuum (Minneap Minn). 2013 Aug;19(4 Multiple Sclerosis):1007-22. doi: 10.1212/01.CON.0000433286.92596.d5.
- Givon U, Zeilig G, Achiron A. Gait analysis in multiple sclerosis: characterization of temporal-spatial parameters using GAITRite functional ambulation system. Gait Posture. 2009 Jan;29(1):138-42. doi: 10.1016/j.gaitpost.2008.07.011. Epub 2008 Oct 31.
- Freeman JA, Gear M, Pauli A, Cowan P, Finnigan C, Hunter H, Mobberley C, Nock A, Sims R, Thain J. The effect of core stability training on balance and mobility in ambulant individuals with multiple sclerosis: a multi-centre series of single case studies. Mult Scler. 2010 Nov;16(11):1377-84. doi: 10.1177/1352458510378126. Epub 2010 Aug 10.
- Hides J, Wilson S, Stanton W, McMahon S, Keto H, McMahon K, Bryant M, Richardson C. An MRI investigation into the function of the transversus abdominis muscle during "drawing-in" of the abdominal wall. Spine (Phila Pa 1976). 2006 Mar 15;31(6):E175-8. doi: 10.1097/01.brs.0000202740.86338.df.
- Freeman J, Fox E, Gear M, Hough A. Pilates based core stability training in ambulant individuals with multiple sclerosis: protocol for a multi-centre randomised controlled trial. BMC Neurol. 2012 Apr 5;12:19. doi: 10.1186/1471-2377-12-19.
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2015年1月1日
初级完成 (实际的)
2016年2月20日
研究完成 (实际的)
2016年5月1日
研究注册日期
首次提交
2018年1月25日
首先提交符合 QC 标准的
2018年2月15日
首次发布 (实际的)
2018年2月22日
研究记录更新
最后更新发布 (实际的)
2018年2月22日
上次提交的符合 QC 标准的更新
2018年2月15日
最后验证
2018年2月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.