此页面是自动翻译的，不保证翻译的准确性。请参阅英文版对于源文本。

The Biological Rhythm of Human Metabolite

2022年5月10日更新者：Jia-jun Zhao、Shandong Provincial Hospital

Association Between Serum Metabolism Markers and Biological Rhythm

The circadian regulation in mammals have been known for a long time. A special group of clock genes, organized in feedback loops, are responsible for the circadian regulation in both the SCN and peripheral organs. The central clock is mainly entrained by the light-dark cycle, while the peripheral ones in organs such as liver and intestine, are more influenced by the feeding-fasting cycles. The coordination of central and peripheral clocks is thought to be essential in the maintenance of physiological homeostasis.This study aim to investigate the association between biological rhythm and metabolism.

研究概览

地位

招聘中

条件

研究类型

观察性的

注册 (预期的)

200

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习联系方式

姓名：Ling Gao
电话号码：+86 53168776910
邮箱：gaoling1@medmail.com.cn

学习地点

中国
- Shandong
  - Jinan、Shandong、中国、250021
    - 招聘中
    - Shandong Provincial Hospital

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年至 30年 (成人)

接受健康志愿者

不

有资格学习的性别

全部

取样方法

概率样本

研究人群

Adults aged of 18 to 30 years old.

描述

Inclusion Criteria:

Male or female；
Aged of 18 to 30 years old;

Exclusion Criteria:

Presence of pituitary/hypothalamic disorders, polycystic ovarian syndrome， thyroid disorders, hypertension, malignant tumor, cardiac insufficiency，hepatic or renal insufficiency, gastrointestinal disorders and acute infection;
Receiving psychotropic or hormonal medications including hormonal contraception and hormone therapies;
Taking lipid-lowering agents or hypoglycemic agents and other drugs that known to influence cardiovascular health;
Pregnancy or lactation women;
Obviously poor compliance.

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

观测模型：队列
时间观点：其他

团体/队列数

队列和干预

团体/队列
male, non-obese male with BMI<28
male, obese male with BMI≥28
female, non-obese female with BMI<28
female, obese female with BMI≥28

研究衡量的是什么？

主要结果指标

结果测量	大体时间
circadian rhythms of serum lipid levels （the change of serum lipid levels within 24 hours）大体时间：Measured at baseline, and every 10 years during the 40-year follow-up period	Measured at baseline, and every 10 years during the 40-year follow-up period

次要结果测量

结果测量	大体时间
circadian rhythms of gonadal hormone and gonadotropin（the change of gonadal hormone and gonadotropin within 24 hours）大体时间：Measured at baseline, and every 10 years during the 40-year follow-up period	Measured at baseline, and every 10 years during the 40-year follow-up period
circadian rhythms of serum total bile acids（the change of serum total bile acids within 24 hours）大体时间：Measured at baseline, and every 10 years during the 40-year follow-up period	Measured at baseline, and every 10 years during the 40-year follow-up period
change in urine metabolite 大体时间：Measured at baseline, and every 10 years during the 40-year follow-up period	Measured at baseline, and every 10 years during the 40-year follow-up period
change in intestinal flora 大体时间：Measured at baseline, and every 10 years during the 40-year follow-up period	Measured at baseline, and every 10 years during the 40-year follow-up period
change in sperm quality 大体时间：Measured at baseline, and every 10 years during the 40-year follow-up period	Measured at baseline, and every 10 years during the 40-year follow-up period

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Shandong Provincial Hospital

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始

2011年5月1日

初级完成 (预期的)

2050年5月1日

研究完成 (预期的)

2050年5月1日

研究注册日期

首次提交

2018年4月3日

首先提交符合 QC 标准的

2018年9月11日

首次发布 (实际的)

2018年9月13日

研究记录更新

最后更新发布 (实际的)

2022年5月11日

上次提交的符合 QC 标准的更新

2022年5月10日

最后验证

2021年11月1日