The Biological Rhythm of Human Metabolite

Association Between Serum Metabolism Markers and Biological Rhythm

Sponsors

Lead Sponsor: Shandong Provincial Hospital

Source Shandong Provincial Hospital
Brief Summary

The circadian regulation in mammals have been known for a long time. A special group of clock genes, organized in feedback loops, are responsible for the circadian regulation in both the SCN and peripheral organs. The central clock is mainly entrained by the light-dark cycle, while the peripheral ones in organs such as liver and intestine, are more influenced by the feeding-fasting cycles. The coordination of central and peripheral clocks is thought to be essential in the maintenance of physiological homeostasis.This study aim to investigate the association between biological rhythm and metabolism.

Overall Status Active, not recruiting
Start Date May 1, 2011
Completion Date May 1, 2050
Primary Completion Date May 1, 2050
Study Type Observational
Primary Outcome
Measure Time Frame
circadian rhythms of serum lipid levels (the change of serum lipid levels within 24 hours) Measured at baseline, and every 10 years during the 40-year follow-up period
Secondary Outcome
Measure Time Frame
circadian rhythms of gonadal hormone and gonadotropin(the change of gonadal hormone and gonadotropin within 24 hours) Measured at baseline, and every 10 years during the 40-year follow-up period
circadian rhythms of serum total bile acids(the change of serum total bile acids within 24 hours) Measured at baseline, and every 10 years during the 40-year follow-up period
change in urine metabolite Measured at baseline, and every 10 years during the 40-year follow-up period
change in intestinal flora Measured at baseline, and every 10 years during the 40-year follow-up period
change in sperm quality Measured at baseline, and every 10 years during the 40-year follow-up period
Enrollment 200
Condition
Eligibility

Sampling Method: Probability Sample

Criteria:

Inclusion Criteria:

- Male or female;

- Aged of 18 to 30 years old;

Exclusion Criteria:

- Presence of pituitary/hypothalamic disorders, polycystic ovarian syndrome, thyroid disorders, hypertension, malignant tumor, cardiac insufficiency,hepatic or renal insufficiency, gastrointestinal disorders and acute infection;

- Receiving psychotropic or hormonal medications including hormonal contraception and hormone therapies;

- Taking lipid-lowering agents or hypoglycemic agents and other drugs that known to influence cardiovascular health;

- Pregnancy or lactation women;

- Obviously poor compliance.

Gender: All

Minimum Age: 18 Years

Maximum Age: 30 Years

Healthy Volunteers: Accepts Healthy Volunteers

Overall Official
Last Name Role Affiliation
Jiajun Zhao Study Chair Shandong Provincial Hospital
Location
Facility: Shandong Provincial Hospital
Location Countries

China

Verification Date

July 2019

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Shandong Provincial Hospital

Investigator Full Name: Jia-jun Zhao

Investigator Title: Professor

Keywords
Has Expanded Access No
Condition Browse
Arm Group

Label: male, non-obese

Description: male with BMI<28

Label: male, obese

Description: male with BMI≥28

Label: female, non-obese

Description: female with BMI<28

Label: female, obese

Description: female with BMI≥28

Study Design Info

Observational Model: Cohort

Time Perspective: Other

Source: ClinicalTrials.gov