Sleep Disordered Breathing in Acute Congestive Heart Failure
Impact of Sleep Disordered Breathing on Cardiac Injury in Acutely Decompensated Congestive Heart Failure
研究概览
地位
详细说明
Consecutive patients admitted to the hospital with acutely decompensated heart failure will be identified for potential enrollment in this study. Enrolled patients will first be asked to complete questionnaires to assess their symptoms and risk of having sleep apnea.
Relevant information will be obtained from the electronic medical record (age, gender, body mass index, co-morbidities, medications, prior echocardiography results). Subjects will then undergo a "type III" portable monitoring sleep study on the first or second night of their hospital admission, which measures respiratory effort, nasal airflow, oxyhemoglobin saturation, and heart rate. Blood samples will be collected on the evening before (08:00 PM +/- 2 hours), and the morning after (06:00 AM +/-2 hours) sleep apnea testing. If not otherwise obtained clinically, echocardiography will be obtained within 48 hours of admission. After a period of medical management for acutely decompensated heart failure, subjects will then have a second portable sleep apnea study (with associated pre and post-sleep blood draws) on the evening prior to discharge (approximately hospital day 5 or 6). Later, clinical outcomes such as incidence of renal dysfunction, hospital length of stay etc. will be collected from the electronic medical record. Blood samples will be processed, stored, and subsequently analyzed for high-sensitivity cardiac troponin T and I.
研究类型
注册 (实际的)
联系人和位置
学习地点
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California
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San Diego、California、美国、92093-0990
- Altman Clinical and Translational Research Institute
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San Diego、California、美国、92121
- University of California San Diego
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Patients age 18-80 years admitted to University of California San Diego La Jolla campus (Sulpizio Cardiovascular Center, Jacobs Medical Center, and Thornton Hospital) with acute decompensated heart failure will be identified in the emergency department, or upon admission to the cardiology or inpatient general medical services.
Exclusion Criteria:
- Known diagnosis of sleep disordered breathing and on treatment while hospitalized.
- Suspected acute coronary syndrome as determined by the primary clinical team.
- Intensive care unit level care.
- Requiring advanced heart failure therapy such as inotrope infusion, mechanical circulatory support etc.
- Intolerance of study procedures.
- Clinical attending physician refusal
学习计划
研究是如何设计的？
设计细节
- 观测模型：队列
- 时间观点：预期
队列和干预
团体/队列 |
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Heart Failure With Sleep Disordered Breathing
AHI3% >/= 5 events per hour of sleep.
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Heart Failure without Sleep Disordered Breathing
AHI3% < 5 events per hour of sleep.
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Overnight Troponin Change Admission
大体时间：10 hours
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Overnight change in serum troponin concentration PRE vs POST sleep
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10 hours
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Overnight Troponin Change Discharge
大体时间：10 hours
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Overnight change in serum troponin concentration PRE vs POST sleep
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10 hours
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合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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