SARS-CoV-2 (COVID-19) Longitudinal Study: Understanding Susceptibility, Transmission and Disease Severity (Legacy Study)
SARS-CoV-2 Longitudinal Study: Understanding Susceptibility, Transmission and Disease Severity
The study aims to investigate SARS-CoV-2 susceptibility, transmission and disease severity in healthcare workers and patients.
Residual specimens from an existing collection of samples in viral inactivating buffer and derivatives and serum from the Crick COVID-19 Consortium Testing centre (Cohort A1) and additional biological material collected prospectively (Cohorts A2 and B) will be used for research into SARS-CoV-2 transmission, evolution and immune control. This testing centre is a partnership between UCLH and The Francis Crick Institute to provide COVID 19 RT PCR testing for healthcare workers (HCWs) and patients in London Hospitals and care homes. A third group (Cohort C) of the study will allow for collaborative work with other REC approved research studies that have used the Crick COVID-19 Consortium Testing centre and will involve the use of study samples already collected from each study to be analysed under the SARS-CoV-2 Longitudinal Study end points
研究概览
地位
条件
研究类型
注册 (预期的)
联系人和位置
学习联系方式
- 姓名：Charles Swanton
- 电话号码：020 3796 0000
- 邮箱：crick-legacy@crick.ac.uk
学习地点
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London、英国
- 招聘中
- UCLH
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接触：
- B Williams
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London、英国
- 招聘中
- Ealing and Northwick Park hospital
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接触：
- S. Quaid
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首席研究员：
- P. Papineni
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London、英国
- 招聘中
- The Francis Crick Institute
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接触：
- C Swanton
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Individuals who have previously provided nasal throat swab samples for SARS-CoV-2 testing at the Crick COVID 19 Consortium Testing centre.
- ≥18 years of age
- To enrol in the SARS-CoV-2 positive cohort of the study, the participant should have a positive RT qPCR result
- Employees based at the participating sites including who had their serology and/or swab tested (for recruitment to Cohort B)
- Participants enrolled in other studies who had their samples processed by using the Crick COVID 19 Consortium Testing centre (for recruitment to Cohort C).
- Written informed consent (except Cohort A1)
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
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Cohort A1
Healthcare workers and patients that have previously undertaken a swab or serology test to detect for the presence of SARS-CoV-2.
Without the need to seek retrospective consent for the SARS CoV 2 Longitudinal Study, residual samples and derivatives from the Crick COVID -9 Consortium Testing centre and data will be used for the study
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Cohort A2
3,000 SARS-CoV-2 positive and 3,000 SARS-CoV-2 negative participants (randomly selected) from cohort A1 will be prospectively consented to the study.
In addition, vaccine status will also be used to stratify the participants and recruit to the study.
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Cohort B
Employees at participating centres including but not limited to UCLH and The Francis Crick Institute who have their serology tested and/or are swabbed for viral (SARS-CoV-2 and seasonal viruses) detection as well as participants who are vaccinated will be prospectively consented to the study.
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Cohort C
Individuals recruited to other REC approved research studies where their samples are processed by the Crick COVID 19 Consortium Testing centre will also be consented in their existing study to allow the use of leftover study samples already collected and to be collected, for use in this longitudinal study.
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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SARS-CoV-2 susceptibility in healthcare workers and patients
大体时间：24 months
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To investigate SARS-CoV-2 susceptibility by examining the number of positive SARS-CoV-2 result per participant
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24 months
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SARS-CoV-2 transmission in healthcare workers and patients
大体时间：24 months
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To investigate SARS-CoV-2 transmission by analysis of samples sequencing data from each study centre and across study centres
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24 months
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SARS-CoV-2 severity in healthcare workers and patients
大体时间：24 months
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To investigate SARS-CoV-2 severity by review of symptom severity
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24 months
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SARS-CoV-2 severity in healthcare workers and patients
大体时间：24 months
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To investigate SARS-CoV-2 severity by review of any hospital admissions
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24 months
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合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.