Prognostic Factors for Treatment Responses in Patients With Active Lupus Nephritis at Sohag University Hospital
研究概览
地位
干预/治疗
详细说明
This study will be prospectively analyzing the clinical data of LN patients who received standard immunosuppressive therapy and were regularly followed up at our center for more than six months. These patients will not change treatment regimen during the six months.
As remission is an independent predictor of good long term prognosis in lupus nephritis. We aim to examine the predictors of sustained complete renal remission in patients with lupus nephritis at Sohag University Hospital and to analyze data of lupus nephritis patients to find parameters that can predict remission and improve outcome of our cases
研究类型
注册 (预期的)
联系人和位置
学习地点
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Sohag、埃及、088
- Sohag University
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
o Patients diagnosed with LN at Sohag University Hospital
- Patients in regular follow-up for more than six months after immunosuppressive therapy
- Baseline urinary protein/creatinine ratio (UPCR) more than 1 g/g
- Baseline C3 less than 55 mg/ dl
- No change in immunosuppressive therapy within six months
Exclusion Criteria:
o Patients with incomplete pathological data and the number of glomeruli being <10 per biopsy specimen
- Age <14 years old End-stage renal disease (ESRD) status on admission (sustained estimated glomerular filtration rate (eGFR) <15 ml/min per 1.73m2)
- Patients with advanced comorbid conditions like advanced liver cirrhosis or heart failure or malignancy
学习计划
研究是如何设计的？
设计细节
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
complete renal response
大体时间：6 months
|
Alb _35 g/l, UPCR<0.3
g/g, a normal range of sCr or at a level increasing no more than 15% from baseline and without lupus flares.
|
6 months
|
合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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