The Effect of Minimal Flow Sevoflurane Anesthesia
The Effect of Minimal Flow Sevoflurane Anesthesia on Blood Gas Analysis and Hemodynamic Parameters in Laparoscopic Cholecystectomies, a Randomised Controlled Trial.
研究概览
详细说明
Introduction: Low-flow anesthesia techniques have regained popularity in recent years with the development of low solubility volatile agents such as sevoflurane and desflurane, and modern anesthesia devices. Reducing the flow of fresh gas as much as possible will reduce the amount of volatile agent used, thus preventing air pollution, providing lower costs, and also preserving heat and moisture in the respiratory tract by using rebreathing systems. Laparoscopic surgery is superior to open surgical techniques due to its minimally invasive nature, less postoperative pain, less incidence of wound infections, shortening the hospitalization, and allowing patients to return to their normal lives sooner after the operation.
Our aim is to investigate the effect of minimal flow anesthesia with sevoflurane on hemodynamics and arterial blood gas parameters in laparoscopic cholecystectomy operations.
Material and Method: Seventy patients with ASA (American Society of Anesthesiologists) class I-II between the ages of 18-65 undergoing elective laparoscopic cholecystectomy were included in the study. After the patients were randomly selected by computer, they were divided into two equal groups as Group M (minimal flow anesthesia group) with fresh gas flow 0,5 L.min-1 and Group C (high flow anesthesia/ control group) with fresh gas flow 4 L.min-1. In both groups. Demographic data, duration of anesthesia, operation times, recovery times, hemodynamic parameters and arterial blood gas parameters of all patients were recorded. The patient data collected in both groups were compared statistically.
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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Istanbul
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Şi̇şli̇、Istanbul、火鸡、34736
- Nebia Peker
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- ASA (American Society of Anesthesiologists) class I-II
- The operation time between 60-180 minutes
Exclusion Criteria:
- Severe cardiac disease
- COPD (Chronic Obstructive Pulmonary Disease)
- Severe liver and kidney disease,
- Diabetes mellitus
- Morbid obesity
- Alcohol and/or drug addiction
- Risk or history of malignant hyperthermia
- Pregnancy and lactation
- Emergency cases
- Operation time less than 60 minutes and longer than 180 minutes
学习计划
研究是如何设计的?
设计细节
- 主要用途:治疗
- 分配:随机化
- 介入模型:并行分配
- 屏蔽:无(打开标签)
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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有源比较器:Group M
Group M is minimal flow anesthesia group with fresh gas flow 0,5 L.min-1.
Thirty five patients with ASA class I-II and between the ages of 18-65 undergoing elective laparoscopic cholecystectomy will be included.
These patients were planned to be administered sevoflurane anesthesia with 0,5 L.min-1 flow under general anesthesia.
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The sevoflurane dose differed in both groups in relation to the fresh gas flow.
Since the fresh gas flow is less in group M, the concentration of sevoflurane consumed by the patient at the end of the case will be less.
其他名称:
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有源比较器:Group H
Group H is high flow anesthesia group with fresh gas flow 4 L.min-1.
Thirty five patients with ASA class I-II and between the ages of 18-65 undergoing elective laparoscopic cholecystectomy will be included.
These patients were planned to be administered sevoflurane anesthesia with 4 L.min-1 flow under general anesthesia.
|
The sevoflurane dose differed in both groups in relation to the fresh gas flow.
Since the fresh gas flow is less in group M, the concentration of sevoflurane consumed by the patient at the end of the case will be less.
其他名称:
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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CHANGE IN P/F
大体时间:from the beginning to the end of anesthesia
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PaO2/FiO2 ratio is the ratio of arterial oxygen partial pressure (PaO2 in mmHg) to fractional inspired oxygen (FiO2 expressed as a fraction, not a percentage).
P/F ratio is a widely used clinical indicator of hypoxaemia
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from the beginning to the end of anesthesia
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CHANGE IN PaCO2
大体时间:from the beginning to the end of anesthesia
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The partial pressure of carbon dioxide is the measure of carbon dioxide within arterial blood.
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from the beginning to the end of anesthesia
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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volatile agent consumption amount
大体时间:from the beginning to the end of anesthesia
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the total amount of volatile agent (sevoflurane) consumed at the end of the surgery
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from the beginning to the end of anesthesia
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其他结果措施
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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CHANGE IN HR
大体时间:from the beginning to the end of anesthesia
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Heart rate per minute
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from the beginning to the end of anesthesia
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CHANGE IN MAP
大体时间:from the beginning to the end of anesthesia
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Mean arterial pressure
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from the beginning to the end of anesthesia
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合作者和调查者
调查人员
- 学习椅:Nurcan Coşkun、Şişli Hamidiye Etfal Training and Research Hospital
- 学习椅:Serkan İslamoğlu、Şişli Hamidiye Etfal Training and Research Hospital
出版物和有用的链接
一般刊物
- Doger C, Kahveci K, Ornek D, But A, Aksoy M, Gokcinar D, Katar D. Effects of Low-Flow Sevoflurane Anesthesia on Pulmonary Functions in Patients Undergoing Laparoscopic Abdominal Surgery. Biomed Res Int. 2016;2016:3068467. doi: 10.1155/2016/3068467. Epub 2016 Jun 20.
- Park SY, Chung CJ, Jang JH, Bae JY, Choi SR. The safety and efficacy of minimal-flow desflurane anesthesia during prolonged laparoscopic surgery. Korean J Anesthesiol. 2012 Dec;63(6):498-503. doi: 10.4097/kjae.2012.63.6.498. Epub 2012 Dec 14.
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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