Loss of Independence - a Rapid Alternative to Frailty Screening in a Swedish ED Setting
Loss of Independence (LOI) - a Rapid Alternative to Frailty Screening in a Swedish Emergency Department Setting
This prospective observational study will investigate the correlation of a surrogate marker of frailty in relation to serious outcomes. Serious outcomes are defined as: mortality within 30 days, admission to hospital, length of stay in the Emergency Department (ED), in-hospital Length of Stay and revisits to the ED.
The exposure, frailty, will be assessed according to Loss of Independence (LOI) a possible low-cost quick tool to identify frailty in patients. The study population will be ED patients, >65 years of age in a Swedish regional health care system (Region Östergötland, Sweden), comprising three EDs in Linköping, Norrköping and Motala. The outcomes will be compared according to the degree of frailty and censored over 7, 30 and 90 days.
研究概览
详细说明
Frailty is a common clinical syndrome in older adults that carries an increased risk for poor health outcomes including falls, incident disability, hospitalization and mortality.
The Loss of Independence (LOI) defined as inability to rise from a chair with or without existing aids, is a possible low cost surrogate marker to measure frailty. Several studies on triage scores for predicting mortality and need of hospital admission have identified LOI as one of the most important variables. LOI was prognostic in ED populations regarding mortality within 1-30 days in Denmark, Ireland and Tanzania. Data from the American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) Geriatric Surgery Pilot Project showed that LOI was associated with higher rates of readmission and death after discharge in geriatric patients undergoing surgical procedures6.
The aim of this study will be to investigate if the frailty, as assessed with LOI, is associated with increased 30-day mortality in a Swedish ED context. Secondary outcomes include 7- and 90-day mortality, ED-length of stay, hospital admission, in-hospital length of stay, subsequent falls and medication changes. Additionally, we collect data on morbidity and comorbidities to assess the association with the level of frailty. Since this is a multicentre study, possible geographic differences will be studied as well. Based on the results of this study, possible interventions could be identified to improve the care of the frail geriatric patients presenting at the ED.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Östergötland
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Linköping、Östergötland、瑞典、58185
- University Hospital Linköping
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Motala、Östergötland、瑞典
- Medicinska Specialist Kliniken i Motala
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Norrköping、Östergötland、瑞典
- Vrinnevisjukhuset i Norrköping
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- ≥ 65 years
- able to answer questions to estimate frailty
- or have a proxy to answer questions
Exclusion Criteria:
- <65 years
- unable to answer questions to estimate frailty
学习计划
研究是如何设计的?
设计细节
研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Mortality in 30 Days
大体时间:All cause mortality up to 30 days from index visit
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Investigate level of mortality in cohort at 30 days
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All cause mortality up to 30 days from index visit
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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7 天和 90 天的死亡率
大体时间:首次就诊后 90 天内的全因死亡率
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调查队列中第 7 天和第 90 天的死亡率水平
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首次就诊后 90 天内的全因死亡率
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入院
大体时间:首次就诊入院,90 天截尾
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调查队列中全因招生的水平
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首次就诊入院,90 天截尾
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住院时间
大体时间:在 ED 的停留时间,审查为 4 天
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调查在 ED 的住院时间
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在 ED 的停留时间,审查为 4 天
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In-hospital length of stay
大体时间:In-hospital length of stay from index visit, censored at 90 days
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Investigate in-hospital length of stay
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In-hospital length of stay from index visit, censored at 90 days
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Revisits to the ED
大体时间:Number of newly registered visits to the ED after index visit, censored at 90 days
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Number of newly registered visits to the ED after index visit
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Number of newly registered visits to the ED after index visit, censored at 90 days
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Fall prevalence after index visit
大体时间:Falls that resulted in further health care contacts after index visit, censored at 90 days
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Falls that resulted in further health care contacts
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Falls that resulted in further health care contacts after index visit, censored at 90 days
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Alterations in medication during the visit
大体时间:Alterations in medication during the ED visit and during the follow-up period, censored at 90 days
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Alterations in medication during the ED visit and during the follow-up period(based on codes for Anatomical, Therapeutic, Chemical classification (ATC-code)
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Alterations in medication during the ED visit and during the follow-up period, censored at 90 days
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合作者和调查者
出版物和有用的链接
一般刊物
- Kellett J, Deane B. The Simple Clinical Score predicts mortality for 30 days after admission to an acute medical unit. QJM. 2006 Nov;99(11):771-81. doi: 10.1093/qjmed/hcl112. Epub 2006 Oct 17.
- Kellett J, Deane B, Gleeson M. Derivation and validation of a score based on Hypotension, Oxygen saturation, low Temperature, ECG changes and Loss of independence (HOTEL) that predicts early mortality between 15 min and 24 h after admission to an acute medical unit. Resuscitation. 2008 Jul;78(1):52-8. doi: 10.1016/j.resuscitation.2008.02.011. Epub 2008 Apr 10.
- Brabrand M, Folkestad L, Clausen NG, Knudsen T, Hallas J. Risk scoring systems for adults admitted to the emergency department: a systematic review. Scand J Trauma Resusc Emerg Med. 2010 Feb 11;18:8. doi: 10.1186/1757-7241-18-8.
- Brabrand M, Lassen AT, Knudsen T, Hallas J. Seven-day mortality can be predicted in medical patients by blood pressure, age, respiratory rate, loss of independence, and peripheral oxygen saturation (the PARIS score): a prospective cohort study with external validation. PLoS One. 2015 Apr 13;10(4):e0122480. doi: 10.1371/journal.pone.0122480. eCollection 2015.
- Rylance J, Baker T, Mushi E, Mashaga D. Use of an early warning score and ability to walk predicts mortality in medical patients admitted to hospitals in Tanzania. Trans R Soc Trop Med Hyg. 2009 Aug;103(8):790-4. doi: 10.1016/j.trstmh.2009.05.004. Epub 2009 Jun 21.
- Berian JR, Mohanty S, Ko CY, Rosenthal RA, Robinson TN. Association of Loss of Independence With Readmission and Death After Discharge in Older Patients After Surgical Procedures. JAMA Surg. 2016 Sep 21;151(9):e161689. doi: 10.1001/jamasurg.2016.1689. Epub 2016 Sep 21.
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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