Contribution of a* to Dental Bleaching After Combined Dental Bleaching
Contribution of the a* Parameter to Dental Bleaching After Combined Bleaching: A Prospective Non-randomized Single-arm Interventional Clinical Study
研究概览
详细说明
Tooth whitening is one of the most commonly requested aesthetic dental treatments, requiring objective and reproducible methods to quantify color changes. The CIELab color system (L*, a*, b*) and the Whiteness Index for Dentistry (WID) are widely used for this purpose.
While increases in L* and decreases in b* are recognized as the main contributors to dental whitening, the role of the a* parameter remains unclear. Variations in a*, including the presence of negative values or changes in sign during treatment, have been insufficiently studied.
A prospective, non-randomized, single-arm interventional clinical study with a before-after design will be conducted to evaluate changes in L*, a*, b*, and WID following a combined dental bleaching protocol consisting of an in-office phase with hydrogen peroxide and an at-home phase with carbamide peroxide.
Spectrophotometric measurements will be performed at baseline, after the in-office phase, and after completion of the at-home phase. The study will also analyze the relationship between changes in CIELab parameters and WID.
The study will be conducted in accordance with ethical standards and will be approved by the corresponding institutional review board. All participants will provide written informed consent prior to inclusion.
研究类型
注册 (估计的)
阶段
- 不适用
联系人和位置
学习联系方式
- 姓名：José Amengual-Lorenzo, PhD
- 电话号码：+34616941167
- 邮箱：jose.amengual@uv.es
研究联系人备份
- 姓名：Rubén Agustín Panadero, MSc; Phd
- 电话号码：+34653098901
- 邮箱：ruben.agustin@uv.es
学习地点
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Valencia
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Valencia、Valencia、西班牙、46010
- University of Valencia
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接触：
- José Amengual Lorenzo, Phd
- 电话号码：+34616941167
- 邮箱：jose.amengual@uv.es
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接触：
- Rubén Agustín-Panader, MsC; PhD
- 电话号码：+34653098901
- 邮箱：ruben.agustin@uv.es
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首席研究员：
- José Amengual-Lorenzo, PhD
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参与标准
资格标准
适合学习的年龄
- 成人
- 年长者
接受健康志愿者
描述
Inclusion Criteria
- Age 18 to 65 years
- Good oral health
- Presence of natural anterior teeth (incisors, canines, premolars)
- Anterior teeth without restorations
- Indication for tooth bleaching treatment
- Ability to comply with study procedures and visits
Exclusion Criteria
- Smoking
- Previous tooth bleaching treatment
- Pregnancy
- Breastfeeding
- Restorations in anterior teeth
- Presence of diseases affecting tooth color
- Conditions that may interfere with study outcomes
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：不适用
- 介入模型：单组作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：Combined Dental Bleaching
Participants will undergo a combined dental bleaching treatment consisting of an in-office phase followed by an at-home phase using custom trays.
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The intervention consists of an in-office bleaching phase with two 20-minute applications of 40% hydrogen peroxide, followed by an at-home bleaching phase using 16% carbamide peroxide applied with custom trays for 90 minutes daily.
Treatment will continue until color stabilization is achieved, defined as a change in WID of less than 2.6 units between two consecutive weekly measurements.
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Change in Whiteness Index for Dentistry (WID)
大体时间：From baseline to end of treatment (up to 12 weeks).
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Change in WID values calculated from CIELab parameters (L*, a*, b*) between baseline and the end of treatment (up to 12 weeks).
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From baseline to end of treatment (up to 12 weeks).
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Change in L* parameter
大体时间：Baseline to end of treatment (up to 12 weeks).
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Difference in L* values between baseline and the end of treatment (up to 12 weeks) measured using spectrophotometry.
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Baseline to end of treatment (up to 12 weeks).
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Change in a* parameter
大体时间：Baseline to end of treatment (up to 12 weeks).
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Difference in a* values between baseline and the end of treatment (up to 12 weeks), including assessment of sign changes.
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Baseline to end of treatment (up to 12 weeks).
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Change in b* parameter
大体时间：Baseline to end of treatment (up to 12 weeks)
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Difference in b* values between baseline and the end of treatment (up to 12 weeks), measured using spectrophotometry.
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Baseline to end of treatment (up to 12 weeks)
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Correlation between WID and CIELab parameters
大体时间：At end of treatment (up to 12 weeks).
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Assessment of the relationship between changes in WID and changes in L*, a*, and b*.
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At end of treatment (up to 12 weeks).
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合作者和调查者
调查人员
- 首席研究员：José Amengual-Lorenzo、University of Valencia
出版物和有用的链接
研究记录日期
研究主要日期
学习开始 (估计的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- Bleaching_aStar_WID_2026
- Application Reference 2026-ODO (其他标识符：Ethics Committee University of Valencia)
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IPD 计划说明
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