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Effects Of A Rehabilitation Protocol On Muscle Strength, Muscle Fatigue And Postural Control In Post-Dengue And Chikungunya Patients

2026年5月20日更新者：Maria Cláudia Valente Almeida、Universidade do Estado do Pará

Effects Of A Rehabilitation Protocol On Muscle Strength, Muscle Fatigue And Postural Control In Post-Dengue And Chikungunya Patients: Non-Randomized Clinical Trial

Introduction: Dengue and Chikungunya arboviral diseases are considered major public health challenges in tropical regions due to high infection rates and the occurrence of musculoskeletal sequelae that impair strength, balance, and functionality. After the acute phase, symptoms such as fatigue, joint pain, muscle weakness, and postural instability are common, reducing quality of life and hindering social and occupational reintegration.Objective: To analyze the effects of a rehabilitation protocol on muscle fatigue, muscle strength, and postural control in post-Dengue and Chikungunya patients.Methods: This is a non-randomized clinical trial conducted at the Integrated Laboratory for Research and Care in Infectious and Sequelae Diseases (LabDIS/UEPA). Individuals of both sexes, aged over 18 years, with a confirmed diagnosis of Dengue and/or Chikungunya within the last five years will be included. Data collection will include a clinical interview, surface electromyography of the flexor carpi radialis, tibialis anterior, lateral and medial gastrocnemius muscles, hydraulic and electronic dynamometry, manovacuometry, and baropodometry. The rehabilitation protocol will consist of twenty supervised sessions of aerobic, anaerobic, and respiratory exercises.Expected Results: Improvements in muscle strength, muscle fatigue, and postural control are expected following the intervention.Conclusion: The findings may support physiotherapeutic strategies aimed at improving strength, fatigue, and balance, expanding knowledge on the neuromuscular and respiratory consequences of arboviral diseases, and contributing to the development of evidence-based rehabilitation protocols, with potential positive impacts on healthcare delivery and public health policies.

研究概览

地位

尚未招聘

条件

干预/治疗

其他：Exercise

研究类型

介入性

注册 (估计的)

阶段

不适用

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习联系方式

姓名：Maria Cláudia V Almeida, Principal Investigator
电话号码：+55 (91) 99102-9191
邮箱：maria.cv.almeid@aluno.uepa.br

学习地点

巴西
- Pará
  - Belém、Pará、巴西、66.087-670
    - Universidade do Estado do Pará
    - 接触：
      
      Márcio C de souza santos, Coordinator
      
      电话号码：+55 (91) 98134-9895
      
      邮箱：marcio.clementino@gmail.com

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

成人
年长者

接受健康志愿者

不

描述

Inclusion Criteria:

Adults aged 18 years or older
Individuals of both sexes
Residents of the 1st, 4th, or 11th Health Regions of the state of Pará
Confirmed diagnosis of Dengue (DENV) and/or Chikungunya (CHIKV) infection by serological testing (ELISA or IgG/IgM)
Diagnosis confirmed within the last 5 years
Ability to provide written informed consent

Exclusion Criteria:

Hemodynamic instability
Musculoskeletal instability, including fractures or acute muscle injuries
Cognitive deficits impairing the understanding of commands or study procedures
History of balance disorders prior to Dengue or Chikungunya infection
Obesity
Blindness or low vision
Hearing impairment

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

主要用途：治疗
分配：不适用
介入模型：顺序分配
屏蔽：无（打开标签）

手臂数量

武器和干预

参与者组/臂	干预/治疗
实验性的：Intervention Group Post-Dengue And Chikungunya Patients	其他：Exercise The rehabilitation protocol will include 20 sessions, twice weekly. Anaerobic training will involve vertical chest press, lat pulldown, leg extension, and 180° leg press, with a prior 1RM test. Sessions 1-5 and 11-15: 3 sets of 12 reps at 55% 1RM; sessions 6-10 and 16-20: 3 sets of 15 reps at 55% 1RM. Aerobic training will be performed on a treadmill or cycle ergometer, progressing from 41-50% HRR (sessions 1-5), 51-60% (6-10), 61-70% (11-15), and 71-80% (16-20). Respiratory training will use the PowerBreathe® device: sessions 1-10 at 30% MIP with 10 repetitions, and sessions 11-20 at 40% MIP with 10 repetitions.

参与者组/臂

干预/治疗

实验性的：Intervention Group

Post-Dengue And Chikungunya Patients

其他：Exercise

The rehabilitation protocol will include 20 sessions, twice weekly. Anaerobic training will involve vertical chest press, lat pulldown, leg extension, and 180° leg press, with a prior 1RM test. Sessions 1-5 and 11-15: 3 sets of 12 reps at 55% 1RM; sessions 6-10 and 16-20: 3 sets of 15 reps at 55% 1RM. Aerobic training will be performed on a treadmill or cycle ergometer, progressing from 41-50% HRR (sessions 1-5), 51-60% (6-10), 61-70% (11-15), and 71-80% (16-20). Respiratory training will use the PowerBreathe® device: sessions 1-10 at 30% MIP with 10 repetitions, and sessions 11-20 at 40% MIP with 10 repetitions.

研究衡量的是什么？

主要结果指标

结果测量	措施说明	大体时间
Muscle fatigue assessed by surface electromyography 大体时间：Baseline and immediately after completion of the intervention protocol	Surface electromyography (EMG) will be used to evaluate muscle activity and fatigue of the flexor carpi radialis, tibialis anterior, medial gastrocnemius, and lateral gastrocnemius muscles using the New Miotool Wireless® system. Muscle fatigue will be analyzed through Mean Frequency (MNF) slope during sustained isometric contraction	Baseline and immediately after completion of the intervention protocol

次要结果测量

结果测量	措施说明	大体时间
Handgrip strength assessed by hydraulic dynamometry 大体时间：Baseline and immediately after completion of the intervention protocol	Handgrip strength will be measured using a calibrated Crown® hydraulic hand dynamometer following the American Society of Hand Therapists (ASHT) recommendations. Maximal isometric grip strength will be recorded in kilogram-force (kgf).	Baseline and immediately after completion of the intervention protocol
Peripheral muscle strength assessed by electronic dynamometry 大体时间：Baseline and immediately after completion of the intervention protocol	Maximum isometric muscle strength of wrist flexors/extensors and ankle dorsiflexors/plantar flexors will be assessed using the MedEOR Medtech® digital dynamometer. Strength values will be recorded in kilogram-force (kgf).	Baseline and immediately after completion of the intervention protocol
Postural control assessed by baropodometry 大体时间：Baseline and immediately after completion of the intervention protocol	Postural control and plantar pressure distribution will be evaluated using the Footwork Pro AM³ pressure platform. Stabilometric variables will include center of pressure displacement, oscillation area, and postural sway under eyes-open and eyes-closed conditions.	Baseline and immediately after completion of the intervention protocol
Respiratory muscle strength assessed by manovacuometry 大体时间：Baseline and immediately after completion of the intervention protocol	Respiratory muscle strength will be assessed using a digital manovacuometer (MVD300-U). Maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP) will be measured in cmH₂O.	Baseline and immediately after completion of the intervention protocol

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Universidade do Estado do Pará

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (估计的)

2026年7月1日

初级完成 (估计的)

2027年7月1日

研究完成 (估计的)

2027年7月30日

研究注册日期

首次提交

2026年5月7日

首先提交符合 QC 标准的

2026年5月14日

首次发布 (实际的)

2026年5月22日

研究记录更新

最后更新发布 (实际的)

2026年5月26日

上次提交的符合 QC 标准的更新

2026年5月20日

最后验证

2026年5月1日

Effects Of A Rehabilitation Protocol On Muscle Strength, Muscle Fatigue And Postural Control In Post-Dengue And Chikungunya Patients