Physical Therapy Program and Treatment Expectations in Knee Osteoarthritis
2026年6月8日 更新者:Levent Karataş、Gazi University
Evaluating The Predictive Effect of Treatment Expectations on Response to A Physical Therapy Program in Patients With Knee Osteoarthritis
To our knowledge, no studies have been conducted in the literature investigating the relationship between the success of physical therapy programs applied in knee osteoarthritis and patients' pre-treatment expectations.
The rationale for this study is to demonstrate the possible relationship between treatment expectations and the benefits seen from conventional physical therapy programs in patients with knee osteoarthritis, and to provide clinicians with a different perspective in knee osteoarthritis treatment planning.
研究概览
详细说明
Osteoarthritis, also called degenerative joint disease, primarily occurs in old age, but can also develop after trauma or secondarily to diseases such as rheumatoid arthritis and hemochromatosis.
Osteoarthritis is the most common joint disease worldwide.
The pathophysiology of osteoarthritis is responsible for the failed repair of joint damage caused by stress initiated by any joint or periarticular tissue abnormality.
The most common symptom of osteoarthritis is pain.
Factors associated with an increased risk of knee osteoarthritis include advanced age, family history, overweight or obesity, a history of knee trauma, occupational factors, and varus or valgus alignment.
Long-term complications of osteoarthritis include decreased physical activity, loss of fitness, sleep disturbances, fatigue, and depression.
With the increasing aging population, degenerative joint problems have become a concern for a large part of society.
Exercise is a key component in the treatment of this chronic disease, which restricts functionality and reduces quality of life.
A systematic review of 54 randomized controlled trials involving a total of 5362 participants showed that different types of exercise improved pain, functionality, and quality of life in knee osteoarthritis.
Studies have shown that treatment outcomes are not always similar in patients undergoing similar treatment programs, and that patients' expectations from treatment can also influence results.
A systematic literature review on improvement expectations revealed that in 15 out of 16 studies, positive patient expectations were associated with better health outcomes.
A recent study in the field of physical therapy also showed that in the treatment of chronic low back pain, high patient expectations were associated with the success of the treatment.
Therefore, we planned this study to answer the questions of whether treatment expectations have a predictive effect on the benefits seen from an exercise program in patients with knee osteoarthritis, and whether it is necessary to evaluate the level of expectations when creating a treatment program for patients with knee osteoarthritis.
研究类型
观察性的
注册 (估计的)
84
联系人和位置
本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。
学习联系方式
- 姓名:Burak Tokac
- 电话号码:+905313474837
- 邮箱:buraktokac96@gmail.com
研究联系人备份
- 姓名:Levent Karatas
- 电话号码:+9005055629437
学习地点
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Yenimahalle
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Ankara、Yenimahalle、土耳其(türkiye)、06170
- 招聘中
- Gazi University
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接触:
- Levent Karatas, Doc
- 电话号码:+90 505 562 94 37
- 邮箱:dr.levent.karatas@gmail.com
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参与标准
研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
- 成人
- 年长者
接受健康志愿者
不
取样方法
概率样本
研究人群
Patients aged 50 years and older who present with knee pain and are found to have grade 2 or higher gonarthrosis according to the Kellgren-Lawrence classification on X-ray imaging.
描述
Inclusion Criteria:
- Agreeing to participate in the study
- Being over 50 years of age
- Having a clinically and radiographically confirmed diagnosis of knee osteoarthritis
- Having grade 2-3-4 knee osteoarthritis according to the Kellgren-Lawrence grading system
- Being literate
Exclusion Criteria:
- Previous knee surgery
- Conditions that prevent exercise (such as incurable malignancy, active systemic infection, non-union fracture)
- Presence of accompanying neurological disease affecting the lower extremity
- Severe cognitive impairment (neuropsychiatric disease or condition that will impede cooperation, such as psychosis, dementia)
- History of having received injections or other procedures to the knee joint or physical therapy within the last 6 months
学习计划
本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
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Those with Low Treatment Expectations
Using the Turkish version of the Treatment Expectation Questionnaire (TEX-Q)(English version is provided in the documents section), patients will be divided into two groups: those with low expectations and those with high expectations.
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Patients in both groups will receive 15 sessions of a conventional physical therapy program.
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Those with High Treatment Expectations
Using the Turkish version of the Treatment Expectation Questionnaire (TEX-Q)(English version is provided in the documents section), patients will be divided into two groups: those with low expectations and those with high expectations.
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Patients in both groups will receive 15 sessions of a conventional physical therapy program.
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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The Western Ontario and McMaster Universities Arthritis Index (WOMAC) score
大体时间:From enrollment day to the end of the rehabilitation program at 4 weeks
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WOMAC score evaluation following the last treatment session.
The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) is a widely used, validated questionnaire designed to assess pain, stiffness, and physical function in patients with knee and hip osteoarthritis.
It consists of 24 items divided into three subscales: pain (5 items), stiffness (2 items), and physical function (17 items).
Patients rate their symptoms on a Likert scale, with higher scores indicating worse pain, stiffness, or functional limitations.
The WOMAC is commonly used in clinical research to evaluate the efficacy of various treatments for osteoarthritis.
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From enrollment day to the end of the rehabilitation program at 4 weeks
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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疼痛程度;视觉模拟评分
大体时间:从入学之日到康复计划结束4周
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视觉模拟量表(VAS)是一种用于测量患者疼痛程度的工具。
它由一条直线组成,其端点定义了极端限制,例如“无疼痛”和“可想象的最严重的疼痛”。
患者在线上标记他们认为代表他们对当前状态的看法的点。
这种方法简单、可靠,广泛应用于临床和研究环境中来量化疼痛强度。
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从入学之日到康复计划结束4周
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Timed Up and Go Test (TUG)
大体时间:From enrollment day to the end of the rehabilitation program at 4 weeks
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A rapid, standardized clinical tool used to measure a person's functional mobility, dynamic balance, and fall risk.
It measures the time it takes for a person to get up from a chair, walk 3 meters (10 feet), turn around, walk back, and sit down again.
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From enrollment day to the end of the rehabilitation program at 4 weeks
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Stair Climbing Test (SCT)
大体时间:From enrollment day to the end of the rehabilitation program at 4 weeks
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The stair climbing test assesses lower body strength, functional capacity, and cardiopulmonary fitness by measuring how quickly you can safely climb and descend a flight of stairs.
Versions are available with 3 to 12 steps; this study will use the 12-step version.
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From enrollment day to the end of the rehabilitation program at 4 weeks
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 首席研究员:Levent Karatas、Gazi University
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
一般刊物
- Fransen M, McConnell S, Harmer AR, Van der Esch M, Simic M, Bennell KL. Exercise for osteoarthritis of the knee: a Cochrane systematic review. Br J Sports Med. 2015 Dec;49(24):1554-7. doi: 10.1136/bjsports-2015-095424. Epub 2015 Sep 24.
- Lespasio MJ, Piuzzi NS, Husni ME, Muschler GF, Guarino A, Mont MA. Knee Osteoarthritis: A Primer. Perm J. 2017;21:16-183. doi: 10.7812/TPP/16-183.
- Myers SS, Phillips RS, Davis RB, Cherkin DC, Legedza A, Kaptchuk TJ, Hrbek A, Buring JE, Post D, Connelly MT, Eisenberg DM. Patient expectations as predictors of outcome in patients with acute low back pain. J Gen Intern Med. 2008 Feb;23(2):148-53. doi: 10.1007/s11606-007-0460-5. Epub 2007 Dec 8.
- Jang S, Lee K, Ju JH. Recent Updates of Diagnosis, Pathophysiology, and Treatment on Osteoarthritis of the Knee. Int J Mol Sci. 2021 Mar 5;22(5):2619. doi: 10.3390/ijms22052619.
- Mondloch MV, Cole DC, Frank JW. Does how you do depend on how you think you'll do? A systematic review of the evidence for a relation between patients' recovery expectations and health outcomes. CMAJ. 2001 Jul 24;165(2):174-9.
- Levenig CG, Hasenbring MI, Gunnewig L, Titze C, Elsenbruch S, Schulte TL. Treatment Expectations-You Get What You Expect-and Depression Plays a Role. J Pain. 2024 Sep;25(9):104582. doi: 10.1016/j.jpain.2024.104582. Epub 2024 May 29.
- Robinson ME, Brown JL, George SZ, Edwards PS, Atchison JW, Hirsh AT, Waxenberg LB, Wittmer V, Fillingim RB. Multidimensional success criteria and expectations for treatment of chronic pain: the patient perspective. Pain Med. 2005 Sep-Oct;6(5):336-45. doi: 10.1111/j.1526-4637.2005.00059.x.
- Abdel-Aziz MA, Ahmed HMS, El-Nekeety AA, Abdel-Wahhab MA. Osteoarthritis complications and the recent therapeutic approaches. Inflammopharmacology. 2021 Dec;29(6):1653-1667. doi: 10.1007/s10787-021-00888-7. Epub 2021 Nov 9.
- Hsu H, Siwiec RM. Knee Osteoarthritis. 2023 Jun 26. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK507884/
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2026年1月1日
初级完成 (估计的)
2027年9月1日
研究完成 (估计的)
2027年9月15日
研究注册日期
首次提交
2026年5月24日
首先提交符合 QC 标准的
2026年5月24日
首次发布 (实际的)
2026年6月1日
研究记录更新
最后更新发布 (实际的)
2026年6月10日
上次提交的符合 QC 标准的更新
2026年6月8日
最后验证
2026年6月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.